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CAS No. :	1380424-42-9
Formula :	C₂₄H₂₁F₆NO₇
M.W :	549.42
SMILES Code :	O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)(C4=CC=C(OCO5)C5=C4)O)CC1)OC(C(F)(F)F)C(F)(F)F
MDL No. :	MFCD22987957
InChI Key :	SXHQLPHDBLTFPM-UHFFFAOYSA-N
Pubchem ID :	71656212

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

rat cortical primary neurons	250 nM	from DIV6 to DIV12, every 48 hours	To evaluate the effect of MAGL inhibition on neuronal survival. KML29 significantly increased the risk of neuronal death in neuron-enriched cultures lacking glial cells, while neuronal survival was unaffected in mixed cultures (containing glial cells).	Biomolecules. 2020 Aug 18;10(8):1198
PL neurons	100nM	10 minutes	KML29 augmented evoked excitatory neurotransmission as evidenced by a left-shift in fEPSP I/O curve, and decreased sIPSC amplitude. KML29 also altered intrinsic properties of PL neurons including depolarization of resting membrane potential, decreased membrane time constant and decreased instantaneous frequency.	Neuropharmacology. 2020 Apr;166:107964

Sprague-Dawley rats	Ischemic injury model	Intravenous injection	1 mg/kg	Once daily for three days	To evaluate the neuroprotective effects of KML29 in an ischemic injury model. Results showed that KML29 treatment significantly improved neuronal protection in the striatum and reduced neuroinflammation.	Theranostics. 2021 Sep 13;11(19):9492-9502
C57BL/6 J mice	Chronic constriction injury (CCI) model of neuropathic pain	Intraperitoneal injection	1–40 mg/kg	Once daily for 7 days	To evaluate the analgesic effects of KML29 in combination with gabapentin. Results showed that low-dose KML29 combined with gabapentin additively attenuated mechanical allodynia and synergistically reduced cold allodynia without inducing tolerance.	Br J Pharmacol. 2017 Dec;174(23):4523-4539
Mice	Inflammatory and neuropathic pain models	Intraperitoneal injection	40 mg·kg−1	Single or repeated administration	KML29 significantly attenuated carrageenan-induced paw oedema and completely reversed carrageenan-induced mechanical allodynia. These effects underwent tolerance after repeated administration of high-dose KML29, which were accompanied by CB1 receptor desensitization. KML29 partially reversed allodynia in the sciatic nerve injury model and completely prevented diclofenac-induced gastric haemorrhages.	Br J Pharmacol. 2014 Mar;171(6):1392-407
Rats	Predator-induced fear model	Intraperitoneal injection	4 and 16 mg/kg	Single administration, 4 hours before testing	KML29 produced a dose-dependent anxiolytic-like effect in TMT-exposed rats, increasing open arm time and reducing the anxiety index.	Neuropsychopharmacology. 2020 Jul;45(8):1330-1338
Male Wistar rats	Monoiodoacetate (MIA)-induced osteoarthritis pain model	Intra-articular injection	700 μg/50μl	Single administration, observed for 240 minutes	To evaluate the effect of KML29 on MIA-induced secondary allodynia. Results showed that KML29 significantly improved the hindpaw withdrawal threshold, and this analgesic effect was blocked by CB1R and CB2R antagonists.	Arthritis Res Ther. 2020 Jan 14;22(1):9
Mice	Normotensive murine model	Topical application	1 mM	Measured at 1, 4, and 8 hours post-treatment	KML29 lowers IOP in a CB1 receptor-dependent manner	Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3287-96
Rats	Object recognition task	Bilateral intra-CA1 hippocampal injections	2 ng or 20 ng	Immediately after training, tested 1 hr later	KML29 abolished the impairing effects of stress on short-term memory, improving short-term recognition memory performance	Int J Mol Sci. 2020 Oct 3;21(19):7316
Rat	Healthy rats	In vitro	1 µM	1 hour	KML29 significantly reduced MAGL activity, by 92% in TG, 88% in cDRG, 86% in tDRG, and 93% in lDRG.	Int J Mol Sci. 2021 Jan 26;22(3):1204
Male Fischer-344 rats	Uncontrollable stress model	Intra-vmPFC and intraperitoneal injection	200ng/0.5μL/hemisphere (intra-vmPFC), 40mg/kg (i.p.)	Single administration	Intra-vmPFC administration of KML29 prior to stress prevented stress-induced anxiety, while systemic administration of KML29 exacerbated stress-induced anxiety.	Neuropharmacology. 2020 Apr;166:107964
Mice	Acute N-methyl-D-aspartate (NMDA) receptor hypofunction model	Intraperitoneal injection	1, 5, 20, 40 mg/kg	Single administration	To evaluate the impact of KML-29 on long-term memory in mice, results showed that KML-29 significantly increased the LI values for memory acquisition at the highest dose (40 mg/kg), and at the two highest doses (20 and 40 mg/kg) for memory consolidation and retrieval stages.	Int J Mol Sci. 2023 Jul 13;24(14):11400

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CAS No.: 1380424-42-9

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CAS No.: 1380424-42-9

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Precautionary Statements-General

Prevention

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	1.82mL 0.36mL 0.18mL	9.10mL 1.82mL 0.91mL	18.20mL 3.64mL 1.82mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed