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Chemical Structure| 866021-03-6 Chemical Structure| 866021-03-6

Structure of L-745870 3HCl
CAS No.: 866021-03-6

Chemical Structure| 866021-03-6

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L-745870 trihydrochloride is a selective dopamine D4 receptor antagonist with oral activity and blood-brain barrier permeability, with a Ki of 0.43 nM. It has weaker affinity for D2 and D3 receptors and moderate affinity for 5-HT2 receptors, σ sites, and α-adrenergic receptors.

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Product Details of L-745870 3HCl

CAS No. :866021-03-6
Formula : C18H22Cl4N4
M.W : 436.21
SMILES Code : ClC1=CC=C(N2CCN(CC3=CNC4=NC=CC=C43)CC2)C=C1.[H]Cl.[H]Cl.[H]Cl
MDL No. :MFCD01074795
InChI Key :KJSOYZLYCFYXFC-UHFFFAOYSA-N
Pubchem ID :49759035

Safety of L-745870 3HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of L-745870 3HCl

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Isoform Comparison

Biological Activity

Description
L-745870 trihydrochloride, a potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist, has a Ki of 0.43 nM. This compound demonstrates lower affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors[1][2][3].

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