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Chemical Structure| 343307-76-6 Chemical Structure| 343307-76-6

Structure of L48H37
CAS No.: 343307-76-6

Chemical Structure| 343307-76-6

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L48H37 is a chemically stable curcumin analog and an effective inhibitor of myeloid differentiation protein 2 (MD2) that inhibits the LPS-TLR4/MD2-mediated signaling pathway, suitable for research on sepsis and lung injury.

4.5 *For Research Use Only !

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Product Details of L48H37

CAS No. :343307-76-6
Formula : C27H33NO7
M.W : 483.55
SMILES Code : O=C1/C(CN(CC)C/C1=C\C2=CC(OC)=C(OC)C(OC)=C2)=C/C3=CC(OC)=C(OC)C(OC)=C3
MDL No. :MFCD08560158

Safety of L48H37

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of L48H37

pyroptosis
TLR

Isoform Comparison

Biological Activity

Description
L48H37 is a Curcumin analogue exhibiting enhanced chemical stability. It acts as a potent and selective inhibitor of myeloid differentiation protein 2 (MD2), effectively disrupting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is employed in research for the treatment of sepsis or lung injury[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.34mL

2.07mL

1.03mL

20.68mL

4.14mL

2.07mL

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