Structure of Lobaplatin
CAS No.: 135558-11-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Lobaplatin is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Its antitumour activity results from the formation of DNA-drug adducts, mainly as GG and AG intra-strand cross-links.
Synonyms: D-19466
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CAS No. : | 135558-11-1 |
Formula : | C9H18N2O3Pt |
M.W : | 397.33 |
SMILES Code : | CC([O-]1)C([O-][Pt]21[NH2+]CC(CC3)C3C[NH2+]2)=O |
Synonyms : |
D-19466
|
MDL No. : | MFCD00866545 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03731442 | Esophageal Cancer | Phase 3 | Recruiting | October 31, 2027 | China, Beijing ... More >> Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD Less << |
NCT03328234 | IMRT With or Without Concurren... More >>t Chemotherapy for Esophageal Cancer Less << | Phase 3 | Recruiting | December 31, 2022 | China ... More >> Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, China, 100021 Contact: Xin Wang, MD +861013311583220 beryl_wx2000@163.com Less << |
NCT03308552 | Esophageal Neoplasms | Phase 3 | Recruiting | August 30, 2021 | China, Beijing ... More >> Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Recruiting Beijing, Beijing, China, 100021 Contact: Zefen Xiao, MD Less << |
NCT02856126 | Hepatocellular Carcinoma | Phase 3 | Recruiting | August 2018 | China, Guangdong ... More >> Dongguan People's Hospital Recruiting Dongguan, Guangdong, China, 523059 Contact: Wusheng Yu, MD 13827285010 yuwusheng1998@126.com Cancer Center Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Ming Shi, MD 8620-87343115 shiming@mail.sysu.edu.cn The First Affiliated Hospital, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Guosheng Tan, MD 13725254145 tgs1976@163.com Guangzhou Twelfth People 's Hospital Recruiting Guangzhou, Guangdong, China, 510620 Contact: Yuanmin Zhou, MD 15521278919 13430288977@139.com Principal Investigator: Jinghua Chen, MD Kaiping Central Hospital Recruiting Kaiping, Guangdong, China, 529300 Contact: Shijie Zhang, MD 13717287622 Shijie_9262511@163.com China, Hunan The First Affiliated Hospital of University Of South China Recruiting Hengyang, Hunan, China, 421001 Contact: Xiaoping Wu, MD 13975486015 wxp19730806@sina.com China, Shanxi The First Affiliated Hospital Of Xi'an Jiaotong University Recruiting Xi'an, Shanxi, China, 710061 Contact: Xin Zheng, MD 13649265446 183421344@qq.com Less << |
NCT01229839 | Hepatocellular Carcinoma | Phase 3 | Unknown | August 2018 | China, Guangdong ... More >> Cancer Center Sun Yat-sen University Recruiting Guangzhou, Guangdong, China Contact: Ming Shi, MD 86-2087343582 ext 86-2087343582 shiming@mail.sysu.edu.cn Contact: Rong Ping Guo, MD 86-2087343117 ext 86-2087343117 guorongp@mail.sysu.edu.cn Principal Investigator: Ming Shi, MD Less << |
NCT01259414 | Hepatocellular Carcinoma | Phase 3 | Unknown | January 2017 | China, Guangdong ... More >> Cancer Center Sun Yat-sen University Recruiting Guangzhou, Guangdong, China Contact: Ming Shi 86-2087343582 ext 86-2087343582 shiming@mail.sysu.edu.cn Contact: Ping Rong Guo 86-2087343117 ext 86-2087343117 guorongp@mail.sysu.edu.cn Principal Investigator: Ming Shi Less << |
NCT02435953 | Hepatocellular Carcinoma ... More >> Chemoembolization, Therapeutic Ablation Techniques, RFA Less << | Phase 4 | Recruiting | - | China, Guangdong ... More >> Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-sen University Cancer Center, Recruiting Guangzhou, Guangdong, China, 500060 Contact: Ming Zhao, doctor +86 020 87343272 zhaoming@sysucc.org.cn Contact: Tao Pan, doctor +86 020 87343271 pantao0909@hotmail.com Less << |
NCT02973685 | HepatoCellular Carcinoma | Phase 3 | Recruiting | October 2019 | China, Guangdong ... More >> Dongguan People's Hospital Recruiting Dongguan, Guangdong, China, 523059 Contact: Wusheng Yu, MD 13827285010 yuwusheng1998@126.com Cancer Center Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Ming Shi, MD 8620-87343115 shiming@mail.sysu.edu.cn The First Affiliated Hospital, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Guosheng Tan, MD 13725254145 tgs1976@163.com Guangzhou Twelfth People's Hospital Recruiting Guangzhou, Guangdong, China, 510620 Contact: Yuanmin Zhou, MD 15521278919 13430288977@139.com Principal Investigator: Jinghua Chen, MD Kaiping Central Hospital Recruiting Kaiping, Guangdong, China, 529300 Contact: Shijie Zhang, MD 13717287622 Shijie_9262511@163.com China, Hunan The First Affiliated Hospital of University Of South China Recruiting Hengyang, Hunan, China, 421001 Contact: Xiaoping Wu, MD 13975486015 wxp19730806@sina.com China, Shanxi The First Affiliated Hospital Of Xi'an Jiaotong University Recruiting Xi'an, Shanxi, China, 710061 Contact: Xin Zheng, MD 13649265446 183421344@qq.com Less << |
NCT03048123 | Hepatocellular Carcinoma | Phase 2 | Completed | - | China, Guangdong ... More >> Cancer Center Sun Yat-sen University Guangzhou, Guangdong, China, 510060 Less << |
NCT02430974 | Carcinoma, Non-Small-Cell Lung | Phase 2 | Unknown | January 2018 | - |
NCT03196869 | Locally Advanced Head and Neck... More >> Squamous Cell Carcinoma Less << | Phase 2 | Recruiting | August 12, 2022 | China, Guizhou ... More >> Cancer Hospital of Guizhou Medical University Recruiting Guiyang, Guizhou, China, 550000 Contact: Feng Jin, Bachelor 0851-86512802 jinf8865@yahoo.com.cn Sub-Investigator: Weili Wu, master Sub-Investigator: Jinhua Long, master Sub-Investigator: Yuanyuan Li, master Sub-Investigator: Xiuyun Gong, Bachelor Sub-Investigator: Xiaoxiao Chen, Bachelor Sub-Investigator: Juan Li, Bachelor Less << |
NCT03349827 | Peritoneal Metastases From Gas... More >>tric Cancer Less << | Not Applicable | Recruiting | November 30, 2020 | China, Hubei ... More >> Wuhan University Recruiting Wuhan, Hubei, China Contact: Bin Xiong +86 27 67813152 jyn1983@163.com Less << |
NCT02301091 | Hepatocellular Carcinoma | Phase 3 | Recruiting | October 2019 | China, Guangdong ... More >> Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-sen University Cancer Center, Recruiting Guangzhou, Guangdong, China, 500060 Contact: Ming Zhao, doctor +86 020 87343272 zhaoming@sysucc.org.cn Less << |
NCT01869088 | Hepatocellular Carcinoma | Phase 3 | Active, not recruiting | January 2018 | China, Guangdong ... More >> Cancer Center Sun Yat-sen University Guangzhou, Guangdong, China Less << |
NCT02678806 | HepatoCellular Carcinoma | Not Applicable | Recruiting | November 1, 2022 | China, Guangxi ... More >> TaoBai Recruiting Nanning, Guangxi, China, 530000 Contact: Bai Tao, MD +86 13878862632 25859373@qq.com Less << |
NCT02972320 | Extensive Stage Small Cell Lun... More >>g Cancer Less << | Phase 2 | Unknown | December 2018 | China, Liaoning ... More >> The First Affiliated Hospital of China Medical University Recruiting Shenyang, Liaoning, China, 110001 Contact: mingfang zhao, professor 13644055129 Less << |
NCT03606239 | Carcinoma, Non-Small-Cell Lung | Not Applicable | Not yet recruiting | July 1, 2024 | - |
NCT00646100 | Hepatocellular Carcinoma | Phase 4 | Completed | - | China, Guangdong ... More >> Cancer Canter Sun Yat-Sen University Guangzhou, Guangdong, China, 510060 Less << |
NCT03413436 | Esophageal Cancer | Phase 4 | Not yet recruiting | February 21, 2018 | China, Henan ... More >> Henan Cancer Hospital/The affiliated Cancer Hospital of ZhengZhou university ZhengZhou, Henan, China, 450008 Less << |
NCT03221608 | Colorectal Neoplasms | Phase 3 | Not yet recruiting | August 1, 2024 | - |
NCT03371693 | Ovarian Cancer ... More >> Ovary Neoplasm Ovarian Neoplasms Epithelial Ovarian Cancer Ovarian Cancer, Epithelial Hyperthermic Intraperitoneal Chemotherapy(HIPEC) Less << | Phase 3 | Active, not recruiting | December 30, 2020 | China, Hubei ... More >> Zhongnan Hospital of Wuhan University Wuhan, Hubei, China, 430072 Less << |
NCT01851746 | - | Unknown | February 2015 | China, Hubei ... More >> Zhongnan Hospital of Wuhan University Wuhan, Hubei, China, 430071 Less << | |
NCT03117257 | Locally Advanced Head and Neck... More >> Squamous Cell Carcinoma Less << | Phase 2 | Recruiting | August 20, 2021 | China, Guizhou ... More >> Cancer Hospital of Guizhou Medical University Recruiting Guiyang, Guizhou, China, 550000 Contact: Feng Jin, Bachelor 0851-86512802 jinf8865@yahoo.com.cn Sub-Investigator: Weili Wu, master Sub-Investigator: Jinhua Long, master Sub-Investigator: Yuanyuan Li, master Sub-Investigator: Xiuyun Gong, Bachelor Sub-Investigator: Xiaoxiao Chen, Bachelor Sub-Investigator: Mang Zhang, Bachelor Less << |
NCT01034683 | Esophageal Carcinoma | Phase 3 | Unknown | December 2010 | China, Shandong ... More >> Taian Cancer Hospital Taian, Shandong, China, 271000 Less << |
NCT03188497 | Acute Toxic Effects ... More >> Tumor Responses Less << | Phase 1 | Completed | - | China, Guangdong ... More >> the Fifth Hospital Affiliated to Sun Yat-Sen University Zhuhai, Guangdong, China, 519000 Less << |
NCT03613753 | Small-cell Lung Cancer | Phase 2 | Recruiting | June 1, 2021 | China, Guizhou ... More >> The affiliated hospital of Guizhou medical university Recruiting Guiyang, Guizhou, China, 550004 Contact: Shengfa Su, PhD,MD 86-13608550432 sushengfa2005@163.com Less << |
NCT01483300 | Breast Cancer | Phase 2 | Unknown | November 2014 | China, Heilongjiang ... More >> Cancer Hospital of Harbin Medical University Recruiting Harbin, Heilongjiang, China, 150081 Contact: Qingyuan Zhang, MD 86-451-86298276 zhma19650210@163.com Contact: Xinmei Kang, MD 86-451-86298683 kxm791107@163.com Principal Investigator: Qingyuan Zhang, MD Sub-Investigator: Xinmei Kang, MD Less << |
NCT03613597 | Small-cell Lung Cancer | Phase 2 | Recruiting | January 1, 2022 | China, Guizhou ... More >> The affiliated hospital of Guizhou medical university Recruiting Guiyang, Guizhou, China, 550004 Contact: Shengfa Su, PhD,MD 86-13608550432 sushengfa2005@163.com Less << |
NCT02099396 | Lobaplatin and Gemcitabine in ... More >>Combination, Second-line Treatments on Advanced Osteosarcoma Less << | Phase 2 Phase 3 | Unknown | - | - |
NCT03700359 | Small Cell Lung Carcinoma | Phase 2 | Not yet recruiting | November 29, 2021 | - |
NCT03210389 | Recurrent Nasopharyngeal Carci... More >>noma Less << | PHASE2 | UNKNOWN | 2025-12-21 | Department of Radiation Oncolo... More >>gy, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510000, China Less << |
NCT00493402 | Hepatocellular Carcinoma | Phase 3 | Completed | - | China, Guangdong ... More >> Cancer Center Sun Yat-sen University Guangzhou, Guangdong, China, 510060 Less << |
NCT01350206 | Hepatocellular Carcinoma With ... More >>PVTT Less << | Phase 4 | Unknown | May 2013 | China, Guangdong ... More >> Cancer Center Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Min-Shan Chen, M.D. Ph.D. (8620) 8734 3117 Chminsh@mail.sysu.edu.cn Principal Investigator: min-shan chen, M.D.,Ph.D. Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.52mL 0.50mL 0.25mL |
12.58mL 2.52mL 1.26mL |
25.17mL 5.03mL 2.52mL |
|
Dissolving Methods |
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
|
Tags: Lobaplatin | D-19466 | Aliphatic Cyclic Hydrocarbons | DNA Alkylator/Crosslinker | Platinum | Apoptosis Inducer | Bcl-2 | Caspase | Apoptosis | Others | Endogenous Metabolite | Organic Building Blocks | Transition Metal | Transition Metals | Apoptosis | Cell Apoptosis/Death Detection | Tumor Growth, Proliferation and Apoptosis | Parkinson'S Disease and Alzheimer'S Disease | Pyroptosis | DNA Damage | Small Molecule Positive Drugs | Steroids | Biological Buffers | Fluorescence Labeling Reagents | Fluorescent Dyes | Structure | Other Inhibitors/Agonists | 135558-11-1
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P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
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P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
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P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
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P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
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P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
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P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
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H221 | Flammable gas |
H222 | Extremely flammable aerosol |
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H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
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H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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