Home Cart Sign in  
Chemical Structure| 1007207-67-1 Chemical Structure| 1007207-67-1

Structure of Izorlisib
CAS No.: 1007207-67-1

Chemical Structure| 1007207-67-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

CH5132799 inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM, and is less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines.

Synonyms: CH5132799; MEN1611; PA799

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Izorlisib

CAS No. :1007207-67-1
Formula : C15H19N7O3S
M.W : 377.42
SMILES Code : NC1=NC=C(C2=C3C(N(S(=O)(C)=O)CC3)=NC(N4CCOCC4)=N2)C=N1
Synonyms :
CH5132799; MEN1611; PA799
MDL No. :MFCD22419020
InChI Key :JEGHXKRHKHPBJD-UHFFFAOYSA-N
Pubchem ID :49784945

Safety of Izorlisib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Izorlisib

PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • p110γ

    PI3Kγ, IC50:36 nM

  • p110β

    PI3Kβ, IC50:0.12 μM

  • p110α

    PI3Kα, IC50:14 nM

  • p110δ

    PI3Kδ, IC50:0.50 μM

In Vitro:

Cell Line
Concentration Treated Time Description References
Small-diameter trigeminal ganglion neurons 1 μM CH5132799, a selective inhibitor of class I PI3Ks, prevented the MC4R-mediated IA response PMC6462507

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01222546 Solid Tumors PHASE1 COMPLETED 2025-12-12 Investigator Sites, London, Le... More >>eds, United Kingdom Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.26mL

13.25mL

2.65mL

1.32mL

26.50mL

5.30mL

2.65mL

References

 

Historical Records

Categories