Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	383150-41-2
Formula :	C₁₇H₁₉Cl₂N₇O
M.W :	408.29
SMILES Code :	CC(C1=C2C(N(C)N=C2C)=NC(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)=C1)C
MDL No. :	MFCD09878275
InChI Key :	RNSLRQNDXRSASX-UHFFFAOYSA-N
Pubchem ID :	10223146

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P301+P310
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Human brain microvascular endothelial cells (hBMVEC)	0.1 μM or 1 μM	24 hours	To study the role of S1PR2 in brain endothelial cell responses to ischemic/reperfusion injury. Results showed that JTE013 inhibited TNF-α-induced MMP-9 activity.	Nat Commun. 2015 Aug 5;6:7893
Mouse brain endothelial cell line bEnd.3	1 μM	24 hours	To evaluate the role of S1PR2 in brain endothelial cell permeability and MMP-9 activation. Results showed that JTE013 significantly inhibited TNF-α-induced MMP-9 activity.	Nat Commun. 2015 Aug 5;6:7893
266-6 cells	10 µM	4 hours	Inhibited TCA-induced NF-κB activation	Cell Commun Signal. 2022 Oct 13;20(1):157
mouse large cholangiocytes (MLE)	10 μM	24 hours	inhibited TCA- and S1P-induced cell invasion	Hepatology. 2017 Jun;65(6):2005-2018
mouse large cholangiocytes (MLE)	10 μM	30 minutes	inhibited TCA- and S1P-induced AKT and ERK1/2 phosphorylation	Hepatology. 2017 Jun;65(6):2005-2018
alveolar type II cells	10 μM	14 days	To evaluate the effect of JTE-013 on the differentiation of alveolar type II cells in 3D culture. Results showed a significant reduction in the percentage of HopX+ cells in JTE-013-treated organoids.	Cell Rep. 2020 Jun 30;31(13):107828
alveolar type II cells	10 μM	3 days	To evaluate the effect of JTE-013 on the differentiation of alveolar type II cells to type I cells. Results showed a significant reduction in the percentage of Ager+ cells in JTE-013-treated cells.	Cell Rep. 2020 Jun 30;31(13):107828
HT-29 cells	10 μM	24 hours	JTE-013 effectively inhibited S1P-induced S1PR2 internalization, thereby reversing 5-FU resistance.	Acta Pharmacol Sin. 2021 Mar;42(3):460-469
HCT116 cells	10 μM	24 hours	JTE-013 effectively inhibited S1P-induced S1PR2 internalization, thereby reversing 5-FU resistance.	Acta Pharmacol Sin. 2021 Mar;42(3):460-469
RAW264.7 cells	10 µM	4 hours	Inhibited TCA-induced NF-κB activation and macrophage migration	Cell Commun Signal. 2022 Oct 13;20(1):157
bone marrow-derived dendritic cells (BMDCs)	1-30μM	24 hours	suppressed IL-4-induced CCL17 and CCL22 expression in a dose-dependent manner	Acta Pharmacol Sin. 2020 Nov;41(11):1487-1496
A10 VSMCs	1 μM	30 minutes	JTE-013, as an S1PR2 antagonist, was used to block the inhibitory effect of MYDGF on VSMC phenotypic switching via the S1PR2-Rho-ROCK-F/G-actin-MRTF-A signaling pathway. Results showed that JTE-013 pretreatment partially abolished the inhibitory effects of MYDGF on PDGF-BB-induced VSMC proliferation, migration, and dedifferentiation.	Acta Pharmacol Sin. 2024 Jan;45(1):98-111

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CAS No.: 383150-41-2

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CAS No.: 383150-41-2

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Precautionary Statements-General

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ICR mice	DDC-induced cholestatic liver fibrosis model	Intraperitoneal injection	10 mg/kg	Three times per week for 4 weeks	JTE-013 significantly attenuated liver injury and fibrogenesis in DDC-induced liver fibrosis model.	Clin Mol Hepatol. 2023 Apr;29(2):465-481
ICR mice	DDC-induced liver fibrosis model	Intraperitoneal injection	10 mg/kg	Three times per week for 4 weeks	JTE-013 significantly attenuated liver histopathological injury, collagen accumulation, and the expression of fibrogenesis-associated genes in mice fed a DDC diet	Clin Mol Hepatol. 2023 Apr;29(2):465-481
Mice	PA-induced lung injury model	Intratracheal injection	1 mg/kg	Single injection at 72 hours post-PA injury	To evaluate the effect of JTE-013 on the differentiation of alveolar type II cells to type I cells in vivo. Results showed significantly fewer Tomato+ squamous cells in JTE-013-treated lungs.	Cell Rep. 2020 Jun 30;31(13):107828
ICR mice	Acute pancreatitis model	Intraperitoneal injection	10 mg/kg	Once, 1 hour before the first caerulein injection	Alleviated pancreatic injury and inflammatory response	Cell Commun Signal. 2022 Oct 13;20(1):157
Balb/c mice	DNCB-induced atopic dermatitis model	Intraperitoneal injection	3 mg/kg	From D19 to D49, administered 30 min before each DNCB challenge	Significantly suppressed DNCB-induced atopic responses in ears and lymph nodes, reduced lymph node size, levels of inflammatory cytokines, and expression of chemokines CCL17 and CCL22	Acta Pharmacol Sin. 2020 Nov;41(11):1487-1496
Balb/c mice	OVA-induced asthma model	Intraperitoneal injection	3 mg/kg	Administered 30 min before OVA sensitization, before OVA challenge, or before both events	To evaluate the role of JTE-013 in an OVA-induced asthma model. Results showed that JTE-013 significantly inhibited eosinophil accumulation and elevated Th2 cytokine levels (IL-4, IL-5, and IL-13) in BALF, and alleviated lung inflammation and mucus production.	Br J Pharmacol. 2019 Apr;176(7):938-949
Mice	Transient middle cerebral artery occlusion model (tMCAO)	Oral gavage	30 mg/kg	Single dose administered 10 minutes after reperfusion	To evaluate the effect of S1PR2 on cerebrovascular integrity in experimental stroke. Results showed that JTE013 significantly reduced brain infarct and edema ratios and improved neurological scores.	Nat Commun. 2015 Aug 5;6:7893

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed