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Chemical Structure| 80970-09-8 Chemical Structure| 80970-09-8

Structure of H-D-Leu-NH2.HCl
CAS No.: 80970-09-8

Chemical Structure| 80970-09-8

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Synonyms: (R)-2-Amino-4-methylpentanamide hydrochloride

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Product Details of [ 80970-09-8 ]

CAS No. :80970-09-8
Formula : C6H15ClN2O
M.W : 166.65
SMILES Code : Cl[H].[H][C@@](N)(CC(C)C)C(N)=O
Synonyms :
(R)-2-Amino-4-methylpentanamide hydrochloride
MDL No. :MFCD00083640
InChI Key :VSPSRRBIXFUMOU-NUBCRITNSA-N
Pubchem ID :56776963

Safety of [ 80970-09-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 80970-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 80970-09-8 ]

[ 80970-09-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 80970-09-8 ]
  • [ 143879-80-5 ]
  • [ 1374968-91-8 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20℃; for 68h; Scheme 21[0368] To <strong>[143879-80-5]2,3,4-<strong>[143879-80-5]trifluorobenzonitrile</strong></strong> (265 mg, 1.68 mmol) in a flask, a solution of D- leucine amide hydrochloride (282 mg, 1.68 mmol) and DIEA (0.880 mL, 5.06 mmol) in DMSO (5 mL) was added. After being stirred at room temperature for 68 h, water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2S04, concentrated in vacuo. The residue was purified by a silica gel column, eluted with 0-70percent EtOAc in hexane to give (R)-2-(4-cyano-2,3-difluorophenylamino)-4-methylpentanamide (113 mg).
 

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