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Chemical Structure| 749269-83-8 Chemical Structure| 749269-83-8

Structure of Itanapraced
CAS No.: 749269-83-8

Chemical Structure| 749269-83-8

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CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

Synonyms: CHF5074; CSP-1103; CS 1103

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Product Details of Itanapraced

CAS No. :749269-83-8
Formula : C16H11Cl2FO2
M.W : 325.16
SMILES Code : O=C(C1(C2=CC=C(C3=CC=C(Cl)C(Cl)=C3)C(F)=C2)CC1)O
Synonyms :
CHF5074; CSP-1103; CS 1103
MDL No. :MFCD18633206

Safety of Itanapraced

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P264-P270-P301+P312-P330

Isoform Comparison

Biological Activity

Description
Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. It reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively, and prevents cell apoptosis in hippocampal neurons caused by oxygen and glucose deprivation (OGD). Itanapraced is researched for potential use in Alzheimer's disease treatment[1][2].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.38mL

3.08mL

1.54mL

30.75mL

6.15mL

3.08mL

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