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Chemical Structure| 1207660-00-1 Chemical Structure| 1207660-00-1

Structure of Indophagolin
CAS No.: 1207660-00-1

Chemical Structure| 1207660-00-1

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Indophagolin is an autophagy inhibitor that antagonizes various purinergic and serotonin receptors.

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Product Details of Indophagolin

CAS No. :1207660-00-1
Formula : C19H15BrClF3N2O3S
M.W : 523.75
SMILES Code : O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O
MDL No. :MFCD14721653
InChI Key :OGXJZCDFFBDSJJ-UHFFFAOYSA-N
Pubchem ID :46504926

Safety of Indophagolin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

Description
Indophagolin is a potent autophagy inhibitor containing indoline (IC50=140 nM). It antagonizes the purinergic receptors P2X4, P2X1, and P2X3 with IC50 values of 2.71, 2.40, and 3.49 μM, respectively. Additionally, Indophagolin antagonizes Gq-protein-coupled receptors P2Y4, P2Y6, and P2Y11 (IC50s =3.4~15.4 μM). It exhibits a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.91mL

0.38mL

0.19mL

9.55mL

1.91mL

0.95mL

19.09mL

3.82mL

1.91mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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