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Chemical Structure| 3519-82-2 Chemical Structure| 3519-82-2

Structure of INCA-6
CAS No.: 3519-82-2

Chemical Structure| 3519-82-2

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INCA-6 is a selective inhibitor of calcineurin-NFAT (nuclear factor of activated T cells) signaling.

Synonyms: Triptycene-1,4-quinone; NFAT Activation Inhibitor III; NSC 25996

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Product Details of INCA-6

CAS No. :3519-82-2
Formula : C20H12O2
M.W : 284.31
SMILES Code : O=C1C=CC(C2=C1C3C4=CC=CC=C4C2C5=CC=CC=C35)=O
Synonyms :
Triptycene-1,4-quinone; NFAT Activation Inhibitor III; NSC 25996
MDL No. :MFCD00226933

Safety of INCA-6

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Cl.7W2 T cells 10-40 μM INCA-6 blocked NFAT dephosphorylation in a concentration-dependent manner, with partial blockade at 10 μM, nearly complete at 20 μM, and total at 40 μM PMC419644

Protocol

Bio Calculators
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3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL

 

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