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Chemical Structure| 333357-56-5 Chemical Structure| 333357-56-5

Structure of HIF-1 inhibitor-4
CAS No.: 333357-56-5

Chemical Structure| 333357-56-5

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HIF-1 inhibitor-4 inhibits HIF-1 activity by reducing HIF-1α protein levels. It is widely used in the study of tumor metabolism regulation and diseases associated with hypoxia.

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Product Details of HIF-1 inhibitor-4

CAS No. :333357-56-5
Formula : C18H19IN2O2
M.W : 422.26
SMILES Code : O=C(NC1=CC=C(I)C=C1)C2=CC=C(CN3CCOCC3)C=C2
InChI Key :ZOFBYPLMJZJZIK-UHFFFAOYSA-N
Pubchem ID :589919

Safety of HIF-1 inhibitor-4

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of HIF-1 inhibitor-4

epigenetics

Isoform Comparison

Biological Activity

Description
HIF-1 inhibitor-4, with an IC50 value of 560 nM, selectively targets HIF-1, leading to a decrease in HIF-1α protein levels while not affecting mRNA expression.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.68mL

4.74mL

2.37mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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