Structure of Linagliptin
CAS No.: 668270-12-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Linagliptin, a purine and quinazoline derivative, can inhibit DPP-4 with IC50 of 1 nM. It functions as an incretin and is used as a hypoglycemic agents in the treatment of type 2 diabetes mellitus.
Synonyms: BI 1356; GSK2118436
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 668270-12-0 |
Formula : | C25H28N8O2 |
M.W : | 472.54 |
SMILES Code : | CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C |
Synonyms : |
BI 1356; GSK2118436
|
MDL No. : | MFCD14635356 |
InChI Key : | LTXREWYXXSTFRX-QGZVFWFLSA-N |
Pubchem ID : | 10096344 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
In Vitro:
Concentration | Treated Time | Description | References |
human cardiomyocytes | 100 mM | 30 minutes | To evaluate the effect of Linagliptin on cardiomyocyte passive stiffness, results showed that Linagliptin significantly reduced cardiomyocyte passive stiffness. | PMC7812306 |
human cardiomyocytes | 100 mM | 2 hours | To evaluate the effect of Linagliptin on DPP-4-mediated titin cleavage, results showed that Linagliptin completely prevented DPP-4-induced titin cleavage. | PMC7812306 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Swiss mice | Morphine dependence model | Intraperitoneal injection | 10 and 20 mg/kg | Once daily for 8 consecutive days | Linagliptin significantly reduced morphine withdrawal symptoms (jumping behavior) in mice and alleviated depressive and anxiety behaviors during short-term and long-term morphine withdrawal. | PMC9028142 |
ZSF1 rats | MetS-induced cardiac disease model | Oral | 83 mg/kg | once daily for 4 weeks | To evaluate the effect of Linagliptin on left ventricular stiffness, results showed that Linagliptin significantly improved left ventricular relaxation, reduced cardiomyocyte passive stiffness, and decreased cardiac fibrosis. | PMC7812306 |
db/db mice | type 2 diabetes model | Oral | 10 mg/kg | Once daily for 8 weeks | To assess the effect of Linagliptin on glomerular autophagy in a model of type 2 diabetes, the results showed that Linagliptin alone or in combination with Empagliflozin enhanced glomerular autophagy, mitigated glomerular sclerosis and podocyte injury, and slowed the growth of albuminuria. | PMC7215949 |
C57BL6/ApoE-/- mice | High fat diet-induced metabolic disease model | Oral gavage | 10 mg/kg | Once daily for 28 days | To validate the regulatory effect of DPP4 inhibitor on insulin-induced vascular oxidative stress in vivo, results showed DPP4i pretreatment reversed the effects of insulin on vascular oxidative stress | PMC7212010 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02183376 | Hepatic Insufficiency | PHASE1 | COMPLETED | - | - |
NCT01778049 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT02183532 | Healthy | Phase 1 | Completed | - | - |
NCT01778049 | - | Completed | - | - | |
NCT00819091 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01703286 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | Germany ... More >> 1218.105.001 Boehringer Ingelheim Investigational Site Neuss, Germany Less << |
NCT00819091 | - | Completed | - | - | |
NCT02173639 | Healthy | Phase 1 | Completed | - | - |
NCT01703286 | - | Completed | - | - | |
NCT01087502 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT02173652 | Healthy | Phase 1 | Completed | - | - |
NCT01087502 | - | Completed | - | - | |
NCT01734785 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01708902 | - | Completed | - | - | |
NCT02821910 | Healthy | Phase 1 | Completed | - | Germany ... More >> Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT02183428 | Healthy | Phase 1 | Completed | - | - |
NCT01708902 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01215097 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | China ... More >> 1218.65.86007 Boehringer Ingelheim Investigational Site Beijing, China 1218.65.86011 Boehringer Ingelheim Investigational Site Chongqing, China 1218.65.86008 Boehringer Ingelheim Investigational Site Dalian, China 1218.65.86010 Boehringer Ingelheim Investigational Site Fuzhou, China 1218.65.86014 Boehringer Ingelheim Investigational Site Hangzhou, China 1218.65.86005 Boehringer Ingelheim Investigational Site Hefei, China 1218.65.86006 Boehringer Ingelheim Investigational Site Hefei, China 1218.65.86012 Boehringer Ingelheim Investigational Site Nanjing, China 1218.65.86001 Boehringer Ingelheim Investigational Site Shanghai, China 1218.65.86002 Boehringer Ingelheim Investigational Site Shanghai, China 1218.65.86003 Boehringer Ingelheim Investigational Site Shanghai, China 1218.65.86004 Boehringer Ingelheim Investigational Site Suzhou, China 1218.65.86015 Boehringer Ingelheim Investigational Site Wenzhou, China 1218.65.86009 Boehringer Ingelheim Investigational Site Wuhan, China 1218.65.86013 Boehringer Ingelheim Investigational Site Yangzhou, China Malaysia 1218.65.60002 Boehringer Ingelheim Investigational Site Johor Bahru,, Malaysia 1218.65.60001 Boehringer Ingelheim Investigational Site Kelantan, Malaysia Philippines 1218.65.63001 Boehringer Ingelheim Investigational Site Marikina, Philippines 1218.65.63002 Boehringer Ingelheim Investigational Site San Juan, Philippines Less << |
NCT01215097 | - | Completed | - | - | |
NCT01734785 | - | Completed | - | - | |
NCT00800683 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00621140 | - | Completed | - | - | |
NCT02183493 | Healthy | PHASE1 | COMPLETED | - | - |
NCT02191228 | Renal Insufficiency | Phase 1 | Completed | - | - |
NCT00800683 | - | Completed | - | - | |
NCT02221414 | Healthy | Phase 1 | Completed | - | - |
NCT02183441 | Healthy | Phase 1 | Completed | - | - |
NCT00621140 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT02489968 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT03433248 | Type2 Diabetes | Phase 4 | Recruiting | December 1, 2020 | Netherlands ... More >> VU University Medical Center Recruiting Amsterdam, Noord-Holland, Netherlands, 1081HV Contact: Michaël JB van Baar, MD +31 20 444 4709 m.vanbaar@vumc.nl Contact: Daniël H van Raalte, MD PhD +31 20 444 0534 d.vanraalte@vumc.nl Principal Investigator: Mark HH Kramer, MD PhD Principal Investigator: Daniël H van Raalte, MD PhD Less << |
NCT02221401 | Healthy | Phase 1 | Completed | - | - |
NCT02489968 | - | Completed | - | - | |
NCT01438814 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT01947153 | - | Completed | - | - | |
NCT02220647 | Healthy | Phase 1 | Completed | - | - |
NCT01897532 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT01438814 | - | Completed | - | - | |
NCT02897349 | Diabetes Mellitus, Type 2 | Phase 3 | Active, not recruiting | January 30, 2019 | China ... More >> China-Japan Friendship Hospital Beijing, China, 100029 Beijing Tongren Hospital Beijing, China, 100730 The General Hospital of Chinese People's Armed Police Forces Beijing, China, 100854 First Hospital of Jilin University Changchun, China, 130021 Fuzhou General Hospital of Nanjing Militray Command Fuzhou, China, 350025 Third Affiliated Hospital of Guangzhou Medical University Guangzhou, China, 510150 The Affiliated Hospital of Guizhou Medical University Guiyang, China, 550004 Hangzhou Second People's Hospital Hangzhou, China, 310015 General Hospital of Jinan Military Area Jinan, China, 250000 Nanjing First Hospital Nanjing, China, 210006 The affiliated hospital of medicalcollege qingdao university Qingdao, China, 266005 Centre Hospital of Putuo District, Shanghai Shanghai, China, 200062 Shanghai Tenth People's Hospital Shanghai, China, 200072 Yangpu Hospital, Tongji University Shanghai, China, 200090 Second Hospital Affiliated to Shantou Medical University Shantou, China, 515041 Shengjing Hospital of China Medical University Shengyang, China, 110072 Siping Central People's Hospital Siping, China, 136000 The First Affiliated Hospital of Soochow University Suzhou, China, 215006 Nankai University Affiliated Hospital Tianjin, China, 300000 The 2nd Hospital of Tianjin Medical University Tianjin, China, 300000 Tianjin Medical University General Hospital Tianjin, China, 30052 Renmin Hospital of Wuhan University Wuhan, China, 430060 First Affiliated Hospital of Xiamen University Xiamen, China, 361003 the first people hospital of Yue Yang Yueyang, China, 414000 Affiliated Hospital of Jiangsu University Zhenjiang, China, 212013 Less << |
NCT01947153 | Healthy | Phase 1 | Completed | - | Russian Federation ... More >> 1288.21.1 Boehringer Ingelheim Investigational Site St. Petersburg, Russian Federation Less << |
NCT02172222 | Healthy | Phase 1 | Completed | - | - |
NCT01194830 | - | Completed | - | - | |
NCT01194830 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01903356 | - | Completed | - | Korea, Republic of ... More >> One or multiple Investigational sites, Korea, Republic of Less << | |
NCT00602472 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT02183636 | Healthy | Phase 1 | Completed | - | - |
NCT01342484 | - | Completed | - | - | |
NCT00602472 | - | Completed | - | - | |
NCT01969084 | Type II Diabetes Mellitus | Phase 4 | Completed | - | United States, Massachusetts ... More >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Less << |
NCT01969084 | - | Completed | - | - | |
NCT01512979 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT01888796 | Diabetes Mellitus Type 2 (T2DM... More >>) Left Ventricular Diastolic Dysfunction Less << | Phase 3 | Terminated(bad recruitment of ... More >>suitable participants, just 8 patients in one year) Less << | - | Germany ... More >> Department of Internal Medicine I, University Hospital Aachen, Germany, 52074 Less << |
NCT01342484 | Diabetes Mellitus, Type 2 | Phase 2 | Completed | - | United States, Texas ... More >> 1218.56.01006 Boehringer Ingelheim Investigational Site San Antonio, Texas, United States United States, Virginia 1218.56.01004 Boehringer Ingelheim Investigational Site Norfolk, Virginia, United States Canada, Quebec 1218.56.11001 Boehringer Ingelheim Investigational Site Montreal, Quebec, Canada France 1218.56.33003 Boehringer Ingelheim Investigational Site Fort de France cedex, France 1218.56.33006 Boehringer Ingelheim Investigational Site Rouen, France Guatemala 1218.56.50202 Boehringer Ingelheim Investigational Site Guatemala, Guatemala 1218.56.50203 Boehringer Ingelheim Investigational Site Guatemala, Guatemala Italy 1218.56.39005 Boehringer Ingelheim Investigational Site Firenze, Italy Korea, Republic of 1218.56.82005 Boehringer Ingelheim Investigational Site Busan, Korea, Republic of 1218.56.82001 Boehringer Ingelheim Investigational Site Seoul, Korea, Republic of 1218.56.82002 Boehringer Ingelheim Investigational Site Seoul, Korea, Republic of 1218.56.82003 Boehringer Ingelheim Investigational Site Suwon, Korea, Republic of Mexico 1218.56.52008 Boehringer Ingelheim Investigational Site Chihuahua, Mexico 1218.56.52002 Boehringer Ingelheim Investigational Site Guadalajara, Mexico 1218.56.52001 Boehringer Ingelheim Investigational Site León, Mexico 1218.56.52003 Boehringer Ingelheim Investigational Site Monterrey, Mexico 1218.56.52004 Boehringer Ingelheim Investigational Site Oaxaca, Mexico Poland 1218.56.48002 Boehringer Ingelheim Investigational Site Gdansk, Poland 1218.56.48001 Boehringer Ingelheim Investigational Site Gliwice, Poland 1218.56.48004 Boehringer Ingelheim Investigational Site Warszawa, Poland 1218.56.48003 Boehringer Ingelheim Investigational Site Wroclaw, Poland Russian Federation 1218.56.70001 Boehringer Ingelheim Investigational Site Moscow, Russian Federation 1218.56.70003 Boehringer Ingelheim Investigational Site Saratov, Russian Federation 1218.56.70004 Boehringer Ingelheim Investigational Site Ufa, Russian Federation 1218.56.70006 Boehringer Ingelheim Investigational Site Yekaterinburg, Russian Federation Less << |
NCT01512979 | - | Completed | - | - | |
NCT01581931 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1288.20.1 Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT03259490 | Healthy | Phase 1 | Completed | - | Germany ... More >> Humanpharmakologisches Zentrum Biberach Biberach, Germany, 88397 Less << |
NCT01581931 | - | Completed | - | - | |
NCT01012037 | Diabetes Mellitus, Type 2 | Phase 2 | Completed | - | - |
NCT01243424 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01012037 | - | Completed | - | - | |
NCT01276327 | - | Completed | - | - | |
NCT01792518 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01792518 | - | Completed | - | - | |
NCT00915772 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00601250 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00601250 | - | Completed | - | - | |
NCT03642184 | New Onset Diabetes After Trans... More >>plant Kidney Transplant; Complications Less << | Phase 4 | Recruiting | December 31, 2020 | China, Shanghai ... More >> Department of nephrology, endocrinology and kidney transplantation , Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine Recruiting Shanghai, Shanghai, China, 200127 Contact: Shan Mou, Dr. +8613918221242 shan_mou@126.com Less << |
NCT03629054 | Healthy | Phase 1 | Completed | - | Germany ... More >> Humanpharmakologisches Zentrum Biberach Biberach, Germany, 88397 Less << |
NCT00915772 | - | Completed | - | - | |
NCT01383356 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | Canada, Ontario ... More >> 1288.19.1 Boehringer Ingelheim Investigational Site Toronto, Ontario, Canada Less << |
NCT01383356 | - | Completed | - | - | |
NCT01276327 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1264.14.1 Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT01547104 | Diabetes Mellitus Type 2 | Phase 4 | Unknown | October 2012 | Germany ... More >> ikfe GmbH Recruiting Mainz, Rhineland-Palatinate, Germany, 55116 Contact: Thomas Forst, MD, PhD + 49 6131 57636 ext 16 ThomasF@ikfe.de Contact: Daniela Sachsenheimer, MD + 49 6131 57636 ext 46 DanielaS@ikfe.de Sub-Investigator: Daniela Sachsenheimer, MD Sub-Investigator: Stephanie Helleberg, MD Sub-Investigator: Stefan Diessel Sub-Investigator: Michael Mitry, MD Less << |
NCT00954447 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01845077 | Healthy | Phase 1 | Completed | - | United States, Texas ... More >> 1288.8.1 Boehringer Ingelheim Investigational Site Austin, Texas, United States Less << |
NCT01707147 | - | Completed | - | Korea, Republic of ... More >> Multiple Locations, Korea, Republic of Less << | |
NCT01189201 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1275.3.1 Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT01189201 | - | Completed | - | - | |
NCT00996658 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00996658 | - | Completed | - | - | |
NCT02453555 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | Japan ... More >> 1275.19.81519 Boehringer Ingelheim Investigational Site Aichi, Nagoya, Japan 1275.19.81536 Boehringer Ingelheim Investigational Site Chiba, Kashiwa, Japan 1275.19.81530 Boehringer Ingelheim Investigational Site Fukuoka, Fukuoka, Japan 1275.19.81529 Boehringer Ingelheim Investigational Site Fukuoka, Itoshima, Japan 1275.19.81531 Boehringer Ingelheim Investigational Site Fukuoka, Kurume, Japan 1275.19.81504 Boehringer Ingelheim Investigational Site Fukushima, Koriyama, Japan 1275.19.81528 Boehringer Ingelheim Investigational Site Hiroshima, Hiroshima, Japan 1275.19.81501 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81502 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81503 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81532 Boehringer Ingelheim Investigational Site Hokkaido, Sapporo, Japan 1275.19.81505 Boehringer Ingelheim Investigational Site Ibaraki, Koga, Japan 1275.19.81533 Boehringer Ingelheim Investigational Site Ibaraki, Naka, Japan 1275.19.81516 Boehringer Ingelheim Investigational Site Kanagawa, Kawasaki, Japan 1275.19.81537 Boehringer Ingelheim Investigational Site Kanagawa, Sagamihara, Japan 1275.19.81538 Boehringer Ingelheim Investigational Site Kanagawa, Yokohama, Japan 1275.19.81520 Boehringer Ingelheim Investigational Site Kyoto, Kyoto, Japan 1275.19.81521 Boehringer Ingelheim Investigational Site Kyoto, Kyoto, Japan 1275.19.81539 Boehringer Ingelheim Investigational Site Kyoto, Kyoto, Japan 1275.19.81517 Boehringer Ingelheim Investigational Site Nagano, Matsumoto, Japan 1275.19.81518 Boehringer Ingelheim Investigational Site Nagano, Matsumoto, Japan 1275.19.81525 Boehringer Ingelheim Investigational Site Osaka, Higashi-Osaka, Japan 1275.19.81523 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81526 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81527 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81540 Boehringer Ingelheim Investigational Site Osaka, Osaka, Japan 1275.19.81522 Boehringer Ingelheim Investigational Site Osaka, Suita, Japan 1275.19.81524 Boehringer Ingelheim Investigational Site Osaka, Takatsuki, Japan 1275.19.81535 Boehringer Ingelheim Investigational Site Saitama, Hanno, Japan 1275.19.81506 Boehringer Ingelheim Investigational Site Saitama, Kawagoe, Japan 1275.19.81507 Boehringer Ingelheim Investigational Site Saitama, Saitama, Japan 1275.19.81534 Boehringer Ingelheim Investigational Site Saitama, Tokorozawa, Japan 1275.19.81509 Boehringer Ingelheim Investigational Site Tokyo, Chiyoda-ku, Japan 1275.19.81508 Boehringer Ingelheim Investigational Site Tokyo, Chuo-ku, Japan 1275.19.81512 Boehringer Ingelheim Investigational Site Tokyo, Chuo-ku, Japan 1275.19.81515 Boehringer Ingelheim Investigational Site Tokyo, Hachioji, Japan 1275.19.81511 Boehringer Ingelheim Investigational Site Tokyo, Koto-ku, Japan 1275.19.81513 Boehringer Ingelheim Investigational Site Tokyo, Meguro-ku, Japan 1275.19.81514 Boehringer Ingelheim Investigational Site Tokyo, Shinagawa-ku, Japan 1275.19.81510 Boehringer Ingelheim Investigational Site Tokyo, Shinjuku-ku, Japan Less << |
NCT00954447 | - | Completed | - | - | |
NCT01826370 | Diabetes Mellitus, Type 2 | TERMINATED | 2025-10-13 | Boehringer Ingelheim Investiga... More >>tional Site 43, Agoo, La Union, Philippines|Boehringer Ingelheim Investigational Site 40, Angeles City, Pampanga, Philippines|Boehringer Ingelheim Investigational Site 31, Angono, Rizal, Philippines|Boehringer Ingelheim Investigational Site 32, Antipolo, Rizal, Philippines|Boehringer Ingelheim Investigational Site 27, Aparri, Cagayan, Philippines|Boehringer Ingelheim Investigational Site 4, Batangas, Philippines|Boehringer Ingelheim Investigational Site 48, Butuan City, Agusan del Norte, Philippines|Boehringer Ingelheim Investigational Site 12, Cabanatuan, Nueva Ecija, Philippines|Boehringer Ingelheim Investigational Site 23, Cagayan de Oro, Philippines|Boehringer Ingelheim Investigational Site 3, Caloocan, Philippines|Boehringer Ingelheim Investigational Site 42, Cardona, Rizal, Philippines|Boehringer Ingelheim Investigational Site 25, Cebu, Philippines|Boehringer Ingelheim Investigational Site 44, Dagupan, Pangasinan, Philippines|Boehringer Ingelheim Investigational Site 49, Iligan City, Lanao del Norte, Philippines|Boehringer Ingelheim Investigational Site 2, Iloilo, Philippines|Boehringer Ingelheim Investigational Site 45, Iriga City, Camarines Sur, Philippines|Boehringer Ingelheim Investigational Site 20, Laoag, Ilocos Norte, Philippines|Boehringer Ingelheim Investigational Site 24, Las Pinas, Philippines|Boehringer Ingelheim Investigational Site 7, Legazpi, Albay, Philippines|Boehringer Ingelheim Investigational Site 35, Lucena, Quezon, Philippines|Boehringer Ingelheim Investigational Site 1, Makati, Philippines|Boehringer Ingelheim Investigational Site 39, Malolos, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 37, Mandaluyong City, Philippines|Boehringer Ingelheim Investigational Site 28, Manila, Philippines|Boehringer Ingelheim Investigational Site 5, Marikina, Philippines|Boehringer Ingelheim Investigational Site 16, Meycauyan, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 47, Naga City, Camarines Sur, Philippines|Boehringer Ingelheim Investigational Site 15, Olongapo, Philippines|Boehringer Ingelheim Investigational Site 10, Pampanga, Philippines|Boehringer Ingelheim Investigational Site 19, Paranaque, Philippines|Boehringer Ingelheim Investigational Site 51, Pasay City, Philippines|Boehringer Ingelheim Investigational Site 30, Pasig, Philippines|Boehringer Ingelheim Investigational Site 34, Puerto Princesa, Palawan, Philippines|Boehringer Ingelheim Investigational Site 26, Quezon City, Philippines|Boehringer Ingelheim Investigational Site 11, Rosales, Pangasinan, Philippines|Boehringer Ingelheim Investigational Site 21, San Fernando, La Union, Philippines|Boehringer Ingelheim Investigational Site 9, San Fernando, Pampanga, Philippines|Boehringer Ingelheim Investigational Site 13, San Jose, Nueva Ecija, Philippines|Boehringer Ingelheim Investigational Site 29, San Juan, Philippines|Boehringer Ingelheim Investigational Site 8, San Pablo, Laguna, Philippines|Boehringer Ingelheim Investigational Site 50, San Pedro, Laguna, Philippines|Boehringer Ingelheim Investigational Site 41, Santiago city, Isabela, Philippines|Boehringer Ingelheim Investigational Site 36, Sogod, Southern Leyte, Philippines|Boehringer Ingelheim Investigational Site 38, Sta.Maria, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 6, Tacloban, Philippines|Boehringer Ingelheim Investigational Site 33, Tagbilaran, Bohol, Philippines|Boehringer Ingelheim Investigational Site 14, Tuguegarao, Cagayan, Philippines|Boehringer Ingelheim Investigational Site 18, Urdaneta, Pangasinan, Philippines|Boehringer Ingelheim Investigational Site 46, Valencia City Bukidnon, Philippines|Boehringer Ingelheim Investigational Site 17, Valenzuela, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 22, Zamboanga, Philippines Less << | |
NCT02183480 | Healthy | Phase 1 | Completed | - | - |
NCT02223026 | Healthy | Phase 1 | Completed | - | - |
NCT01845077 | - | Completed | - | - | |
NCT01084005 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01216397 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1288.6.1 Boehringer Ingelheim Investigational Site Ingelheim, Germany Less << |
NCT01084005 | - | Completed | - | - | |
NCT02183584 | Healthy | Phase 1 | Completed | - | - |
NCT01216397 | - | Completed | - | - | |
NCT01826370 | Diabetes Mellitus, Type 2 | TERMINATED | 2025-10-13 | Boehringer Ingelheim Investiga... More >>tional Site 43, Agoo, La Union, Philippines|Boehringer Ingelheim Investigational Site 40, Angeles City, Pampanga, Philippines|Boehringer Ingelheim Investigational Site 31, Angono, Rizal, Philippines|Boehringer Ingelheim Investigational Site 32, Antipolo, Rizal, Philippines|Boehringer Ingelheim Investigational Site 27, Aparri, Cagayan, Philippines|Boehringer Ingelheim Investigational Site 4, Batangas, Philippines|Boehringer Ingelheim Investigational Site 48, Butuan City, Agusan del Norte, Philippines|Boehringer Ingelheim Investigational Site 12, Cabanatuan, Nueva Ecija, Philippines|Boehringer Ingelheim Investigational Site 23, Cagayan de Oro, Philippines|Boehringer Ingelheim Investigational Site 3, Caloocan, Philippines|Boehringer Ingelheim Investigational Site 42, Cardona, Rizal, Philippines|Boehringer Ingelheim Investigational Site 25, Cebu, Philippines|Boehringer Ingelheim Investigational Site 44, Dagupan, Pangasinan, Philippines|Boehringer Ingelheim Investigational Site 49, Iligan City, Lanao del Norte, Philippines|Boehringer Ingelheim Investigational Site 2, Iloilo, Philippines|Boehringer Ingelheim Investigational Site 45, Iriga City, Camarines Sur, Philippines|Boehringer Ingelheim Investigational Site 20, Laoag, Ilocos Norte, Philippines|Boehringer Ingelheim Investigational Site 24, Las Pinas, Philippines|Boehringer Ingelheim Investigational Site 7, Legazpi, Albay, Philippines|Boehringer Ingelheim Investigational Site 35, Lucena, Quezon, Philippines|Boehringer Ingelheim Investigational Site 1, Makati, Philippines|Boehringer Ingelheim Investigational Site 39, Malolos, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 37, Mandaluyong City, Philippines|Boehringer Ingelheim Investigational Site 28, Manila, Philippines|Boehringer Ingelheim Investigational Site 5, Marikina, Philippines|Boehringer Ingelheim Investigational Site 16, Meycauyan, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 47, Naga City, Camarines Sur, Philippines|Boehringer Ingelheim Investigational Site 15, Olongapo, Philippines|Boehringer Ingelheim Investigational Site 10, Pampanga, Philippines|Boehringer Ingelheim Investigational Site 19, Paranaque, Philippines|Boehringer Ingelheim Investigational Site 51, Pasay City, Philippines|Boehringer Ingelheim Investigational Site 30, Pasig, Philippines|Boehringer Ingelheim Investigational Site 34, Puerto Princesa, Palawan, Philippines|Boehringer Ingelheim Investigational Site 26, Quezon City, Philippines|Boehringer Ingelheim Investigational Site 11, Rosales, Pangasinan, Philippines|Boehringer Ingelheim Investigational Site 21, San Fernando, La Union, Philippines|Boehringer Ingelheim Investigational Site 9, San Fernando, Pampanga, Philippines|Boehringer Ingelheim Investigational Site 13, San Jose, Nueva Ecija, Philippines|Boehringer Ingelheim Investigational Site 29, San Juan, Philippines|Boehringer Ingelheim Investigational Site 8, San Pablo, Laguna, Philippines|Boehringer Ingelheim Investigational Site 50, San Pedro, Laguna, Philippines|Boehringer Ingelheim Investigational Site 41, Santiago city, Isabela, Philippines|Boehringer Ingelheim Investigational Site 36, Sogod, Southern Leyte, Philippines|Boehringer Ingelheim Investigational Site 38, Sta.Maria, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 6, Tacloban, Philippines|Boehringer Ingelheim Investigational Site 33, Tagbilaran, Bohol, Philippines|Boehringer Ingelheim Investigational Site 14, Tuguegarao, Cagayan, Philippines|Boehringer Ingelheim Investigational Site 18, Urdaneta, Pangasinan, Philippines|Boehringer Ingelheim Investigational Site 46, Valencia City Bukidnon, Philippines|Boehringer Ingelheim Investigational Site 17, Valenzuela, Bulacan, Philippines|Boehringer Ingelheim Investigational Site 22, Zamboanga, Philippines Less << | |
NCT02004366 | Type 2 Diabetes | Phase 4 | Completed | - | United States, Colorado ... More >> University of Colorado Denver, Colorado, United States, 80220 United States, Georgia Emory University Hospital Atlanta, Georgia, United States, 30322 Grady Memorial Hospital Atlanta, Georgia, United States United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Massachusetts Boston Medical Center Boston, Massachusetts, United States, 02118 Less << |
NCT00935220 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, California ... More >> 1218.55.0006 Boehringer Ingelheim Investigational Site Cypress, California, United States United States, Florida 1218.55.0008 Boehringer Ingelheim Investigational Site Deland, Florida, United States 1218.55.0004 Boehringer Ingelheim Investigational Site Miami, Florida, United States United States, Maryland 1218.55.0005 Boehringer Ingelheim Investigational Site Baltimore, Maryland, United States United States, New York 1218.55.0003 Boehringer Ingelheim Investigational Site New York, New York, United States United States, Texas 1218.55.0001 Boehringer Ingelheim Investigational Site Dallas, Texas, United States Less << |
NCT02004366 | - | Completed | - | - | |
NCT00935220 | - | Completed | - | - | |
NCT02240680 | - | Completed | - | - | |
NCT01943019 | Schizophrenia | PHASE1 | TERMINATED | 2025-08-18 | Pusat Perubatan Universiti Keb... More >>angsaan Malaysia, Bandar Tun Razak, Kuala Lumpur, 56000, Malaysia Less << |
NCT03011177 | Type2 Diabetes Mellitus | Phase 4 | Recruiting | April 2019 | Korea, Republic of ... More >> Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: JY Park 82216887575 Less << |
NCT02429232 | Osteoporosis ... More >>Diabetes Mellitus Less << | Phase 4 | Unknown | December 2017 | - |
NCT03429543 | Diabetes Mellitus, Type 2 | Phase 3 | Recruiting | January 31, 2022 | - |
NCT03667300 | Type2 Diabetes Mellitus ... More >> Albuminuria Renal Insufficiency Less << | Phase 2 | Enrolling by invitation | January 31, 2019 | Korea, Republic of ... More >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Less << |
NCT02084082 | - | Completed | - | - | |
NCT02240680 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT02084056 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1288.11.1 Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT02121509 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1288.10.1 Boehringer Ingelheim Investigational Site Ingelheim, Germany Less << |
NCT02121509 | - | Completed | - | - | |
NCT01540487 | Healthy | Phase 1 | Completed | - | China ... More >> 1288.5.86001 Boehringer Ingelheim Investigational Site Beijing, China Less << |
NCT02084056 | - | Completed | - | - | |
NCT01903070 | Diabetes Mellitus | PHASE4 | COMPLETED | 2025-04-16 | Profil Institut für Stoffwechs... More >>elforschung GmbH, Neuss, NRW, 41460, Germany Less << |
NCT02851745 | Diabetes Mellitus, Type 2 ... More >> Left Ventricular Systolic Dysfunction Less << | Phase 3 | Active, not recruiting | April 2019 | Italy ... More >> Azienda Ospedaliera Papa Giovanni Xxiii Bergamo, BG, Italy, 24127 P.O. Garibaldi-Nesima Catania, CT, Italy, 95122 Ospedale Casa Sollievo Della Sofferenza San Giovanni Rotondo, FG, Italy, 71013 Ospedale Villa Scassi Genova, GE, Italy, 16149 Iclas-Istituto Clinico Ligure Alta Spec. Rapallo, GE, Italy, 16035 Ospedale San Giuseppe Da Copertino Copertino, LE, Italy, 73043 Ospedale San Raffaele Milano, Lombardia, Italy, 20010 Policlinico G. Martino Messina, ME, Italy, 98124 Irccs Policlinico Multimedica Sesto San Giovanni, MI, Italy, 20099 A.O. Santa Croce e Carle Cuneo, Piemonte, Italy, 12100 Ospedale Sandro Pertini Roma, RM, Italy, 00157 Ospedale Maggiore Chieri, TO, Italy, 10023 Ospedale Mauriziano Torino, TO, Italy, 10128 Azienda Ospedaliera Santa Maria Terni, TR, Italy, 05100 Aas 1 Triestina Trieste, TS, Italy, 34148 Centro Cardiologico Monzino Milano, Italy, 20138 Aorn Osp. Dei Colli- Po Vincenzo Monaldi Napoli, Italy, 80131 Seconda Universita' Di Napoli Napoli, Italy, 80131 Casa di Cura Villa Bianca Trento, Italy, 38100 Less << |
NCT01540487 | - | Completed | - | - | |
NCT02084082 | Healthy | Phase 1 | Completed | - | Germany ... More >> 1288.9.1 Boehringer Ingelheim Investigational Site Biberach, Germany Less << |
NCT03051243 | DM2 | Phase 3 | Not yet recruiting | November 1, 2019 | - |
NCT02015299 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Netherlands ... More >> University Medical Center Groningen Groningen, Netherlands, 9700 RB Less << |
NCT02857946 | Healthy | Phase 1 | Completed | - | Egypt ... More >> Genuine Research Center GRC Cairo, Egypt, 11757 Less << |
NCT02061969 | Diabetes | Phase 4 | Completed | - | United States, Georgia ... More >> Crestvew Nursing Home Atlanta, Georgia, United States, 30315 Budd Terrace Nursing Home Atlanta, Georgia, United States, 30322 Wesley Woods Nursing Home Atlanta, Georgia, United States, 30322 VA Nursing Home Decatur, Georgia, United States, 30033 Less << |
NCT02401880 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Germany ... More >> Profil Mainz GmbH & Co. KG Mainz, Germany, 55116 Profil Institut für Stoffwechselforschung GmbH Neuss, Germany, 41460 Less << |
NCT02061969 | - | Completed | - | - | |
NCT03250052 | Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Kyungpook National University Hospital Seoul, Korea, Republic of Less << |
NCT02212782 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... More >> Chonbuk National University Hospital Jeonju, Jeollabukdo, Korea, Republic of, 561-712 Less << |
NCT02758171 | - | Completed | - | - | |
NCT03609294 | Hypertension ... More >>Diabetes Less << | Phase 1 | Recruiting | May 30, 2019 | Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Dahak-ro, Korea, Republic of, 03080 Contact: Kyung-Sang Yu, MD, PhD Less << |
NCT03004612 | Prediabetic State ... More >> Insulin Resistance Less << | Phase 4 | Active, not recruiting | August 2018 | Mexico ... More >> Universidad de Guanajuato León, Guanajuato, Mexico, 37670 Less << |
NCT02350478 | Type 2 Diabetes ... More >> Coronary Artery Disease Less << | Phase 4 | Completed | - | Austria ... More >> Medical University of Graz, Department for Internal Medicine Graz, Austria, 8036 Less << |
NCT01835678 | Type 2-diabetes | Phase 3 | Completed | - | Germany ... More >> Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Nuremberg, Germany, 90471 Less << |
NCT02758171 | Healthy | Phase 1 | Completed | - | Germany ... More >> Humanpharmakologisches Zentrum Biberach Biberach, Germany, 88397 Less << |
NCT02376075 | Arterial Hypertension ... More >> Albuminuria Less << | Phase 3 | Completed | - | Germany ... More >> Profil Mainz GmbH & Co. KG Mainz, Rhineland-Palatinate, Germany, 55116 Less << |
NCT02815644 | Healthy | Phase 1 | Completed | - | Japan ... More >> SOUSEIKAI Sumida Hospital Tokyo, Sumida-ku, Japan, 133-0004 Less << |
NCT02815644 | - | Completed | - | - | |
NCT03320031 | Type 2 Diabetes Mellitus ... More >> Peritoneal Dialysis Less << | Phase 4 | Recruiting | December 2019 | China, Guangdong ... More >> endocrinology department of the first affiliated hospital of Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Yanbing Li, MD,PhD 8602087334331 easd04lyb@126.com Principal Investigator: Yanbing Li, MD,PhD Less << |
NCT02106104 | Type 2 Diabetes | Phase 4 | Completed | - | Netherlands ... More >> VU University Medical Center Amsterdam, Netherlands, 1081 HV Less << |
NCT01617824 | Type 2 Diabetes ... More >> Chronic Renal Failure Less << | Phase 4 | Completed | - | Italy ... More >> University Hospital Diabetes Outpatient Clinic Padova, Italy, 35100 Less << |
NCT02467478 | Type 2 Diabetes ... More >> Impaired Renal Function Less << | Phase 4 | Recruiting | December 2019 | United States, District of Col... More >>umbia The George Washington University Medical Faculty Associates Recruiting Washington, District of Columbia, United States, 20037 Contact: Fiona Dore, BS 202-741-2342 fdore@mfa.gwu.edu Less << |
NCT02725502 | Type 1 Diabetes Mellitus | Not Applicable | Unknown | May 2016 | India ... More >> Department of Endocrinology, PGIMER Recruiting Chandigarh, India, 160012 Contact: Snajay Kr Bhadada, MD, DM bhadadask@rediffmail.com Contact: Soham Mukherjee, MD 9914743222 drsoham.mukherjee@gmail.com Principal Investigator: sanjay Kr Bhadada, MD, DM Less << |
NCT02372630 | Type 2 Diabetes | Phase 4 | Active, not recruiting | May 2018 | United States, New York ... More >> ECMC Ambulatory Center, 3rd Floor Buffalo, New York, United States, 14215 Less << |
NCT03338803 | Diabetes Mellitus, Type 2 | COMPLETED | 2018-02-02 | Optum, Eden Prairie, Minnesota... More >>, 55344, United States Less << | |
NCT02077309 | Diabetes Mellitus Type 2 (T2DM... More >>) Vascular Inflammation Plaque Morphology Less << | Phase 3 | Terminated(bad recruitment of ... More >>suitable participants, just 4 patients in one year) Less << | - | Germany ... More >> Department of Internal Medicine I, University Hospital Aachen, Germany, 52074 Netherlands Cardiovascular Research Institute Maastricht (CARIM) Maastricht, Netherlands, 6229 Less << |
NCT02442817 | Schizophrenia | PHASE4 | COMPLETED | 2018-03-02 | University of Nevada School of... More >> Medicine, Reno, Nevada, 89503, United States Less << |
NCT02280174 | Type 2 Diabetes | Phase 4 | Unknown | October 2016 | Argentina ... More >> National University of Formosa Recruiting Formosa, Argentina, 3600 Contact: Juan Pa Nogueira, MD/PhD 00543704425447 nogueirajuanpatricio@gmail.com Less << |
NCT02097342 | Type 2 Diabetes Mellitus ... More >> Insulin Sensitivity/Resistance Less << | Phase 4 | Unknown | January 2015 | India ... More >> Postgraduate Institute of Medical Education & Research Recruiting Chandigarh, India, 160012 Contact: Anil Bhansali, MD DM anilbhansaliendocrine@gmail.com Less << |
NCT02752113 | Diabetes Mellitus Type 2 | Phase 3 | Recruiting | January 2019 | Germany ... More >> Clinical Research Center, Dept of Nephrology and Hypertenison, University of Erlangen/Nürnberg Recruiting Erlangen, Bavaria, Germany, 91054 Contact: Christian Ott, MD +49-9131-85 ext 36245 christian.ott@uk-erlangen.de Contact: Roland Schmieder, Prof. MD +49 9131 85 ext 36245 roland.schmieder@uk-erlangen.de Principal Investigator: Roland Schmieder, Prof. MD Sub-Investigator: Christian Ott, MD Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.12mL 0.42mL 0.21mL |
10.58mL 2.12mL 1.06mL |
21.16mL 4.23mL 2.12mL |