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Chemical Structure| 434283-16-6 Chemical Structure| 434283-16-6

Structure of Lecozotan
CAS No.: 434283-16-6

Chemical Structure| 434283-16-6

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Lecozotan is a potent and selective 5-HT(1A) receptor antagonist. It significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. It produced a significant improvement in task performance efficiency at an optimal dose (1 mg/kg p.o.) in aged rhesus monkeys.

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Product Details of Lecozotan

CAS No. :434283-16-6
Formula : C28H29N5O3
M.W : 483.56
SMILES Code : O=C(N(C[C@H](N1CCN(C2=C3OCCOC3=CC=C2)CC1)C)C4=NC=CC=C4)C5=CC=C(C#N)C=C5
MDL No. :MFCD22124707

Safety of Lecozotan

Related Pathways of Lecozotan

GPCR

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00538889 Healthy Phase 1 Completed - United Kingdom ... More >> Manchester, United Kingdom Less <<
NCT00499642 Alzheimer Disease ... More >> Healthy Less << Phase 1 Completed - France ... More >> Rennes, France, 35000 Rueil-Malmaison, France, 92502 Less <<
NCT00151398 Alzheimer Disease Phase 2 Completed - -
NCT00277810 Alzheimer Disease Phase 2 Phase 3 Completed - -
NCT00563732 Alzheimer Disease Phase 1 Completed - -
NCT00494962 Alzheimer Disease Phase 1 Completed - Germany ... More >> Neuss, Germany, 41460 Less <<
NCT00366483 Alzheimer Disease Phase 1 Completed - France ... More >> Paris, France Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.34mL

2.07mL

1.03mL

20.68mL

4.14mL

2.07mL

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