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CAS No. :	83883-10-7
Formula :	C₁₆H₂₅NO₂
M.W :	263.38
SMILES Code :	C\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)(C)O
MDL No. :	MFCD17779317
InChI Key :	LHFKHAVGGJJQFF-UEOYEZOQSA-N
Pubchem ID :	10084135

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Rat cerebellar granule neurons	100 μM		To investigate the excitatory effects of Hydroxy-α-sanshool on central neurons, it was found to excite cerebellar granule neurons by inhibiting KCNK channels	Nat Neurosci. 2008 Jul;11(7):772-9
Mouse trigeminal ganglion neurons	100 μM		To investigate the excitatory effects of Hydroxy-α-sanshool on sensory neurons, it was found to excite neurons by inhibiting pH- and anesthetic-sensitive two-pore potassium channels (KCNK3, KCNK9, and KCNK18)	Nat Neurosci. 2008 Jul;11(7):772-9
HEK293 cells expressing TRPV1	1.1 μM (EC50)		To determine the activation effect of a-SOH on TRPV1, results showed that a-SOH effectively activated TRPV1 channels	Br J Pharmacol. 2009 Aug;157(8):1398-409
HEK293 cells expressing TRPA1	69 μM (EC50)		To determine the activation effect of a-SOH on TRPA1, results showed that a-SOH effectively activated TRPA1 channels	Br J Pharmacol. 2009 Aug;157(8):1398-409
dorsal root ganglia neurons	500 μM	5 seconds	To evaluate the activation of TRPA1 and TRPV1 channels by a-SOH, results showed that a-SOH activated neurons expressing TRPA1 and TRPV1	Br J Pharmacol. 2009 Aug;157(8):1398-409
Chinese hamster ovary cells (expressing human Nav1.1, 1.2, 1.3, 1.6, 1.7, or 1.8)	200 μM		To study the inhibitory effect of sanshool on different sodium channel subtypes, it was found that Nav1.7 and Nav1.3 currents were most significantly inhibited.	J Physiol. 2013 Jul 1;591(13):3325-40
Dorsal root ganglion (DRG) neurons	200 μM		To investigate the effect of sanshool on the electrical excitability of DRG neurons, it was found that sanshool completely inhibited AP firing in 35% of neurons and significantly reduced AP amplitude in another 29% of neurons.	J Physiol. 2013 Jul 1;591(13):3325-40
HepG2 cells	2.5, 5, 10 μg/ml	24 hours	HAS significantly increased glucose uptake and glycogen synthesis in GlcN-induced HepG2 cells and activated the PI3K/Akt pathway, increased GSK-3β phosphorylation, suppressed phosphorylation of glycogen synthase (GS), and increased glycogen synthesis in liver cells.	Front Pharmacol. 2022 Dec 13;13:1089558
trigeminal ganglion neurons	100 μM		To study the excitatory effects of sanshool on trigeminal ganglion neurons, finding that some neurons were excited by sanshool.	J Neurosci. 2010 Mar 24;30(12):4353-61
dorsal root ganglion neurons	100 μM		To study the excitatory effects of sanshool on dorsal root ganglion neurons, finding that 52% of neurons were excited by sanshool.	J Neurosci. 2010 Mar 24;30(12):4353-61
intestinal myofibroblasts (InMyoFibs)	1 μmol/L		Hydroxy-α-sanshool induced Ca2+ influx, antagonized by TRPA1-selective blocker HC-030031, indicating TRPA1 channel activation.	World J Gastroenterol. 2018 Sep 21;24(35):4036-4053

Kunming mice	Insulin resistance model	Intragastric administration	8 mg/kg·bw	Once daily for 28 days	To explore the hydroxy-alpha-sanshool (HAS) effects on the intestinal metabolites of insulin-resistant mice, the results showed that HAS intervention significantly decreased GSP, GHb, TG, and TC levels, improved gut microbiota and metabolite composition.	Foods. 2022 Jul 10;11(14):2040
Mice	TRPV1 TRPA1 double-knockout mice	Oral	1 mM	3 hours per day for 7 days	To investigate the behavioral effects of Hydroxy-α-sanshool in mice, it was found that double-knockout and wild-type mice showed the same aversion to Hydroxy-α-sanshool, indicating that TRPV1 and TRPA1 channels are not involved in its action	Nat Neurosci. 2008 Jul;11(7):772-9
Mice	TRPV1 knockout mice	Brief-access taste test	500 μM and 1 mM	30 min testing periods	To evaluate the aversive response to a-SOH, results showed that TRPV1 KO mice exhibited significantly reduced aversion to a-SOH	Br J Pharmacol. 2009 Aug;157(8):1398-409
Kunming male mice	High-fat and high-glucose diet-induced insulin resistance model	Gavage	High-dose group 12 mg/(kg·d·bw), medium-dose group 8 mg/(kg·d·bw), low-dose group 4 mg/(kg·d·bw)	Daily administration for 28 days	HAS significantly reduced fasting blood glucose, promoted insulin secretion, decreased levels of inflammatory factors, and improved hepatic steatosis.	Mol Med. 2025 Feb 21;31(1):76
C57BL/6J mice	DSS-induced ulcerative colitis model	Gavage	2.5 mg/kg/d	Once daily for 7 days	Alleviate colitis symptoms, restore intestinal barrier function, and modulate gut microbiota	Antioxidants (Basel). 2024 Jan 25;13(2):153
Mice	Neurogenic inflammation model	Topical application	50 mM (5 μL applied to the hindpaw)	Single application, effects tested 30-60 minutes post-application	To investigate the effect of sanshool on mechanical and thermal pain sensitivity, it was found that sanshool selectively attenuated mechanical hypersensitivity but had no effect on thermal sensitivity.	J Physiol. 2013 Jul 1;591(13):3325-40
C57BL/6 J mice	High-fat diet and streptozotocin (STZ)-induced type 2 diabetic mouse model	Oral	1.25, 2.5, 5 mg/kg	Once daily for 4 weeks	HAS significantly reduced fasting blood glucose, alleviated pathological changes in the liver and pancreas, increased liver glycogen content, and improved hepatic insulin resistance and increased hepatic glycogen synthesis by activating the PI3K/Akt/GSK-3β/GS signaling pathway.	Front Pharmacol. 2022 Dec 13;13:1089558
C57BL/6 mice		Drinking water	1 mM	3 h every 24 h for 4-5 days	To study the effects of sanshool on drinking behavior in mice, finding that sanshool significantly reduced water consumption.	J Neurosci. 2010 Mar 24;30(12):4353-61
Sprague Dawley (SD) rats		Oral administration	10 mg/kg	Single dose	To study the pharmacokinetic properties of HAS in rats, results showed that HAS was rapidly absorbed in rats with a Tmax of 0.75 h, Cmax of 1253 ng/mL, and T1/2 of 1.02 h.	Toxics. 2024 Jan 24;12(2):100

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CAS No.: 83883-10-7

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CAS No.: 83883-10-7

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Product Details of Hydroxy-α-sanshool

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Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.80mL 0.76mL 0.38mL	18.98mL 3.80mL 1.90mL	37.97mL 7.59mL 3.80mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed