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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1435784-14-7 Chemical Structure| 1435784-14-7

Structure of Lometrexol hydrate
CAS No.: 1435784-14-7

Chemical Structure| 1435784-14-7

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Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2].

Synonyms: DDATHF hydrate

4.5 *For Research Use Only !

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Product Details of Lometrexol hydrate

CAS No. :1435784-14-7
Formula : C21H27N5O7
M.W : 461.47
SMILES Code : O=C(O)[C@@H](NC(C1=CC=C(CC[C@@H](CN2)CC3=C2NC(N)=NC3=O)C=C1)=O)CCC(O)=O.[H]O[H]
Synonyms :
DDATHF hydrate

Safety of Lometrexol hydrate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of Lometrexol hydrate

pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL

 

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