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Chemical Structure| 203120-46-1 Chemical Structure| 203120-46-1

Structure of Laninamivir octanoate
CAS No.: 203120-46-1

Chemical Structure| 203120-46-1

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Laninamivir octanoate is a neuraminidase inhibitor that exhibits clinical efficacy for both treatment and prophylaxis of influenza virus infection, resulting from hydrolytic bioactivation into its pharmacologically active metabolite laninamivir in the pulmonary tissue.

Synonyms: CS-8958; R-118958; LANI

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Product Details of Laninamivir octanoate

CAS No. :203120-46-1
Formula : C21H36N4O8
M.W : 472.53
SMILES Code : O=C(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@H]([C@H](OC)[C@H](O)COC(CCCCCCC)=O)O1)O
Synonyms :
CS-8958; R-118958; LANI
MDL No. :MFCD28138619

Safety of Laninamivir octanoate

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice Immunocompromised nude mouse model Intranasal administration 1.5 mg/kg Once a week for 5 or 28 days To evaluate the effect of Laninamivir alone or in combination with Favipiravir on survival time and viral titers in immunocompromised nude mice. Results showed that combination therapy prolonged survival time but did not completely clear the virus. J Infect Dis. 2018 Mar 5;217(6):887-896

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.58mL

2.12mL

1.06mL

21.16mL

4.23mL

2.12mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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