Structure of Lestaurtinib
CAS No.: 111358-88-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Lestaurtinib is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic derivative of the indolocarbazole K252a was investigated by Cephalon as a treatment for various types of cancer.
Synonyms: CEP-701; KT-5555; SP 924. Lestaurtinib.
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CAS No. : | 111358-88-4 |
Formula : | C26H21N3O4 |
M.W : | 439.46 |
SMILES Code : | O=C1NCC(C2=C3N([C@]4(C)[C@](CO)(O)C[C@@]5([H])O4)C6=CC=CC=C62)=C1C7=C3N5C8=CC=CC=C78 |
Synonyms : |
CEP-701; KT-5555; SP 924. Lestaurtinib.
|
MDL No. : | MFCD09840836 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02596347 | - | Unknown | - | United States, Colorado ... More >> National Jewish Health Recruiting Denver, Colorado, United States, 80206 Contact: Gina M Atnes, BA 303-398-1679 mondellog@njhealth.org Principal Investigator: Li Li, MD Less << | |
NCT00081601 | Prostate Cancer | Phase 2 | Completed | - | United States, Maryland ... More >> Johns Hopkins Baltimore, Maryland, United States, 21287 Less << |
NCT00030186 | Leukemia, Myeloid | Phase 2 | Completed | - | - |
NCT01150669 | - | Completed | - | United States, California ... More >> Children's Oncology Group Monrovia, California, United States, 91006-3776 Less << | |
NCT00236119 | Psoriasis | Phase 2 | Completed | - | United States, North Carolina ... More >> Wake Forest University Winston-Salem, North Carolina, United States, 27157 United States, Texas Texas Dermatology Rsch Inst Dallas, Texas, United States, 75230 United States, Virginia Viginia Clinical Research Norfolk, Virginia, United States, 23507 Less << |
NCT00557193 | Acute Lymphoblastic Leukemia ... More >> Acute Undifferentiated Leukemia Childhood T Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Less << | Phase 3 | Completed | - | - |
NCT00242827 | Myeloma | Phase 2 | Terminated | - | United States, Georgia ... More >> Emory University Winship Cancer Institute Atlanta, Georgia, United States, 30302 United States, Indiana Indiana Univeristy Cancer Research Center Indianapolis, Indiana, United States, 46202 United States, New Jersey The Cancer Center Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York New York Presbyterian Hospital New York, New York, United States, 10021 United States, Pennsylvania Abramson Cancer Center Of University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
NCT02428543 | Acute Myeloid Lukemia | Phase 1 Phase 2 | Recruiting | September 2020 | France ... More >> Dr Abdelaziz CHAIB Recruiting Aix-en-Provence, France, 13600 Contact: Abdelaziz CHAIB achaib@ch-aix.fr Principal Investigator: Abdelaziz CHAIB Chu Amiens Recruiting Amiens, France, 80054 Contact: MAROLLEAU Jean Pierre Principal Investigator: MAROLLEAU Jean Pierre CHU d'Angers Recruiting Angers, France, 49033 Contact: Martine GARDEMBAS Magardembas@chu-angers.fr Principal Investigator: Martine GARDEMBAS Hôpital VICTOR DUPOUY Recruiting Argenteuil, France, 95107 Contact: AL JIJAKLI Ahmad ahmad.aljijakli@ch-argenteuil.fr Principal Investigator: AL JIJAKLI Ahmad Dr Edouard RANDIAMALALA Recruiting Bayonne, France, 64100 Contact: Edouard RANDIAMALALA erandiamalala@ch-cotebasque.fr Principal Investigator: Edouard RANDIAMALALA CHU de Besançon Recruiting Besançon, France, 25030 Contact: Fabrice LAROSA flarosa@chu-besançon.fr Principal Investigator: Fabrice LAROSA Dr Thorsten BRAUN Recruiting Bobigny, France, 93000 Contact: Thorsten BRAUN thorsten.braun@aphp.fr Principal Investigator: Thorsten BRAUN CHU Boulogne Sur Mer Recruiting Boulogne Sur Mer cedex, France, 62321 Contact: CHOUFI Bachra b.choufi@ch-boulogne.fr Principal Investigator: CHOUFI Bachra Chr Clemenceau Recruiting Caen Cedex, France, 14033 Contact: REMAN Oumédaly reman-o@chu-caen.fr Principal Investigator: REMAN Oumédaly Hôpital d'Instruction des Armées PERCY Recruiting Clamart, France, 92141 Contact: Jean Valère MALFUSSON jvmalf@free.fr Principal Investigator: Jean Valère MALFUSSON Dr Stéphanie HAÏAT Recruiting Corbeil-essonnes, France, 91100 Contact: Stéphanie HAÏAT Principal Investigator: Stéphanie HAÏAT Hôpital Henri Mondor Recruiting Créteil, France, 94010 Contact: PAUTAS Cécile cecile.pautas@hmn.aphp.fr Principal Investigator: PAUTAS Cécile CHU de Dijon Not yet recruiting Dijon, France, 21079 Contact: CAILLOT Denis denis.caillot@chu-dijon.fr Principal Investigator: CAILLOT Denis Centre hospitalier de Versailles Recruiting Le Chesnay cedex, France, 78157 Contact: Rousselot Philippe 003339638622 phrousselot@ch-versailles.fr Principal Investigator: Rousselot Philippe Hôpital Claude Huriez Recruiting Lille cedex, France, 59037 Contact: QUESNEL Bruno bquesnel@chru-lille.fr Principal Investigator: QUESNEL Bruno CHRU Dupuytren Not yet recruiting Limoges cedex, France, 87042 Contact: TURLURE Pascal pascal.turlure@chu-limoges.fr Principal Investigator: TURLURE Pascal Hôpital Edouard Herriot Recruiting Lyon cedex 03, France, 69437 Contact: THOMAS Xavier xavier.thomas@chu-lyon.fr Principal Investigator: THOMAS Xavier Dr Regis COSTELLO Recruiting Marseille, France, 13000 Contact: Regis COSTELLO regis.costello@ap-hm.fr Principal Investigator: Regis COSTELLO Centre Hospitalier de Meaux Recruiting Meaux, France, 77104 Contact: FRAYFER Jamilé j-frayfer@ch-meaux.fr Principal Investigator: FRAYFER Jamilé Dr Mario OJEDA-URIBE Recruiting Mulhouse, France, 68000 Contact: Mario OJEDA-URIBE ojedam@ch-mulhouse.fr Principal Investigator: Mario OJEDA-URIBE Dr Jacques DELAUNAY Recruiting Nantes, France, 44000 Contact: Jacques DELAUNAY jacques.delaunay@chu-nantes.fr Principal Investigator: Jacques DELAUNAY CHU Nice, Hôpital Archet 1 Recruiting Nice cedex 3, France, 06202 Contact: MANNONE Lionel mannone.l@chu-nice.fr Principal Investigator: MANNONE Lionel CHU de Nîmes Recruiting Nîmes, France, 30029 Contact: Eric JOURDAN eric.jourdan@chu-nimes.fr Principal Investigator: Eric Jourdan Hôpital Saint Antoine Recruiting Paris cedex 12, France, 75751 Contact: ISNARD Françoise francoise.isnard@sat.aphp.fr Principal Investigator: ISNARD Françoise Hôpital Necker Enfants Malades Recruiting Paris cedex 15, France, 75743 Contact: SUAREZ Felipe felipe.suarez@nck.aphp.fr Principal Investigator: SUAREZ Felipe Hôpital Saint Louis Recruiting Paris, France, 75010 Contact: RAFFOUX Emmanuel emmanuel.raffoux@sls.ap-hop-paris.fr Principal Investigator: RAFFOUX Emmanuel Hôpital La Pitié Salpêtrière Recruiting Paris, France, 75013 Contact: UZUNOV Madalina madalina.uzunov@psl.aphp.fr Principal Investigator: UZUNOV Madalina Dr Laurence SANHES Suspended Perpignan, France, 66000 Dr Arnaud PIGNEUX Recruiting Pessac, France, 33604 Contact: Arnaud PIGNEUX arnaud.pigneux@chu-bordeaux.fr Principal Investigator: Arnaud PIGNEUX Centre Hospitalier René Dubos Recruiting Pontoise Cedex, France, 95303 Contact: VAIDA Iona Dana ioana.vaida@ch-pontoise.fr Principal Investigator: VAIDA Iona Dana Marc BERNARD Recruiting Rennes, France, 35000 Contact: Marc BERNARD marc.bernard@chu-rennes.fr Principal Investigator: Marc BERNARD Dr Emilie LEMASLE Recruiting Rouen, France, 76000 Contact: Emilie LEMASLE emilie.lemasle@chb.unicancer.fr Principal Investigator: Emilie LEMASLE Centre Hospitalier René Huguenin Suspended Saint Cloud, France, 92210 Institut de Cancérologie de la Loire Recruiting Saint-Priest-en-Jarez, France, 42270 Contact: Emmanuelle TAVERNIER-TARDY emmanuelle.tavernier@icloire.fr Principal Investigator: Emmanuelle TAVERNIER-TARDY Dr Réda GARIDI Recruiting Saint-Quentin, France, 02100 Contact: Réda GARIDI Principal Investigator: Réda GARIDI Dr Christian RECHER Recruiting Toulouse, France, 31000 Contact: Christian RECHER Principal Investigator: Christian RECHER Centre Hospitalier de Valenciennes Recruiting Valenciennes, France, 59322 Contact: FERNANDES José fernandes-j@ch-valenciennes.fr Principal Investigator: FERNANDES José Less << |
NCT00586651 | Polycythemia Vera ... More >> Essential Thrombocytosis Less << | Phase 2 | Completed | - | United States, Maryland ... More >> Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, New York NY Presbyterian-Cornell New York City, New York, United States, 10021 Mount Sinai School of Medicine New York, New York, United States, 10128 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
NCT00079482 | Acute Myeloid Leukemia | Phase 2 | Completed | - | - |
NCT00494585 | Leukemia Myel... More >>ofibrosis Less << | Phase 2 | Completed | - | United States, Texas ... More >> The University of Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00084422 | Neuroblastoma | Phase 1 | Completed | - | United States, California ... More >> Childrens Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucille Salter Packer Children's Hospital, Stanford University Palo Alto, California, United States, 94305 UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94143 United States, Georgia AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus Atlanta, Georgia, United States, 30322 United States, Illinois University of Chicago Comer Children's Hospital Chicago, Illinois, United States, 60637 United States, Massachusetts Children's Hospital Boston Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, New York Morgan Stanley Children's Hospital of New York-Presbyterian New York, New York, United States, 10032 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104-4318 United States, Washington Children's Hospital and Regional Medical Center - Seattle Seattle, Washington, United States, 98105 Canada, Ontario Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Less << |
NCT00494585 | - | Completed | - | - | |
NCT00469859 | Leukemia | Phase 1 Phase 2 | Completed | - | - |
NCT00469859 | - | Completed | - | - | |
NCT00557193 | - | Completed | - | - | |
NCT00668421 | Myelofibrosis ... More >> Essential Thrombocythemia Polycythemia Vera Less << | Phase 1 Phase 2 | Unknown | January 2015 | United States, California ... More >> Palo Alto Medical Facilities Palo Alto, California, United States, 94301 United States, District of Columbia Georgetown University Medicine Center Washington, District of Columbia, United States, 20007 United States, Maryland University of Maryland Marlene and Stewart Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, New York Weill Cornell Ithaca, New York, United States, 14851 Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19107 United States, Utah University of Utah Salt Lake City, Utah, United States, 84102 Less << |
Tags: Lestaurtinib | CEP-701 | JAK | Apoptosis Inducer | STAT | FLT3 | Trk Receptor | Apoptosis | Apoptosis | Cell Apoptosis/Death Detection | Epigenetics | Protein Tyrosine Kinase/RTK | Angiogenesis | Stem Cells | JAK-STAT-Signaling | Parkinson'S Disease and Alzheimer'S Disease | Tumor Development and Microenvironment Evolution | Exosome | Cancer Stem Cells | PPAR Signaling Pathway | Neuronal Signaling | 111358-88-4
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