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Chemical Structure| 138926-19-9 Chemical Structure| 138926-19-9

Structure of Ibandronate sodium monohydrate
CAS No.: 138926-19-9

Chemical Structure| 138926-19-9

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Ibandronate sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

Synonyms: BM-210955; RPR-102289A; Sodium trihydrogen (1-hydroxy-3-(methylpentylamino)propylidene)diphosphonate, monohydrate

4.5 *For Research Use Only !

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Product Details of Ibandronate sodium monohydrate

CAS No. :138926-19-9
Formula : C9H24NNaO8P2
M.W : 359.23
SMILES Code : O=P(C(O)(P(O)([O-])=O)CCN(C)CCCCC)(O)O.[H]O[H].[Na+]
Synonyms :
BM-210955; RPR-102289A; Sodium trihydrogen (1-hydroxy-3-(methylpentylamino)propylidene)diphosphonate, monohydrate
MDL No. :MFCD00912167
InChI Key :VBDRTGFACFYFCT-UHFFFAOYSA-M
Pubchem ID :23663991

Safety of Ibandronate sodium monohydrate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314-H373-H410
Precautionary Statements:P260-P264-P270-P273-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P314-P363-P391-P405-P501
Class:8
UN#:1759
Packing Group:

Isoform Comparison

Biological Activity

Description
Ibandronate Sodium Monohydrate is a potent nitrogen-containing bisphosphonate, primarily utilized in the treatment of osteoporosis. It operates by targeting the bone metabolism to prevent bone loss. In research focused on endothelial cells, Ibandronate at concentrations between 1.25 and 2 μM notably reduces cell growth. At 2 μM, it also significantly hampers the formation of capillary-like structures and induces apoptosis in these cells. Furthermore, Ibandronate increases VEGF expression in endothelial cells in a dose-dependent manner when administered at concentrations below 100 μM[1].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01627886 Healthy PHASE1 COMPLETED 2025-10-08 BA Research India Ltd, Ahmedab... More >>ad, Gujarat, 380 054, India Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.92mL

2.78mL

1.39mL

27.84mL

5.57mL

2.78mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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