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Chemical Structure| 796967-16-3 Chemical Structure| 796967-16-3

Structure of Linifanib
CAS No.: 796967-16-3

Chemical Structure| 796967-16-3

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Linifanib is a potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively.

Synonyms: ABT-869; AL-39324

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Product Details of Linifanib

CAS No. :796967-16-3
Formula : C21H18FN5O
M.W : 375.40
SMILES Code : O=C(NC1=CC(C)=CC=C1F)NC2=CC=C(C3=CC=CC4=C3C(N)=NN4)C=C2
Synonyms :
ABT-869; AL-39324
MDL No. :MFCD11840918
InChI Key :MPVGZUGXCQEXTM-UHFFFAOYSA-N
Pubchem ID :11485656

Safety of Linifanib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Linifanib

RTK

Isoform Comparison

Biological Activity

Target
  • VEGFR1

    VEGFR1/FLT1, IC50:3 nM

  • VEGFR3

    VEGFR3/FLT4, IC50:190 nM

  • VEGFR2

    VEGFR2/KDR, IC50:4 nM

  • PDGFRβ

    PDGFRβ, IC50:66 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03481842 Endometriosis ... More >> Endometriosis Ovary Endometriosis Externa Endometriosis, Rectum Less << Phase 1 Phase 2 Not yet recruiting September 30, 2018 Switzerland ... More >> BioGene Pharmaceutical Ltd. Not yet recruiting Basel, Вâlе, Switzerland, 4057 Contact: J. Łanevska, Dr       jula.edu@yahoo.com Less <<
NCT00707889 Advanced Colorectal Cancer ... More >> Adenocarcinoma of the Colon Adenocarcinoma of the Rectum Less << Phase 2 Completed - -
NCT00716534 Advanced or Metastatic Non-Sma... More >>ll Cell Lung Cancer Less << Phase 2 Completed - -
NCT00718380 Solid Tumor PHASE1 COMPLETED 2025-06-12 -
NCT00486538 Advanced Renal Cell Carcinoma PHASE2 COMPLETED 2025-06-12 Site Reference ID/Investigator... More >># 7193, Sacramento, California, 95817, United States|Site Reference ID/Investigator# 5243, Washington, District of Columbia, 20010, United States|Site Reference ID/Investigator# 5384, Chicago, Illinois, 60637, United States|Site Reference ID/Investigator# 11662, Boston, Massachusetts, 02114, United States|Site Reference ID/Investigator# 11663, Boston, Massachusetts, 02114, United States|Site Reference ID/Investigator# 5379, Boston, Massachusetts, 02114, United States|Site Reference ID/Investigator# 5380, Lebanon, New Hampshire, 03756-0001, United States|Site Reference ID/Investigator# 5249, Philadelphia, Pennsylvania, 19111, United States|Site Reference ID/Investigator# 6278, Philadelphia, Pennsylvania, 19111, United States|Site Reference ID/Investigator# 6269, Pittsburgh, Pennsylvania, 15232, United States|Site Reference ID/Investigator# 7300, Charleston, South Carolina, 29425, United States|Site Reference ID/Investigator# 6796, Houston, Texas, 77030-4009, United States|Site Reference ID/Investigator# 6566, Vancouver, V5Z 4E6, Canada Less <<
NCT00733187 Advanced Solid Tumors PHASE1 COMPLETED 2025-06-12 -
NCT00645177 Metastatic Breast Cancer Phase 2 Completed - United States, California ... More >> Site Reference ID/Investigator# 8352 San Francisco, California, United States, 94115 United States, Illinois Site Reference ID/Investigator# 6920 Harvey, Illinois, United States, 60426 Mexico Site Reference ID/Investigator# 10181 Durango, DGO., Mexico, CP 34000 Less <<
NCT01009593 Hepatocellular Carcinoma Non-r... More >>esectable Hepatocellular Carcinoma Recurrent Carcinoma, Hepatocellular Liver Diseases Neoplasms by Histologic Type Digestive System Neoplasms Carcinoma Liver Neoplasms Neoplasms Neoplasms by Site Digestive System Diseases Adenocarcinoma Neoplasms, Glandular and Epithelial Less << Phase 3 Terminated(See termination rea... More >>son in detailed description) Less << - -
NCT01225302 Non-Small Cell Lung Cancer Phase 1 Completed - -
NCT01286974 Advanced Solid Tumors Phase 1 Terminated(Terminated early, S... More >>ponsor Decision) Less << - United States, Ohio ... More >> Site Reference ID/Investigator# 40942 Cleveland, Ohio, United States, 44195 Site Reference ID/Investigator# 53663 Cleveland, Ohio, United States, 44195 Less <<
NCT00517790 Non-Small Cell Lung Cancer (NS... More >>CLC) Less << Phase 2 Completed - -
NCT01365910 Recurrent Colon Cancer ... More >> Recurrent Rectal Cancer Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer Less << Phase 2 Terminated(Interim analysis de... More >>termined the study did not meet criteria to proceed) Less << - United States, Tennessee ... More >> Vanderbilt Cool Springs Franklin, Tennessee, United States, 37067 Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232-6838 Less <<
NCT01114191 Solid Tumors Phase 1 Completed - United States, Michigan ... More >> Site Reference ID/Investigator# 35784 Detroit, Michigan, United States, 48201 United States, New Hampshire Site Reference ID/Investigator# 36527 Lebanon, New Hampshire, United States, 03756-0001 Less <<
NCT01413893 Advanced Solid Tumors Phase 1 Completed - -
NCT01365910 - Terminated(Interim analysis de... More >>termined the study did not meet criteria to proceed) Less << - -
NCT01401933 Advanced Solid Tumors Phase 1 Completed - United States, Arizona ... More >> Site Reference ID/Investigator# 49953 Tucson, Arizona, United States, 85724-5024 United States, Wisconsin Site Reference ID/Investigator# 49952 Madison, Wisconsin, United States, 53792 Less <<
NCT01506934 Advanced or Metastatic Solid T... More >>umors Less << Phase 1 Terminated(Sponsor decision) - United States, Maryland ... More >> Site Reference ID/Investigator# 51465 Baltimore, Maryland, United States, 21231 United States, Michigan Site Reference ID/Investigator# 61282 Detroit, Michigan, United States, 48201 United States, New Hampshire Site Reference ID/Investigator# 51463 Lebanon, New Hampshire, United States, 03756-0001 United States, Texas Site Reference ID/Investigator# 52122 San Antonio, Texas, United States, 78229 Less <<
NCT01381341 Advanced Solid Tumors Phase 1 Completed - United States, Washington ... More >> Site Reference ID/Investigator# 51403 Tacoma, Washington, United States, 98405 Less <<
NCT00517920 Advanced Hepatocellular Carcin... More >>oma Less << PHASE2 COMPLETED 2025-06-12 Site Reference ID/Investigator... More >># 7726, Philadelphia, Pennsylvania, 19107, United States|Site Reference ID/Investigator# 7169, Toronto, M5G 2M9, Canada|Site Reference ID/Investigator# 5837, Vancouver, V5Z 4E6, Canada|Site Reference ID/Investigator# 5235, Singapore, 119228, Singapore|Site Reference ID/Investigator# 5611, Singapore, 169610, Singapore|Site Reference ID/Investigator# 6265, Taipei, 10002, Taiwan Less <<
NCT00754104 Solid Tumors Phase 1 Withdrawn - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.32mL

2.66mL

1.33mL

26.64mL

5.33mL

2.66mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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