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CAS No. :	1037592-40-7
Formula :	C₂₃H₁₉Cl₂N₃O₄
M.W :	472.32
SMILES Code :	O=C(O)[C@@H](N)CC1=CC(Cl)=C(OCC2=C(OC(C3=CC=CC=C3)=N4)C4=CC(N)=C2)C(Cl)=C1
Synonyms :	KYT-0353; Nanvuranlat; JPH-203SBECD
MDL No. :	MFCD30534398
InChI Key :	XNRZJPQTMQZBCE-SFHVURJKSA-N
Pubchem ID :	24853505

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

KKU-055	30 μM	15 or 30 minutes	To investigate the effect of JPH203 on intracellular amino acid levels of LAT1 substrates in BTC cell lines, and found that JPH203 treatment significantly decreased the intracellular levels of LAT1 substrates.	PMC9650822
KKU-100	30 μM	15 or 30 minutes	To investigate the effect of JPH203 on intracellular amino acid levels of LAT1 substrates in BTC cell lines, and found that JPH203 treatment significantly decreased the intracellular levels of LAT1 substrates.	PMC9650822
KKU-213	30 μM	15 or 30 minutes	To investigate the effect of JPH203 on intracellular amino acid levels of LAT1 substrates in BTC cell lines, and found that JPH203 treatment significantly decreased the intracellular levels of LAT1 substrates.	PMC9650822
MCF7 cells	0.02 –20 μg/mL	24 hours	To evaluate the anticancer effect of JPH203 in combination with lapatinib, results showed that JPH203 significantly enhanced the anticancer effect of lapatinib.	PMC8586589
T47D cells	0.02 –20 μg/mL	24 hours	To evaluate the anticancer effect of JPH203 in combination with lapatinib, results showed that JPH203 significantly enhanced the anticancer effect of lapatinib.	PMC8586589
RAW 264.7 cells	20 μM	24 hours	To evaluate the effect of JPH203 on M1 macrophage polarization, results showed that JPH203 significantly downregulated the mRNA levels of pro-inflammatory factors (iNOS, TNF-α, and IL-1β) and upregulated the mRNA levels of anti-inflammatory factors (IL-10 and Arg-1) in M1 macrophages.	PMC11165524
Rat Cartilage Cells (RCC)	20 μM	24 hours	To evaluate the protective effect of JPH203 on chondrocytes, results showed that IgG/BRJ significantly suppressed ROS production in RCC and reduced the expression of pro-inflammatory factors, enhancing the metabolic activity of chondrocytes.	PMC11165524
Human umbilical vein endothelial cells (HUVECs)	50 μM	24 hours	JPH203 inhibited the proliferation, migration, invasion, and tube formation of HUVECs, indicating that LAT1 plays a crucial role in angiogenesis.	PMC7702703
Xenopus oocytes	1 μM	30 minutes	To evaluate the inhibitory effect of JPH203 on LAT1	PMC11828871
8505c	10 μM	48 hours	To evaluate the effect of JPH203 on thyroid cancer cell proliferation and mTORC1 activity, results showed that JPH203 significantly reduced cell proliferation and mTORC1 signaling.	PMC6150977
SW1736	10 μM	48 hours	To evaluate the effect of JPH203 on thyroid cancer cell proliferation and mTORC1 activity, results showed that JPH203 significantly reduced cell proliferation and mTORC1 signaling.	PMC6150977
K1	10 μM	48 hours	To evaluate the effect of JPH203 on thyroid cancer cell proliferation and mTORC1 activity, results showed that JPH203 significantly reduced cell proliferation and mTORC1 signaling.	PMC6150977
CCRF-CEM cells	10 μM	48 hours	To evaluate the cytotoxic effect of JPH203 on CCRF-CEM cells, results showed that JPH203 significantly reduced cell viability.	PMC5844108
MDA MB231 cells	10 μM	48 hours	To evaluate the cytotoxic effect of JPH203 on MDA MB231 cells, results showed that JPH203 had a minor cytotoxic effect on MDA MB231 cells.	PMC5844108
pancreatic cancer MIA PaCa-2 cells	3 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with cytotoxic anticancer drugs on cell growth, the results showed that JPH203 combined with all tested cytotoxic anticancer drugs significantly inhibited cell growth, especially when combined with gemcitabine.	PMC10268460
pancreatic cancer HPAC cells	6 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
pancreatic cancer PANC-1 cells	30 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
pancreatic cancer SUIT-2 cells	12 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
biliary tract cancer HuCCT1 cells	1.3 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
biliary tract cancer KKU-055 cells	0.9 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
biliary tract cancer KKU-100 cells	8 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
biliary tract cancer KKU-213 cells	7 μM	72 hours	To evaluate the inhibitory effects of JPH203 combined with gemcitabine on cell growth, the results showed that the combination significantly inhibited cell growth.	PMC10268460
LNCaP	10 μM	96 hours	To evaluate the effect of JPH203 on thyroid cancer cell proliferation and mTORC1 activity, results showed that JPH203 significantly reduced cell proliferation and mTORC1 signaling.	PMC6150977
THP1	40 μM	96 hours	To evaluate the antileukemic effect of JPH203 on THP1 cells, the results showed that JPH203 significantly reduced the survival rate of THP1 cells.	PMC10761356
NB4	40 μM	96 hours	To evaluate the antileukemic effect of JPH203 on NB4 cells, the results showed that JPH203 significantly reduced the survival rate of NB4 cells.	PMC10761356
U937	40 μM	96 hours	To evaluate the antileukemic effect of JPH203 on U937 cells, the results showed that JPH203 significantly reduced the survival rate of U937 cells.	PMC10761356
K562	40 μM	96 hours	To evaluate the antileukemic effect of JPH203 on K562 cells, the results showed that JPH203 significantly reduced the survival rate of K562 cells.	PMC10761356
786-O cells	100 µM		JPH203 significantly reduced phospho-mTOR levels in 786-O and ACHN cells but had a marginal effect on phospho-mTOR levels in 786-O: CLDN10A and ACHN: CLDN10A cells.	PMC11619122
ACHN cells	100 µM		JPH203 significantly reduced phospho-mTOR levels in 786-O and ACHN cells but had a marginal effect on phospho-mTOR levels in 786-O: CLDN10A and ACHN: CLDN10A cells.	PMC11619122

Nude mice	MCF7 tumor model	Intravenous injection	2 mg/kg	Every 2 days for 6 days	To evaluate the in vivo anticancer effect of JPH203 in combination with lapatinib, results showed that LJ@Trp-NPs significantly inhibited tumor growth.	PMC8586589
Rats	Anterior cruciate ligament transection (ACLT)-induced osteoarthritis model	Intra-articular injection	100 μL	Every 5 days for 30 days	To evaluate the therapeutic effect of IgG/BRJ in the osteoarthritis model, results showed that IgG/BRJ significantly promoted cartilage repair, reduced synovial inflammation, and increased the number of M2 macrophages.	PMC11165524
C57BL/6J mice	Matrigel plug assay	Intravenous injection	25 mg/kg/day	Once daily for 14 days	JPH203 significantly suppressed the growth of MIA PaCa-2 xenograft tumors and reduced intratumoral blood vessel density, indicating that inhibiting angiogenesis by targeting endothelial LAT1 can suppress tumor growth.	PMC7702703
Mice	BRAFV600E/PIK3CAH1047R double-mutant mouse model	Intraperitoneal injection	50 mg/kg/day	5 consecutive days/week for 45 days	To evaluate the effect of JPH203 on thyroid cancer tumor growth in vivo, results showed that JPH203 significantly inhibited tumor growth.	PMC6150977
BALB/c mice	4T1 subcutaneous fat pad tumor model	Injection	10 mg	Every two days for 28 days	To study the effect of JPH203 combined with anti-PD-1 antibody treatment on tumor progression and immune cell infiltration	PMC10507177
Mice	MLL-AF9 mouse model		40 μM	Not used	Not used	PMC10761356

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CAS No.: 1037592-40-7

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CAS No.: 1037592-40-7

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed