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Chemical Structure| 1030203-81-6 Chemical Structure| 1030203-81-6

Structure of HS38
CAS No.: 1030203-81-6

Chemical Structure| 1030203-81-6

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HS38 is a potent inhibitor of DAPK1 and ZIPK, with Kd values of 300 nM and 280 nM, respectively, suitable for research on smooth muscle diseases and related pathologies, with potential therapeutic applications.

Synonyms: HS38

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Product Details of HS38

CAS No. :1030203-81-6
Formula : C14H12ClN5O2S
M.W : 349.80
SMILES Code : CC(SC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O)C(N)=O
Synonyms :
HS38
MDL No. :MFCD10610687
InChI Key :NASYEGAVCTZSDO-UHFFFAOYSA-N
Pubchem ID :135398509

Safety of HS38

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Isoform Comparison

Biological Activity

Description
HS38 is a potent, selective, and ATP-competitive inhibitor, targeting death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK or DAPK3) with dissociation constants (Kds) of 300 nM and 280 nM, respectively. Additionally, it acts as a PIM3 inhibitor with an IC50 of 200 nM, showing potential for smooth muscle related disorder research[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.29mL

2.86mL

1.43mL

28.59mL

5.72mL

2.86mL

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