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Chemical Structure| 5680-80-8 Chemical Structure| 5680-80-8
Chemical Structure| 5680-80-8

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H-Ser-OMe·HCl is a serine derivative, commonly used in peptide synthesis and drug development.

Synonyms: L-Serine methyl ester hydrochloride

4.5 *For Research Use Only !

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Product Details of H-Ser-OMe·HCl

CAS No. :5680-80-8
Formula : C4H10ClNO3
M.W : 155.58
SMILES Code : O=C(OC)[C@@H](N)CO.[H]Cl
Synonyms :
L-Serine methyl ester hydrochloride
MDL No. :MFCD00063680
InChI Key :NDBQJIBNNUJNHA-DFWYDOINSA-N
Pubchem ID :2723730

Safety of H-Ser-OMe·HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of H-Ser-OMe·HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5680-80-8 ]

[ 5680-80-8 ] Synthesis Path-Downstream   1~6

  • 2
  • [ 5680-80-8 ]
  • [ 16947-84-5 ]
  • [ 213176-46-6 ]
  • 3
  • [ 5680-80-8 ]
  • [ 51146-57-7 ]
  • methyl 3-hydroxy-2-[(2R)-2-(4-isobutylphenyl)propanoyl]amino}propanoate [ No CAS ]
  • 4
  • [ 96-81-1 ]
  • [ 5680-80-8 ]
  • N-acetyl-L-valinyl-L-serine methyl ester [ No CAS ]
  • 5
  • [ 5672-83-3 ]
  • [ 5680-80-8 ]
  • [ 359868-55-6 ]
  • 6
  • [ 59046-72-9 ]
  • [ 5680-80-8 ]
  • [ 1533409-53-8 ]
  • [ 37993-76-3 ]
YieldReaction ConditionsOperation in experiment
52%; 40% With gold(III) chloride; triethylamine; In 1,2-dichloro-ethane; at 70℃;Schlenk technique; Sealed tube; Inert atmosphere; General procedure: An oven-dried Schlenk tube with a Teflon screw valvewas charged with 1.1 equiv of L(-)Amino ester hydrochloride 2a-b,DCE (1,2-dichloroethane) (2.0 mL), 1.1 equiv Et3N, 0.5 mmol of the 2-alkanylaldehyde 1a-i, and AuCl3(10 mol %). The Schlenk tube was capped with a rubber septum and then evacuatedand backfilled with nitrogen. The septum was then replaced with a Teflon screw valve,and the Schlenk tube was sealed. The reaction mixture was heated to 70 C until2-alkanylaldehyde 1a-i had been completelyconsumed (as determined by TLC) and was allowed to cool to room temperature.The reaction mixture was diluted with ethyl acetate (10 mL) and water (15 mL).Organic layer was concentrated under reduced pressure. The crude material soobtained was purified by column chromatography on silica gel. Reaction wascarried out without Et3N when S (+) phenyl glycinol 2c isused.
 

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