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Chemical Structure| 35354-74-6 Chemical Structure| 35354-74-6

Structure of Honokiol
CAS No.: 35354-74-6

Chemical Structure| 35354-74-6

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Honokiol is a bioactive biphenolic phytochemical with potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting various signaling molecules. It inhibits Akt activation and can readily cross the blood-brain barrier.

Synonyms: NSC 293100

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Product Citations

Product Citations

Tang, Kaiqi ; Su, Han ; Qu, Zhi ;

Abstract: Background: Tongue cancer is the most common type of oral cancer, and patients have a poor prognosis and quality of life after conventional surgical treatment. Honokiol (HNK) is a kind of lignan extracted from Chinese herbal medicine Houpu, many domestic and international experiments have demonstrated its anti-tumor effect. Titanium dioxide nanotube (TNTs) is a kind of nanomaterial which can be used as drug carrier. The purpose of this study is to explore the effects of HNK-loaded TNTs delivery system (HNK-TNTs) on antitumor. Methods: TNTs were prepared by anodic oxidation method, and HNK was loaded onto TNTs by physical adsorption. The effect of HNK-TNTs on the proliferation, migration and apoptosis of CAL-27 cells were explored by CCK-8 experiment, scratch assay, live and dead staining and cellular immunofluorescence analysis. Results: The material characterization test results showed that we had successfully prepared HNK-TNTs. CCK-8 experiment, scratch assay showed that the proliferation and migration ability of CAL-27 cells were significantly weakened after treatment with HNK-TNTs, and their cell proliferation rates significantly decreased. Live/dead staining, cell immunofluorescence analysis showed that HNK-TNTs could promote CAL-27 cells apoptosis by increasing the expression levels of the apoptosis-related protein Bax and Fas. Conclusion: In this experiment, we had successfully prepared Honokiol-loaded titanium dioxide nanotube drug delivery system (HNK-TNTs) and compared the effects of single drug HNK and HNK-TNTs on the proliferation, apoptosis and migration of tongue cancer CAL-27 cells. This experiment showed that HNK-TNTs had greater antiproliferative, apoptosis-promoting and migration-inhibiting effects than the HNK as a single drug.

Keywords: titanium dioxide nanotubes (TNTs) ; Honokiol (HNK) ; tongue cancer ; apoptosis ; cell proliferation

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Product Details of Honokiol

CAS No. :35354-74-6
Formula : C18H18O2
M.W : 266.33
SMILES Code : OC1=CC=C(C=C1CC=C)C1=CC(CC=C)=CC=C1O
Synonyms :
NSC 293100
MDL No. :MFCD00016674
InChI Key :FVYXIJYOAGAUQK-UHFFFAOYSA-N
Pubchem ID :72303

Safety of Honokiol

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H318-H411
Precautionary Statements:P273-P280-P305+P351+P338+P310-P391-P501
Class:9
UN#:3077
Packing Group:

Related Pathways of Honokiol

PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • Akt

  • MEK

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06566443 Carcinoma, Non-Small-Cell Lung PHASE1 RECRUITING 2025-08-27 Houston Methodist Neal Cancer ... More >>Center, Houston, Texas, 77030, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.77mL

3.75mL

1.88mL

37.55mL

7.51mL

3.75mL

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