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Chemical Structure| 1402452-15-6 Chemical Structure| 1402452-15-6

Structure of hSMG-1 inhibitor 11j
CAS No.: 1402452-15-6

Chemical Structure| 1402452-15-6

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hSMG-1 inhibitor 11j is a pyrimidine derivative that selectively inhibits hSMG-1 with an IC50 of 0.11 nM. It exhibits over 455-fold selectivity compared to mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM), and CDK1/CDK2 (IC50=32/7.1 μM), making it suitable for cancer-related research.

Synonyms: hSMG-1 inhibitor 11j

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Product Details of hSMG-1 inhibitor 11j

CAS No. :1402452-15-6
Formula : C27H28ClN7O3S
M.W : 566.07
SMILES Code : O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1Cl)(N(CC)CC)=O
Synonyms :
hSMG-1 inhibitor 11j
MDL No. :MFCD30186925

Safety of hSMG-1 inhibitor 11j

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of hSMG-1 inhibitor 11j

PI3K-AKT
Hedgehog

Isoform Comparison

Biological Activity

Description
The pyrimidine derivative hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. It demonstrates >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM), and CDK1/CDK2 (IC50=32/7.1 μM). This inhibitor can be utilized for cancer research [1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.83mL

1.77mL

0.88mL

17.67mL

3.53mL

1.77mL

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