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Chemical Structure| 1403947-26-1 Chemical Structure| 1403947-26-1

Structure of LAS191954
CAS No.: 1403947-26-1

Chemical Structure| 1403947-26-1

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LAS191954 is a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases. LAS191954 showed PI3Kdelta IC50 = 2.6 nM; M-CSF p-Akt IC50 = 7.8 nM; % Metabolism (R/H) = 20/16; PK i.v. t1/2 (R/D) = 3.1 h/10.2h. LAS191954 showed efficacy at significantly lower doses than Idelalisib. LAS191954 showed a potency on the target of 2.6 nM, with the highest selectivity versus PI3Kα (8.2 μM) and the lowest versus PI3Kγ and PI3Kβ (72 and 94 nM, respectively).

Synonyms: LAS191954

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Product Details of LAS191954

CAS No. :1403947-26-1
Formula : C20H15N9O
M.W : 397.39
SMILES Code : N#CC1=C(C2=O)N(N=C(N2C3=CC=CC=C3)[C@H](C)NC4=NC=NC(N)=C4C#N)C=C1
Synonyms :
LAS191954
MDL No. :MFCD28502110

Safety of LAS191954

Related Pathways of LAS191954

PI3K-AKT

Isoform Comparison

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1 mM

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2.52mL

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12.58mL

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1.26mL

25.16mL

5.03mL

2.52mL

 

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