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Chemical Structure| 878489-28-2 Chemical Structure| 878489-28-2

Structure of JNJ 303
CAS No.: 878489-28-2

Chemical Structure| 878489-28-2

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JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).

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Product Details of JNJ 303

CAS No. :878489-28-2
Formula : C21H29ClN2O4S
M.W : 440.98
SMILES Code : ClC1=CC=C(OC(C)(C)C(N[C@@H]([C@@H](C2)C3)[C@@H]4C[C@H]2C[C@@]3(NS(=O)(C)=O)C4)=O)C=C1
MDL No. :MFCD18086905
InChI Key :OSGIRCJRKSAODN-DJASPMHUSA-N
Pubchem ID :11575823

Safety of JNJ 303

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
JNJ-303 is a specific inhibitor of the delayed rectifier Kv channel, notably blocks IKs with an IC50 value of 64 nM, underlining its high specificity and potential utility in researching conditions like diabetes, obesity, and disorders of the central nervous system[1].[2].

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.34mL

2.27mL

1.13mL

22.68mL

4.54mL

2.27mL

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