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Chemical Structure| 607742-69-8 Chemical Structure| 607742-69-8

Structure of Intepirdine
CAS No.: 607742-69-8

Chemical Structure| 607742-69-8

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SB-742457 is a selective 5-HT6 receptor antagonist with Ki value of 1.4 nM, showing potential cognition, memory, and learning-enhancing effects.

Synonyms: SB-742457; GSK-742457; RVT101. intepirdine.

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Product Details of Intepirdine

CAS No. :607742-69-8
Formula : C19H19N3O2S
M.W : 353.44
SMILES Code : O=S(C1=CC2=CC=CC(N3CCNCC3)=C2N=C1)(C4=CC=CC=C4)=O
Synonyms :
SB-742457; GSK-742457; RVT101. intepirdine.
MDL No. :MFCD12828872
InChI Key :JJZFWROHYSMCMU-UHFFFAOYSA-N
Pubchem ID :11256720

Safety of Intepirdine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Intepirdine

GPCR

Isoform Comparison

Biological Activity

Target
  • 5-HT6

    5-HT6, pKi:9.63

In Vitro:

Cell Line
Concentration Treated Time Description References
NG108-15 cells 1 μM 24 h Evaluate the effect of Intepirdine on 5-HT6R-mediated Cdk5 signaling, results showed Intepirdine reduced neurite length PMC10641814

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Rats Aβ-induced memory deficit model Intraperitoneal injection 1.5 mg/kg Twice daily for 7 days Evaluate the effect of Intepirdine on Aβ-induced memory deficits, results showed Intepirdine partially reversed memory deficits PMC10641814

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00224497 Alzheimer's Disease PHASE2 COMPLETED - GSK Investigational Site, Hall... More >> in Tirol, A-6060, Austria|GSK Investigational Site, Innsbruck, A-6020, Austria|GSK Investigational Site, Retz, A-2070, Austria|GSK Investigational Site, Vienna, A-1040, Austria|GSK Investigational Site, Vienna, A-1130, Austria|GSK Investigational Site, Plovdiv, 4000, Bulgaria|GSK Investigational Site, Sofia, 1113, Bulgaria|GSK Investigational Site, Sofia, 1431, Bulgaria|GSK Investigational Site, Sofia, 1527, Bulgaria|GSK Investigational Site, Varna, 9010, Bulgaria|GSK Investigational Site, Providencia / Santiago, Región Metro De Santiago, 7500710, Chile|GSK Investigational Site, Santiago, Región Metro De Santiago, Chile|GSK Investigational Site, Valparaiso, Valparaíso, 2352499, Chile|GSK Investigational Site, Split, 21000, Croatia|GSK Investigational Site, Zagreb, 10000, Croatia|GSK Investigational Site, Olomouc, 775 20, Czech Republic|GSK Investigational Site, Ostrava, 702 00, Czech Republic|GSK Investigational Site, Praha 5, 150 18, Czech Republic|GSK Investigational Site, Rychnov Nad Kneznou, 516 01, Czech Republic|GSK Investigational Site, Athens, 115 21, Greece|GSK Investigational Site, Athens, 151 23, Greece|GSK Investigational Site, Melissia, 151 27, Greece|GSK Investigational Site, Thessaloniki, 57010, Greece|GSK Investigational Site, Seoul, 135-710, Korea, Republic of|GSK Investigational Site, Seoul, 150-719, Korea, Republic of|GSK Investigational Site, Auckland, 1309, New Zealand|GSK Investigational Site, Christchurch, 8002, New Zealand|GSK Investigational Site, Mosina, 62-050, Poland|GSK Investigational Site, Olsztyn, 10-082, Poland|GSK Investigational Site, Warszawa, 02-097, Poland|GSK Investigational Site, Moscow, 115522, Russian Federation|GSK Investigational Site, Moscow, 117049, Russian Federation|GSK Investigational Site, St.-Petersburg, 198103, Russian Federation|GSK Investigational Site, Bratislava, 811 01, Slovakia|GSK Investigational Site, Bratislava, 811 07, Slovakia|GSK Investigational Site, Bratislava, 811 08, Slovakia|GSK Investigational Site, Bratislava, 826 06, Slovakia|GSK Investigational Site, Kosice, 041 66, Slovakia|GSK Investigational Site, Rimavska Sobota, 979 12, Slovakia|GSK Investigational Site, Oakdale, 7530, South Africa|GSK Investigational Site, Rosebank, 2196, South Africa|GSK Investigational Site, Somerset West, 7130, South Africa|GSK Investigational Site, Barcelona, 08003, Spain|GSK Investigational Site, Barcelona, 08014, Spain|GSK Investigational Site, Barcelona, 08025, Spain|GSK Investigational Site, Madrid, 28046, Spain|GSK Investigational Site, Sant Cugat Del Vallés/, 08190, Spain|GSK Investigational Site, Tarrasa, Barcelona, 08221, Spain Less <<
NCT00551772 Alzheimer's Disease PHASE1 COMPLETED - GSK Investigational Site, Evan... More >>sville, Indiana, 47714, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.15mL

2.83mL

1.41mL

28.29mL

5.66mL

2.83mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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