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Chemical Structure| 1226443-41-9 Chemical Structure| 1226443-41-9

Structure of HQ461
CAS No.: 1226443-41-9

Chemical Structure| 1226443-41-9

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HQ461 is a molecular glue degrader. It acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK).

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Product Details of HQ461

CAS No. :1226443-41-9
Formula : C15H15N5OS2
M.W : 345.44
SMILES Code : O=C(CC1=CSC(NC2=CC=CC(C)=N2)=N1)NC3=NC=C(C)S3
MDL No. :MFCD16651741
InChI Key :QMRBCNQCRMTXBE-UHFFFAOYSA-N
Pubchem ID :49677967

Safety of HQ461

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Related Pathways of HQ461

Hedgehog

Isoform Comparison

Biological Activity

Description
HQ461 is a molecular glue that enhances the interaction between CDK12 and DDB1, leading to the degradation of cyclin K. This degradation disrupts CDK12 activity, reducing phosphorylation of its substrates, downregulating DNA damage response genes, and inducing cell death[1].

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2.89mL

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14.47mL

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1.45mL

28.95mL

5.79mL

2.89mL

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