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Chemical Structure| 75695-93-1 Chemical Structure| 75695-93-1

Structure of Isradipine
CAS No.: 75695-93-1

Chemical Structure| 75695-93-1

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Isradipine is a potent L-type calcium channel selective blocker with an IC50 of 34±8 μM.

Synonyms: PN 200-110

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Product Details of Isradipine

CAS No. :75695-93-1
Formula : C19H21N3O5
M.W : 371.39
SMILES Code : O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC3=NON=C32)OC
Synonyms :
PN 200-110
MDL No. :MFCD00153820
InChI Key :HMJIYCCIJYRONP-UHFFFAOYSA-N
Pubchem ID :3784

Safety of Isradipine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • Calcium Channel

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03538262 - Enrolling by invitation January 31, 2023 United States, New York ... More >> CHeT Telemedicine (Site 363) Rochester, New York, United States, 14642 Less <<
NCT00684489 Hypertension Not Applicable Completed - -
NCT01587742 - Completed - -
NCT00733239 Opioid Dependence Phase 1 Completed - United States, Arkansas ... More >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Less <<
NCT01007994 Hypertension Secondary to Kidn... More >>ey Transplant Less << Phase 2 Phase 3 Active, not recruiting December 2018 United States, New York ... More >> Cohen Children's Medical Center of NY New Hyde Park, New York, United States, 11040 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT02136823 Chronic Spinal Cord Injury Not Applicable Unknown - -
NCT00909545 Parkinson Disease Phase 2 Completed - United States, California ... More >> Parkinson Institute Sunnyvale, California, United States, 94805 United States, Connecticut Institute for Neurodegenerative Disorders New Haven, Connecticut, United States, 06510 United States, Florida Mayo Clinic Jacksonville Jacksonville, Florida, United States, 32224 University of Miami Miami, Florida, United States, 33136 University of South Flordia Tampa, Florida, United States, 33606 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30329 United States, Hawaii Pacific Health Institute Honolulu, Hawaii, United States, 96817 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Massachusetts Boston University Boston, Massachusetts, United States, 02118 United States, Michigan Michigan State University East Lansing, Michigan, United States, 48824 United States, Minnesota Park Nicolet Clinic Golden Valley, Minnesota, United States, 55427 University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, New York University of Rochester Rochester, New York, United States, 14618 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45219 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee University of Tennessee Memphis, Tennessee, United States, 38104 Canada, Ontario Ottowa Hospital Civic Site Ottawa, Ontario, Canada, K1Y 4E9 Toronto Western Hospital Toronto, Ontario, Canada, M5T 2S8 Less <<
NCT03083353 Nicotine Dependence Early Phase 1 Suspended(The study is being m... More >>odified to address low recruitment.) Less << January 2022 United States, Texas ... More >> University of Texas at Austin Austin, Texas, United States, 78712 Less <<
NCT00593463 Drug Dependence Phase 1 Completed - United States, Arkansas ... More >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 Less <<
NCT01895270 Opioid Dependence Phase 1 Phase 2 Completed - United States, Arkansas ... More >> UAMS Psychiatric Research Institute Little Rock, Arkansas, United States, 72205 Less <<
NCT00909545 - Completed - -
NCT01895270 - Completed - -
NCT01658150 - Completed - -
NCT00753636 - Completed - -
NCT01784666 Bipolar Disorder Phase 2 Terminated(Lack of Enrollment) - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT01658150 Schizophrenia ... More >> Schizoaffective Disorder Less << Not Applicable Completed - United States, New York ... More >> Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Less <<
NCT01784666 - Terminated(Lack of Enrollment) - -
NCT00753636 Parkinson's Disease Phase 2 Completed - United States, Illinois ... More >> 710 N. Lake Shore Dr. Chicago, Illinois, United States, 60610 Less <<
NCT02168842 Parkinson Disease Phase 3 Active, not recruiting March 2019 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.93mL

5.39mL

2.69mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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