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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 881375-00-4 Chemical Structure| 881375-00-4

Structure of KU-0060648
CAS No.: 881375-00-4

Chemical Structure| 881375-00-4

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KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, and with less inhibition of PI3Kγ with IC50 of 0.59 μM.

4.5 *For Research Use Only !

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Product Details of KU-0060648

CAS No. :881375-00-4
Formula : C33H34N4O4S
M.W : 582.71
SMILES Code : O=C(NC1=C(C2=CC=CC=C2S3)C3=C(C4=CC=CC5=C4OC(N6CCOCC6)=CC5=O)C=C1)CN7CCN(CC)CC7
MDL No. :MFCD17214218

Safety of KU-0060648

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P301+P310
Class:6.1
UN#:2811
Packing Group:

Related Pathways of KU-0060648

DNA
PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • p110γ

    PI3Kγ, IC50:0.59 μM

  • p110β

    PI3Kβ, IC50:0.5 nM

  • p110α

    PI3Kα, IC50:4 nM

  • p110δ

    PI3Kδ, IC50:0.1 nM

  • DNA-PK

    DNA-PK, IC50:5 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.58mL

1.72mL

0.86mL

17.16mL

3.43mL

1.72mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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