Irinotecan HCl trihydrate | Topoisomerase I Inhibitor

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	136572-09-3
Formula :	C₃₃H₄₅ClN₄O₉
M.W :	677.18
SMILES Code :	O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3.[H]Cl.[H]O[H].[H]O[H].[H]O[H]
Synonyms :	CPT-11 hydrochloride trihydrate; Irinotecan(hydrochloride hydrate); CPT-11 HCl Trihydrate
MDL No. :	MFCD01765731
InChI Key :	KLEAIHJJLUAXIQ-JDRGBKBRSA-N
Pubchem ID :	60837

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P501-P270-P264-P301+P310+P330-P405
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Description	Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate), a potent topoisomerase I inhibitor, exhibits antitumor properties[1].
Target	Topo I

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CAS No.: 136572-09-3

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CAS No.: 136572-09-3

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C2C12 cells	50 μg/mL	1 h	To evaluate the effect of SR12343 on FOLFIRI-induced markers of cellular senescence. SR12343 significantly reduced the expression levels of p53, p21, Tnfa, and Il1a.	PMC10906225
HT-29	20 µM	1.5 h	To investigate the effects of irinotecan alone or in combination with 5-FU on the growth, metabolic activity, proliferation, and clonogenic survival of HT-29 cells. Results showed that irinotecan alone or in combination with 5-FU significantly inhibited the growth, metabolic activity, and clonogenic survival of HT-29 cells, and significantly increased the radiosensitivity of tumor cells.	PMC10299222
EC-109	0–125 μM	48 h	To evaluate the inhibitory effect of Irinotecan on the proliferation of EC-109 cells, the results showed that Irinotecan significantly inhibited cell proliferation at micromolar concentrations.	PMC5981453
KYSE-450	0–125 μM	48 h	To evaluate the inhibitory effect of Irinotecan on the proliferation of KYSE-450 cells, the results showed that Irinotecan significantly inhibited cell proliferation at micromolar concentrations.	PMC5981453
LAN-1	100, 10, 1 nM	72 h	To study the cytotoxicity of SN-38, results showed that all SN-38-loaded NPs retained activity in the low nanomolar concentration range	PMC5564453
HeLa	100, 10, 1 nM	72 h	To study the cytotoxicity of SN-38, results showed that all SN-38-loaded NPs retained activity in the low nanomolar concentration range	PMC5564453
293T cells	10 µM	24 h	Increased the proportion of cells in S and G2/M phases, promoting CRISPR/Cas9-mediated homology-directed repair (HDR) efficiency	PMC10676593
BHK-21 cells	1-10 µM	48 h	Dose-dependent increase in dsDNA and ssODN-mediated knock-in (KI) efficiency	PMC10676593
pig fetal fibroblasts (PFFs)	1-10 µM	48 h	Dose-dependent increase in knock-in (KI) efficiency	PMC10676593
SW480 cells	10 μM	48 h	To evaluate the effect of Irinotecan on SW480 cells, results showed decreased cell viability after Irinotecan treatment.	PMC6947904
U87 cells	10 μM	72 h	Irinotecan showed anti-GBM activity in U87 cells with an IC50 value lower than other compounds.	PMC3898565
SK72 cells	30 μM		Irinotecan showed anti-GBM activity in SK72 cells with an IC50 value of 30 μM.	PMC3898565

Mice	C57BL/6J mice	Intraperitoneal injection	24 mg/kg	3 times per week for 9 weeks	To evaluate the effect of FOLFIRI on, lean mass, and fat mass in mice. FOLFIRI significantly reduced, lean mass, and fat mass, and increased the expression of markers of cellular senescence.	PMC10906225
Mice	C57BL/6 mice	Intravenous injection	40 mg/kg	Every 3 or 4 days for 4 to 6 administrations	In the orthotopic MC38 tumor model, the Ir-silicasome demonstrated improved pharmacokinetics and tumor drug content compared to free drug and Onivyde?, significantly enhancing therapeutic efficacy, prolonging survival, and reducing bone marrow and gastrointestinal toxicity.	PMC6554030
BALB/c nude mice	subcutaneous xenograft model	intraperitoneal injection	5 mg/kg	twice per week, for approximately 50 days	To study the role of eIF3a in irinotecan sensitivity in vivo, it was found that eIF3a silencing significantly increased tumor resistance to irinotecan.	PMC9055905
NOD/SCID mice	ESCC cell line xenograft models	Intraperitoneal injection	8 mg/kg	Twice a week for 3 weeks	To evaluate the antitumor effect of Irinotecan in ESCC xenograft models, the results showed that Irinotecan significantly inhibited tumor growth, but the effect was inferior to Gimatecan.	PMC5981453
pig	pig embryos	embryo injection	5 µM	single injection, incubated for 6 days	Significantly increased knock-in (KI) frequency in pig embryos without impairing embryo development	PMC10676593
Nude mice	U87 cell subcutaneous xenograft model	Intraperitoneal injection	0.5 mg/kg	Once daily for 5 days, followed by 2 days off	The combination of irinotecan with pitavastatin significantly inhibited tumor growth with lower toxicity.	PMC3898565

NCT00483834	Colorectal Cancer	Phase 2	Completed	-	Canada, Ontario ... More >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT03245450	Refractory or Recurrent Solid ... More >>Tumors Rhabdomyosarcoma Non-Rhabdomyosarcoma Soft Tissue Sarcoma Ewing Sarcoma Less <<	Phase 1 Phase 2	Recruiting	June 30, 2021	Germany ... More >> Uniklinik RWTH Aachen Kinderklinik Recruiting Aachen, Germany Charite Virchow Kinderklinik - CC17 Recruiting Berlin, Germany Uniklinik Essen AoR Kinderklinik Recruiting Essen, Germany Klinik fur Kinder und Jugendmed - KKJM Recruiting Frankfurt, Germany Uniklinik Freiburg Kindermedizin Klinik IV Recruiting Freiburg, Germany Uniklinik Gottingen Kindermedizin Recruiting Gottingen, Germany Kinderklinik Muenchen Schwabing Not yet recruiting Muenchen, Germany Less <<
NCT02015754	Colorectal Cancer	Phase 2	Completed	-	United States, Maryland ... More >> The Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 Less <<
NCT03175016	Colon Cancer Liver Metastasis	Phase 2 Phase 3	Recruiting	December 2019	China, Tianjin ... More >> Tianjin Medical University Cancer Institute and Hospital Recruiting Tianjin, Tianjin, China, 300060 Contact: Zhi Guo, MD 13920076145 cjr.guozhi@vip.163.com Contact: Xueling Yang, MD 15620930669 yxueling123@163.com Sub-Investigator: Wenge Xing Less <<
NCT00540943	Neoplasms, Colorectal	Phase 1	Completed	-	France ... More >> GSK Investigational Site Saint Herblain, France, 44805 GSK Investigational Site Toulouse, France, 31052 Less <<
NCT00003225	Colorectal Cancer	Phase 1 Phase 2	Completed	-	United States, California ... More >> Jonsson Comprehensive Cancer Center, UCLA Los Angeles, California, United States, 90095-1781 Wilshire Oncology Medical Group, Inc. Rancho Cucamonga, California, United States, 91730 Less <<
NCT01494506	Metastatic Pancreatic Cancer	Phase 3	Completed	-	-
NCT00393094	High-Grade Gliomas	Phase 2	Terminated(Terminated due to t... More >>he limitations of accrual.) Less <<	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01494506	-		Completed	-	-
NCT02015754	-		Completed	-	-
NCT00004919	Unspecified Childhood Solid Tu... More >>mor, Protocol Specific Less <<	Phase 1	Completed	-	United States, California ... More >> COG Phase I Consortium Arcadia, California, United States, 91006-3776 Less <<
NCT00393094	-		Terminated(Terminated due to t... More >>he limitations of accrual.) Less <<	-	-
NCT00693719	Breast Cancer	Phase 2	Completed	-	United States, Arizona ... More >> Arizona Cancer Center at University of Arizona Health Sciences Center Tucson, Arizona, United States, 85724-5024 Less <<
NCT00160875	Esophageal Cancer	Phase 2 Phase 3	Completed	-	Canada, Ontario ... More >> University Health Network Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00693719	-		Completed	-	-

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed