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Chemical Structure| 316146-57-3 Chemical Structure| 316146-57-3

Structure of ICA-105574
CAS No.: 316146-57-3

Chemical Structure| 316146-57-3

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ICA-105574 is an effective hERG channel activator that enhances hERG channel activity by eliminating channel inactivation, significantly increasing current amplitude by over 10 times, with an EC50 of 0.5 μM, suitable for studies related to cardiac electrophysiology and drug safety.

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Product Details of ICA-105574

CAS No. :316146-57-3
Formula : C19H14N2O4
M.W : 334.33
SMILES Code : O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3
MDL No. :N/A

Safety of ICA-105574

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

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Biological Activity

Description
ICA-105574 is a powerful and effective activator of hERG channels. Its primary mechanism of action involves eliminating hERG channel inactivation. ICA-105574 significantly enhances current amplitudes by over 10-fold, with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2 [1].

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.96mL

2.99mL

1.50mL

29.91mL

5.98mL

2.99mL

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