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Chemical Structure| 2462-32-0 Chemical Structure| 2462-32-0
Chemical Structure| 2462-32-0

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H-Phe-OBzl·HCl is a phenylalanine derivative, used for peptide synthesis and drug chemistry research.

Synonyms: L-Phenylalanine benzyl ester hydrochloride

4.5 *For Research Use Only !

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Product Details of H-Phe-OBzl·HCl

CAS No. :2462-32-0
Formula : C16H18ClNO2
M.W : 291.77
SMILES Code : Cl[H].[H][C@](N)(CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1
Synonyms :
L-Phenylalanine benzyl ester hydrochloride
MDL No. :MFCD00043249
InChI Key :CEXFHIYDTRNBJD-RSAXXLAASA-N
Pubchem ID :12636208

Safety of H-Phe-OBzl·HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of H-Phe-OBzl·HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2462-32-0 ]

[ 2462-32-0 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 2592-18-9 ]
  • [ 2462-32-0 ]
  • [ 437631-41-9 ]
  • 2
  • [ 2462-32-0 ]
  • [ 71239-85-5 ]
  • [ 935887-93-7 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20℃; for 3.16667h; To a 0 C. solution of N-<strong>[71239-85-5]Boc-L-2-pyridylalanine</strong> (050) (1.0 g, 3.76 mmol), L-phenylalanine benzyl ester hydrochloride (002) (1.3 g, 3.76 mmol), HOBT (0.68 g, 5.0 mmol) and HBTU (1.8 g, 5.0 mmol) in tetrahydrofuran (100 mL) was added a solution of N,N-diisopropylethylamine (1.6 mL) in tetrahydrofuran (10 mL). The mixture was stirred at room temperature for another 3 hours and then diluted with ethyl acetate (200 mL), washed with saturated aqueous sodium bicarbonate (2×50 mL) and brine (100 mL) and the organic layers were dried over sodium sulfate and filtered through Celite-545. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (hexane and ethyl acetate) to provide (051) (1.45 g) which was characterized by LC/MS (LCRS (MH) m/z: 504.24).
  • 3
  • [ 2462-32-0 ]
  • [ 51293-47-1 ]
  • [ 935887-75-5 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20℃; for 5.16667h; To a 0° C. solution of N-Boc serine(methyl ether) (001) (2.5 g, 11.4 mmol), L-alanine benzyl ester hydrochloride (002) (3.3 g, 11.4 mmol), HOBT (2.5 g, 18.2 mmol) and HBTU (6.9 g, 18.24 mmol) in tetrahydrofuran (400 mL) was added a solution of N,N-diisopropylethylamine (8.0 mL, 45.6 mmol) in tetrahydrofuran (50 mL) over 10 minutes. The mixture was stirred at room temperature for another 5 hours. Most of the solvents were removed under reduced pressure and the resulting material diluted with ethyl acetate (300 mL). The solution was then washed with saturated aqueous sodium bicarbonate (2.x.50 mL) and brine (100 mL). The organic layers were dried over sodium sulfate and filtered through Celite-545. The solvents were removed under reduced pressure and the residue was purified by flash chromatography (hexane and ethyl acetate), and the desired compound (003) (4.4 g) was isolated and characterized by LC/MS (LCRS (MH) m/z: 457.23).
  • 4
  • [ 2462-32-0 ]
  • [ 52558-24-4 ]
  • C24H30N2O6 [ No CAS ]
  • 5
  • [ 2462-32-0 ]
  • [ 52558-24-4 ]
  • C17H24N2O6 [ No CAS ]
 

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