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Chemical Structure| 32854-09-4 Chemical Structure| 32854-09-4
Chemical Structure| 32854-09-4

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Dimethyl 3,3'-disulfanediyl(2R,2'R)-bis(2-aminopropanoate) dihydrochloride is a cysteine derivative, commonly used in biochemical research and drug synthesis.

Synonyms: Dimethyl 3,3'-disulfanediyl(2R,2'R)-bis(2-aminopropanoate) dihydrochloride

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Product Details of L-Cystine dimethyl ester 2HCl

CAS No. :32854-09-4
Formula : C8H18Cl2N2O4S2
M.W : 341.28
SMILES Code : N[C@H](CSSC[C@H](C(OC)=O)N)C(OC)=O.[H]Cl.[H]Cl
Synonyms :
Dimethyl 3,3'-disulfanediyl(2R,2'R)-bis(2-aminopropanoate) dihydrochloride
MDL No. :MFCD00012490

Safety of L-Cystine dimethyl ester 2HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of L-Cystine dimethyl ester 2HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 32854-09-4 ]

[ 32854-09-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32854-09-4 ]
  • [ 141871-02-5 ]
  • C34H46N4O10S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
35% With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane;Inert atmosphere; A solution of 7a (177 mg, 1.17 mmol), pyBOP (582 mg,1.17 mmol), and Et3N (179 mL, 1.28 mmol) in DCM (5 mL) was stirred for 15 min to which was added L-cystine dimethyl ester dihydrochloride (200 mg, 0.586 mmol). The mixture was stirred overnight under an inert atmosphere. The mixture was concentrated under vacuum, and taken up in EtOAc (10 mL). Theo rganic layer was was hed with H2O (10mL), NaHCO3 (10 mL), brine (10 mL), dried over MgSO4, filtered, and concentratedunder vacuum. The product was purified using column chromatography with EtOAc-petroleum eluent, which afforded the title compound as awhite amorphous solid (300 mg, 35% yield). H (400MHz, CDCl3) 7.70 (d,J7.6, 1H), 7.45 (td,J7.7, 1.6,1H), 7.40 -7.07 (m, 4H), 5.02 (s, 1H), 3.76 (s, 3H), 3.29 (m,2H), 3.19 (s, 3H), 1.33 (s, 9H). C (100MHz, CDCl3) 170.5, 141.4,131.7, 129.5, 128.1, 127.3, 80.8, 52.8, 51.9, 40.5, 29.7, 28.2. HRMS (ESI) m/z757.2507; calcd for C34H46N4O10S2Na [MNa] 757.2548. nmax/cm13337, 2960, 1743, 1664, 1152, 730
 

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