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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1429651-50-2 Chemical Structure| 1429651-50-2

Structure of HPOB
CAS No.: 1429651-50-2

Chemical Structure| 1429651-50-2

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HPOB is a selective inhibitor of HDAC6 with IC50 of 56 nM.

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of HPOB

CAS No. :1429651-50-2
Formula : C17H18N2O4
M.W : 314.34
SMILES Code : O=C(NO)C1=CC=C(CC(N(CCO)C2=CC=CC=C2)=O)C=C1
MDL No. :MFCD27952937
InChI Key :RFAZNTABYJYOAR-UHFFFAOYSA-N
Pubchem ID :71532921

Safety of HPOB

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H228-H315-H319
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:1325
Packing Group:

Related Pathways of HPOB

epigenetics

Isoform Comparison

Biological Activity

Target
  • HDAC8

    HDAC8, IC50:2.8 μM

  • HDAC10

    HDAC10, IC50:3.0 μM

  • HDAC3

    HDAC3, IC50:1.7 μM

  • HDAC6

    HDAC6, IC50:56 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
J-Lat cells 100 μM to 1 nM 24 hours Validation of HPOB's reactivation ability in J-Lat cells, HPOB showed high reactivation efficiency PMC7927817
Jurkat-E6-LTR-Tat-EGFP cells 100 μM to 1 nM 24 hours Screening for compounds capable of reactivating latent HIV-1, HPOB showed high reactivation efficiency and low toxicity PMC7927817
Glioblastoma (U87) 8, 16, or 32 μM 72 hours HPOB inhibited cell growth but did not induce cell death PMC3785767
Lung adenocarcinoma (A549) 8, 16, or 32 μM 72 hours HPOB inhibited cell growth but did not induce cell death PMC3785767
Human prostate adenocarcinoma (LNCaP) 8, 16, or 32 μM 72 hours HPOB inhibited cell growth but did not induce cell death PMC3785767
Human foreskin fibroblast (HFS) 8, 16, or 32 μM 72 hours HPOB inhibited cell growth but did not induce cell death PMC3785767

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice CWR22 human prostate cancer xenograft Intraperitoneal injection 100, 200, or 300 mg/kg Daily for 5 days HPOB is well-tolerated in mice and enhances the cytotoxicity of an anticancer drug PMC3785767

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.91mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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