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Chemical Structure| 1627710-50-2 Chemical Structure| 1627710-50-2

Structure of LJH685
CAS No.: 1627710-50-2

Chemical Structure| 1627710-50-2

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LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.

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Product Details of LJH685

CAS No. :1627710-50-2
Formula : C22H21F2N3O
M.W : 381.42
SMILES Code : OC1=C(F)C=C(C2=C(C3=CC=C(N4CCN(C)CC4)C=C3)C=CN=C2)C=C1F
MDL No. :MFCD29924738
InChI Key :IKUFKDGKRLMXEX-UHFFFAOYSA-N
Pubchem ID :73010393

Safety of LJH685

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of LJH685

MAPK
PI3K-AKT

Isoform Comparison

Biological Activity

Description
LJH685 is a strong, ATP-competitive, and selective inhibitor of RSK (ribosomal S6 kinase), effectively inhibiting the biochemical activities of RSK1, RSK2, and RSK3 with IC50 values of 6, 5, and 4 nM, respectively[1].

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Bio Calculators
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1 mM

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10 mM

2.62mL

0.52mL

0.26mL

13.11mL

2.62mL

1.31mL

26.22mL

5.24mL

2.62mL

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