Home Cart Sign in  
Chemical Structure| 489408-02-8 Chemical Structure| 489408-02-8

Structure of HBT1
CAS No.: 489408-02-8

Chemical Structure| 489408-02-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

HBT1 is a potent AMPA receptor potentiator that binds to the S518 site in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of HBT1

CAS No. :489408-02-8
Formula : C16H17F3N4O2S
M.W : 386.39
SMILES Code : O=C(C1=C(NC(CN2N=C(C(F)(F)F)C=C2C)=O)SC3=C1CCCC3)N
MDL No. :MFCD02053612
InChI Key :PHLXSNIEQIKENK-UHFFFAOYSA-N
Pubchem ID :1222102

Safety of HBT1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Isoform Comparison

Biological Activity

Description
HBT1 is a powerful potentiator of the α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R). It interacts with S518 within the ligand-binding domain (LBD) of AMPA-R, dependent on the presence of glutamate. HBT1 did not exhibit a significant bell-shaped response in the production of brain-derived neurotrophic factor (BDNF) in primary neurons[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.88mL

5.18mL

2.59mL

References

 

Historical Records

Categories