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Chemical Structure| 1337529-56-2 Chemical Structure| 1337529-56-2

Structure of 1337529-56-2

Chemical Structure| 1337529-56-2

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Product Details of [ 1337529-56-2 ]

CAS No. :1337529-56-2
Formula : C18H17F5NO5P
M.W : 453.30
SMILES Code : C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC2=C(F)C(F)=C(F)C(F)=C2F)=O

Safety of [ 1337529-56-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H317-H334
Precautionary Statements:P261-P272-P280-P284-P302+P352-P304+P340-P333+P313-P342+P311-P362+P364-P501

Application In Synthesis of [ 1337529-56-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1337529-56-2 ]

[ 1337529-56-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1337529-56-2 ]
  • [ 114248-23-6 ]
  • isopropyl ((S)-(((2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate [ No CAS ]
YieldReaction ConditionsOperation in experiment
22% Commercial 2?-deoxy-2?-difluorouridine (132mg) was dissolved in dry THF (5mL) under nitrogen.The solution was cooled to -10C and to it added slowly t-BuMgCl (1M solution in THF, 2.1 eq.). Theresulting slurry was stirred for 1h and 10a (272mg) (Ross, B. S.; Reddy, P. G.; Zhang, H-R.;Rachakonda, S.; Sofia, M. J. J. Org. Chem. 2011;76:8311) added as a solution in dry THF (2mL). Thereaction was then stirred at 0C for 5h and quenched by addition of saturated ammonium chloridesolution. Ethyl acetate (10mL) was added and the phases separated. The water layer was extractedwith ethyl acetate (3x10mL) and the combined organic layers dried over sodium sulphate. Evaporationafforded a residue that was purified by chromatography on silica-gel using DCM/MeOH: 95/5 toyield, after evaporation the desired product (isopropyl ((S)-(((2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate, 3) as a white solid (60mg, 22%).
  • 2
  • [ 1337529-56-2 ]
  • [ 20724-73-6 ]
  • C22H31N4O9P [ No CAS ]
 

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