Structure of Ivosidenib
CAS No.: 1448347-49-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Ivosidenib is a selective IDH1 (isocitrate dehydrogenase 1) inhibitor with high affinity for the IDH1 R132H mutant. Ivosidenib is primarily used for the treatment of acute myeloid leukemia (AML) and other related tumors with IDH1 mutations.
Synonyms: AG-120; Invosidenib
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1448347-49-6 |
Formula : | C28H22ClF3N6O3 |
M.W : | 582.96 |
SMILES Code : | O=C([C@H](CC1)N(C2=NC=CC(C#N)=C2)C1=O)N([C@@H](C3=CC=CC=C3Cl)C(NC4CC(F)(F)C4)=O)C5=CC(F)=CN=C5 |
Synonyms : |
AG-120; Invosidenib
|
MDL No. : | MFCD29036964 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
C2C12 myotubes | 93 μM | 5 days | To evaluate the effect of D2HG on myotube atrophy, results showed that D2HG treatment led to reduced myotube diameter and significantly increased mRNA expression of E3 ligases Trim63 and Fbxo32. | PMC10518016 |
GBC5 PDO | 10 µM, 50 µM | 96 h | To evaluate the inhibitory effect of Ivosidenib on the growth of GBC5 PDO. Results showed that Ivosidenib did not significantly affect the growth of GBC5 PDO. | PMC8487492 |
THP-1 cells | 5 µM | 72 h | To evaluate the sensitivity of IDH1-mutant AML cells to complex I inhibitors, results showed significantly increased sensitivity to IACS-010759 in IDH1-mutant cells. | PMC9098909 |
MOLM14 IDH1 R132H | 2 µM | 1 week | Evaluate the effect of IDH1 mutant inhibitor on mitochondrial metabolism, results showed maintenance or enhancement of mitochondrial metabolism | PMC7995203 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
mice | CT26 colorectal carcinoma models and GL261 glioma model | intravenous | 50 mg/kg | daily for the experimental period | To evaluate the effect of Ivosidenib on alleviating IDH1 mutation-mediated cancer cachexia, results showed that Ivosidenib delayed the progression of cachexia and preserved skeletal muscle mass. | PMC10518016 |
M-NSG mice | subcutaneous ICC model | gavage | 150 mg/kg | once every 3 days, for 3 times | To evaluate the inhibitory effect of AdHNF4α and ivosidenib combination therapy on ICC, results showed that the combination therapy significantly suppressed tumor growth | PMC11802383 |
Mice | AML PDX models | Oral gavage | 150 mg/kg AG-120, 6 mg/kg IACS-010759 | AG-120 twice daily for 3 weeks; IACS-010759 every other day for 3 weeks | Evaluate the anti-leukemic efficacy of IDH1 mutant inhibitor combined with mitochondrial inhibitors, showing significant reduction in tumor burden and enhanced differentiation | PMC7995203 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT06081829 | Cholangiocarcinoma Non-resecta... More >>ble|Cholangiocarcinoma Metastatic Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-05-27 | National Cancer Center Hospita... More >>l East (JPN-002), Kashiwa, 277-8577, Japan|Kumamoto University Hospital (JPN-004), Kumamoto, 860-8556, Japan|National Hospital Organization Shikoku Cancer Center (JPN-007), Matsuyama, 791-0280, Japan|Osaka International Cancer Institute (JPN-005), Osaka, 541-8567, Japan|Hokkaido University Hospital (JPN-006), Sapporo, 060-8648, Japan|National Cancer Center Hospital (JPN-001), Tokyo, Japan|Kanagawa Cancer Center (JPN-003), Yokohama, 241-8515, Japan Less << |
NCT06181734 | Acute Myeloid Leukemia (AML) | RECRUITING | 2028-12-30 | Praxis für interdisziplin?re O... More >>nkologie & H?matologie, Freiburg, Germany Less << | |
NCT03564821 | IDH1 Mutation Myeloid Neoplasm... More >>s Less << | PHASE1 | COMPLETED | 2023-06-06 | Johns Hopkins Cancer Center, B... More >>altimore, Maryland, 21218, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Massachusetts General Hospital, Boston, Massachusetts, 02214, United States|Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States Less << |
NCT05030441 | Clonal Cytopenia of Undetermin... More >>ed Significance Less << | PHASE2 | RECRUITING | 2030-01-31 | Washington University School o... More >>f Medicine, Saint Louis, Missouri, 63110, United States|Northwell Health Cancer Institute (R.J. Zuckerberg Cancer Center), Lake Success, New York, 11042, United States|Memorial Sloan Kettering, New York, New York, 10065, United States|Cleveland Clinic - Case Comprehensive Cancer Center, Cleveland, Ohio, 44195, United States|Ohio State University, Columbus, Ohio, 43210, United States Less << |
NCT04195555 | Recurrent Ependymoma|Recurrent... More >> Ewing Sarcoma|Recurrent Hepatoblastoma|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Glioma|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Recurrent WHO Grade 2 Glioma|Refractory Ependymoma|Refractory Ewing Sarcoma|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Glioma|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma|Refractory WHO Grade 2 Glioma|Wilms Tumor Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-03-31 | Children's Hospital of Alabama... More >>, Birmingham, Alabama, 35233, United States|Providence Alaska Medical Center, Anchorage, Alaska, 99508, United States|Banner Children's at Desert, Mesa, Arizona, 85202, United States|Phoenix Childrens Hospital, Phoenix, Arizona, 85016, United States|Banner University Medical Center - Tucson, Tucson, Arizona, 85719, United States|Arkansas Children's Hospital, Little Rock, Arkansas, 72202-3591, United States|Kaiser Permanente Downey Medical Center, Downey, California, 90242, United States|City of Hope Comprehensive Cancer Center, Duarte, California, 91010, United States|Loma Linda University Medical Center, Loma Linda, California, 92354, United States|Miller Children's and Women's Hospital Long Beach, Long Beach, California, 90806, United States|Children's Hospital Los Angeles, Los Angeles, California, 90027, United States|Cedars Sinai Medical Center, Los Angeles, California, 90048, United States|Mattel Children's Hospital UCLA, Los Angeles, California, 90095, United States|Valley Children's Hospital, Madera, California, 93636, United States|UCSF Benioff Children's Hospital Oakland, Oakland, California, 94609, United States|Kaiser Permanente-Oakland, Oakland, California, 94611, United States|Children's Hospital of Orange County, Orange, California, 92868, United States|Lucile Packard Children's Hospital Stanford University, Palo Alto, California, 94304, United States|University of California Davis Comprehensive Cancer Center, Sacramento, California, 95817, United States|Rady Children's Hospital - San Diego, San Diego, California, 92123, United States|Naval Medical Center -San Diego, San Diego, California, 92134, United States|UCSF Medical Center-Mission Bay, San Francisco, California, 94158, United States|Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, 90502, United States|Children's Hospital Colorado, Aurora, Colorado, 80045, United States|Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado, 80218, United States|Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States|Yale University, New Haven, Connecticut, 06520, United States|Alfred I duPont Hospital for Children, Wilmington, Delaware, 19803, United States|MedStar Georgetown University Hospital, Washington, District of Columbia, 20007, United States|Children's National Medical Center, Washington, District of Columbia, 20010, United States|Broward Health Medical Center, Fort Lauderdale, Florida, 33316, United States|Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida, 33908, United States|University of Florida Health Science Center - Gainesville, Gainesville, Florida, 32610, United States|Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida, 33021, United States|Nemours Children's Clinic-Jacksonville, Jacksonville, Florida, 32207, United States|University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, 33136, United States|Nicklaus Children's Hospital, Miami, Florida, 33155, United States|Miami Cancer Institute, Miami, Florida, 33176, United States|AdventHealth Orlando, Orlando, Florida, 32803, United States|Arnold Palmer Hospital for Children, Orlando, Florida, 32806, United States|Nemours Children's Hospital, Orlando, Florida, 32827, United States|Sacred Heart Hospital, Pensacola, Florida, 32504, United States|Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, 33701, United States|Tampa General Hospital, Tampa, Florida, 33606, United States|Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida, 33607, United States|Saint Mary's Medical Center, West Palm Beach, Florida, 33407, United States|Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, 30329, United States|Memorial Health University Medical Center, Savannah, Georgia, 31404, United States|Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, 96826, United States|Saint Luke's Cancer Institute - Boise, Boise, Idaho, 83712, United States|Lurie Children's Hospital-Chicago, Chicago, Illinois, 60611, United States|University of Illinois, Chicago, Illinois, 60612, United States|University of Chicago Comprehensive Cancer Center, Chicago, Illinois, 60637, United States|Loyola University Medical Center, Maywood, Illinois, 60153, United States|Saint Jude Midwest Affiliate, Peoria, Illinois, 61637, United States|Southern Illinois University School of Medicine, Springfield, Illinois, 62702, United States|Riley Hospital for Children, Indianapolis, Indiana, 46202, United States|Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana, 46260, United States|Blank Children's Hospital, Des Moines, Iowa, 50309, United States|University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, 52242, United States|University of Kentucky/Markey Cancer Center, Lexington, Kentucky, 40536, United States|Norton Children's Hospital, Louisville, Kentucky, 40202, United States|Children's Hospital New Orleans, New Orleans, Louisiana, 70118, United States|Ochsner Medical Center Jefferson, New Orleans, Louisiana, 70121, United States|Eastern Maine Medical Center, Bangor, Maine, 04401, United States|Maine Children's Cancer Program, Scarborough, Maine, 04074, United States|University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, 21201, United States|Sinai Hospital of Baltimore, Baltimore, Maryland, 21215, United States|Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, 21287, United States|National Institutes of Health Clinical Center, Bethesda, Maryland, 20892, United States|Massachusetts General Hospital Cancer Center, Boston, Massachusetts, 02114, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|UMass Memorial Medical Center - University Campus, Worcester, Massachusetts, 01655, United States|C S Mott Children's Hospital, Ann Arbor, Michigan, 48109, United States|Children's Hospital of Michigan, Detroit, Michigan, 48201, United States|Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, 48201, United States|Michigan State University Clinical Center, East Lansing, Michigan, 48824, United States|Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States|Bronson Methodist Hospital, Kalamazoo, Michigan, 49007, United States|Corewell Health Children's, Royal Oak, Michigan, 48073, United States|Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota, 55404, United States|University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, 55455, United States|University of Mississippi Medical Center, Jackson, Mississippi, 39216, United States|Children's Mercy Hospitals and Clinics, Kansas City, Missouri, 64108, United States|Cardinal Glennon Children's Medical Center, Saint Louis, Missouri, 63104, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Mercy Hospital Saint Louis, Saint Louis, Missouri, 63141, United States|Children's Hospital and Medical Center of Omaha, Omaha, Nebraska, 68114, United States|University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States|University Medical Center of Southern Nevada, Las Vegas, Nevada, 89102, United States|Sunrise Hospital and Medical Center, Las Vegas, Nevada, 89109, United States|Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada, 89135, United States|Summerlin Hospital Medical Center, Las Vegas, Nevada, 89144, United States|Renown Regional Medical Center, Reno, Nevada, 89502, United States|Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, 03756, United States|Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States|Morristown Medical Center, Morristown, New Jersey, 07960, United States|Saint Peter's University Hospital, New Brunswick, New Jersey, 08901, United States|Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey, 08903, United States|Albany Medical Center, Albany, New York, 12208, United States|Montefiore Medical Center - Moses Campus, Bronx, New York, 10467, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States|NYU Langone Hospital - Long Island, Mineola, New York, 11501, United States|The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, 11040, United States|Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York, 10016, United States|NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York, 10032, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|NYP/Weill Cornell Medical Center, New York, New York, 10065, United States|University of Rochester, Rochester, New York, 14642, United States|Stony Brook University Medical Center, Stony Brook, New York, 11794, United States|State University of New York Upstate Medical University, Syracuse, New York, 13210, United States|New York Medical College, Valhalla, New York, 10595, United States|Mission Hospital, Asheville, North Carolina, 28801, United States|UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, 27599, United States|Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, 28203, United States|Novant Health Presbyterian Medical Center, Charlotte, North Carolina, 28204, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|East Carolina University, Greenville, North Carolina, 27834, United States|Wake Forest University Health Sciences, Winston-Salem, North Carolina, 27157, United States|Sanford Broadway Medical Center, Fargo, North Dakota, 58122, United States|Children's Hospital Medical Center of Akron, Akron, Ohio, 44308, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|Rainbow Babies and Childrens Hospital, Cleveland, Ohio, 44106, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|Dayton Children's Hospital, Dayton, Ohio, 45404, United States|ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio, 43606, United States|University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, United States|Legacy Emanuel Children's Hospital, Portland, Oregon, 97227, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, 18103, United States|Geisinger Medical Center, Danville, Pennsylvania, 17822, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States|Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania, 19134, United States|Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, 15224, United States|Rhode Island Hospital, Providence, Rhode Island, 02903, United States|Prisma Health Richland Hospital, Columbia, South Carolina, 29203, United States|BI-LO Charities Children's Cancer Center, Greenville, South Carolina, 29605, United States|Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, 57117-5134, United States|T C Thompson Children's Hospital, Chattanooga, Tennessee, 37403, United States|East Tennessee Childrens Hospital, Knoxville, Tennessee, 37916, United States|Saint Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States|The Children's Hospital at TriStar Centennial, Nashville, Tennessee, 37203, United States|Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, 37232, United States|Dell Children's Medical Center of Central Texas, Austin, Texas, 78723, United States|Driscoll Children's Hospital, Corpus Christi, Texas, 78411, United States|Medical City Dallas Hospital, Dallas, Texas, 75230, United States|UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, 75390, United States|El Paso Children's Hospital, El Paso, Texas, 79905, United States|Cook Children's Medical Center, Fort Worth, Texas, 76104, United States|Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, 77030, United States|M D Anderson Cancer Center, Houston, Texas, 77030, United States|Covenant Children's Hospital, Lubbock, Texas, 79410, United States|UMC Cancer Center / UMC Health System, Lubbock, Texas, 79415, United States|Children's Hospital of San Antonio, San Antonio, Texas, 78207, United States|Methodist Children's Hospital of South Texas, San Antonio, Texas, 78229, United States|Scott and White Memorial Hospital, Temple, Texas, 76508, United States|Primary Children's Hospital, Salt Lake City, Utah, 84113, United States|University of Vermont and State Agricultural College, Burlington, Vermont, 05405, United States|Inova Fairfax Hospital, Falls Church, Virginia, 22042, United States|Children's Hospital of The King's Daughters, Norfolk, Virginia, 23507, United States|Naval Medical Center - Portsmouth, Portsmouth, Virginia, 23708-2197, United States|Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, 23298, United States|Seattle Children's Hospital, Seattle, Washington, 98105, United States|Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, 99204, United States|Mary Bridge Children's Hospital and Health Center, Tacoma, Washington, 98405, United States|Madigan Army Medical Center, Tacoma, Washington, 98431, United States|West Virginia University Healthcare, Morgantown, West Virginia, 26506, United States|University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin, 53792, United States|Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, 54449, United States|Children's Hospital of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Perth Children's Hospital, Perth, Western Australia, 6009, Australia|San Jorge Children's Hospital, San Juan, 00912, Puerto Rico|University Pediatric Hospital, San Juan, 00926, Puerto Rico Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.72mL 0.34mL 0.17mL |
8.58mL 1.72mL 0.86mL |
17.15mL 3.43mL 1.72mL |
Tags: Ivosidenib | AG-120 | AG120 | AG 120 | Isocitrate Dehydrogenase | mIDH1 inhibitor | 2-HG reduction | AML treatment | IDH1 mutation | d-2-hydroxyglutarate | mutant isocitrate dehydrogenase 1 | IDH inhibitor | 1448347-49-6
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Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
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P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
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P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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