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CAS No. :	870483-87-7
Formula :	C₂₀H₂₂N₄O₃
M.W :	366.41
SMILES Code :	NC1=NC=C(CC2=CC=C(OCC3=CC=C(OC)C=C3)C(OC)=C2)C(N)=N1
MDL No. :	MFCD12024701
InChI Key :	MYQAUKPBNJWPIE-UHFFFAOYSA-N
Pubchem ID :	11617559

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Human osteoclasts	1 μM	3 days	Inhibited bone degradation and actin-ring formation	PMC1276040
Freshly isolated human monocytes	0.47 μM	5 days	Completely inhibited CSF-1-induced growth	PMC1276040
Mouse myeloid NS0 cells	13.5 μM		No significant effect on CSF-1-independent cell growth	PMC1276040
Mouse myeloid M-NFS-60 cells	0.33 μM		Completely inhibited CSF-1-induced cell growth	PMC1276040
Human islet cells	10 mg/ml		Assess toxicity of GW2580 on human islet cells	PMC7184801
Mouse satellite glial cells (SGCs)	20 mg/mL	1, 3, 7 days	To evaluate the effect of PLGA and PLGAM microparticles on the proliferation of SGCs, results showed no significant effect on cell proliferation.	PMC10066835
Human adipose mesenchymal stem cells (ADMSCs)	20 mg/mL	1, 3, 7 days	To evaluate the effect of PLGA and PLGAM microparticles on the proliferation of ADMSCs, results showed no significant effect on cell proliferation.	PMC10066835
Mouse bone marrow mesenchymal stem cells (mBMSCs)	10 μM	24 and 72 hours	To study the effect of GW2580 on mBMSCs proliferation, adhesion, and osteogenic differentiation. Results showed that GW2580 did not affect mBMSCs function at the later stage of release and promoted osteogenesis.	PMC9079115
Mouse bone marrow-derived monocytes (BMMs)	10 μM	24 and 72 hours	To study the inhibitory effect of GW2580 on BMMs proliferation and osteoclast differentiation. Results showed that GW2580 significantly inhibited BMMs proliferation and osteoclast differentiation.	PMC9079115
Human peripheral blood mononuclear cells	470 nM or 4.7 μM	24 hours	To investigate the effect of GW2580 on M-CSF or IL-34-induced CD163 and CD16 expression, results showed GW2580 could inhibit the expression of these markers	PMC4381451
Rhesus macaque peripheral blood mononuclear cells	470 nM or 4.7 μM	24 hours	To investigate the effect of GW2580 on M-CSF or IL-34-induced CD163 and CD16 expression, results showed GW2580 could inhibit the expression of these markers	PMC4381451
RAW264.7 cells	10 μM	4 hours	To study the inhibitory effect of GW2580 on CSF-1R and NF-κB signaling pathways. Results showed that released GW2580 effectively inhibited phosphorylation of CSF-1R and significantly attenuated phosphorylation of AKT and NF-κB signaling pathways.	PMC9079115
RAW 264.7 cells	10–1000 nM	48 hours	GW2580 reduced MCSF-stimulated production of TNF to basal levels.	PMC3225802
Primary microglia	5 µM	48 hours	To assess GW2580's effect on LPS-activated microglial viability. Results showed combined GW2580 and LPS treatment significantly reduced cell viability in a ROS-dependent manner.	PMC8664563
Primary microglia	5 µM	48 hours	To evaluate the effect of GW2580 on microglial proliferation. Results showed GW2580 dose-dependently inhibited CSF1-induced cell proliferation without affecting viability.	PMC8664563
Freshly isolated human monocytes	0.47 μM (IC50)	5 days	Completely inhibited CSF-1-induced growth	PMC1276040
Mouse myeloid NS0 cells	13.5 μM (IC50)		No significant effect on CSF-1-independent cell growth	PMC1276040
Mouse myeloid M-NFS-60 cells	0.33 μM (IC50)		Completely inhibited CSF-1-induced cell growth	PMC1276040

Mice	Chronic cerebral hypoperfusion model	Oral	0.1% (1000 ppm)	6 weeks	GW2580 treatment prevented the expansion of microglial numbers in chronic hypoperfused white matter, attenuated hypoperfusion-induced white matter pathology, and rescued spatial learning impairments and to a lesser extent cognitive flexibility.	PMC10952452
Mice	Chronic DRA-induced asthma model	Intranasal administration	1 ng/mouse	Twice a week for 6 weeks	Intranasal delivery of CDPL-GW nanoprobe significantly ameliorated asthma pathologies including allergen-specific serum IgE production, allergic lung and airway inflammation and airway hyper-responsiveness (AHR) with minimal pulmonary adverse reaction.	PMC7002247
C57BL/6 mice	Diabetic model	Intraperitoneal and subcutaneous implantation	10 mg/ml	Up to 15 months	Evaluate long-term anti-fibrotic effects and glycemic control of GW2580 in diabetic models	PMC7184801
Mice	Nephritis model	Oral gavage	100 mg/kg	Once daily for 10 days	GW2580 treatment ameliorated proteinuria and renal dysfunction in the nephritis model, reduced glomerular macrophage infiltration, and decreased the expression of inflammatory cytokines.	PMC4323927
C57BL/6 mice	Experimental autoimmune encephalomyelitis (EAE) model	Oral	100 mg/kg	Every 12 hours until the end of the experiment	GW2580 ameliorated the severity of EAE, reduced the proportion of macrophages in the CNS, and decreased circulating TNF levels.	PMC3225802
CX3CR1+/eGFP transgenic mice	Spinal cord injury model	Oral	150 mg/kg/day	1 week	GW2580 treatment reduced microglia proliferation, improved motor function recovery, and promoted tissue protection.	PMC8419033
Mice	Breast cancer model	Oral gavage	160 mg/kg	Daily, starting one day after tumor cell inoculation	GW2580 inhibited macrophage infiltration and function, reversing stress-enhanced metastasis	PMC2940980
C57BL/6 mice	ID8 epithelial ovarian cancer model	Oral	160 mg/kg	Once daily for 2 weeks	GW2580 treatment reduced infiltration of M2 macrophages, dramatically decreased ascites volume, and normalized the peritoneal vasculature.	PMC4675660
Athymic nude mice	Orthotopic U251 glioma model	Oral	160 mg/kg/day	Daily for two weeks	GW2580 significantly reduced tumor growth, decreased infiltration of GFP+ BMDCs in the tumor microenvironment, and reduced myeloid (Gr1+ CD11b+ and F4/80+) and angiogenic (CD202b+ and VEGFR2+) cell signatures.	PMC4686232
Mice	C3H/HEN mice and CD-1 nude mice	Oral	20 and 80 mg/kg	Twice daily for 4 days	Inhibited CSF-1-dependent tumor cell growth and macrophage accumulation	PMC1276040
Dark agouti (DA) female rats	Experimental allergic encephalomyelitis (EAE)	Oral gavage	40 mg/kg	Once daily for 11 days	GW2580 treatment delayed the onset of the disease, significantly reduced the clinical severity, and prevented the relapse phase	PMC5111339
Dark Agouti rats	Experimental Autoimmune Encephalomyelitis (EAE)	Oral gavage	40 mg/kg	Daily from day -1 to day 11 after immunization	GW2580 treatment decreased EAE clinical severity and prevents the relapse phase, reduced microglial proliferation and T-cell infiltration, and preserved BBB integrity.	PMC11941641
BALB/c mice	4T1 breast tumor model	Subcutaneous implantation	50 mg/kg	Single implantation, lasting for 10 days	To study the anti-tumor effect and immunoregulatory role of GW2580-loaded scaffolds in vivo. Results showed that GW2580-loaded scaffolds significantly reduced the proportion of M2-type macrophages in the tumor and inhibited tumor growth.	PMC9079115
Microcebus murinus	Spinal cord injury model	Oral	7.2 mg/day	2 weeks	GW2580 treatment reduced microglia proliferation, improved motor function recovery, and promoted tissue protection.	PMC8419033
Mice	Influenza A virus infection model	Oral gavage	80 mg/kg/day	Once daily for 15 days	Evaluate reversal effect of CSF1R antagonist on infection-induced oligodendrocyte transcriptional changes	PMC10439573
C57BL/6J mice	Healthy mice	Oral gavage	80 mg/kg/day	Once daily for 8 days	To evaluate GW2580's effects on microglial morphology and function in healthy mice. Results showed GW2580 altered microglial morphology without affecting cell numbers or circulating immune cell percentages. RNA-seq analysis revealed downregulation of ROS-related genes.	PMC8664563

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CAS No.: 870483-87-7

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CAS No.: 870483-87-7

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed