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Chemical Structure| 79794-75-5 Chemical Structure| 79794-75-5

Structure of Loratadine
CAS No.: 79794-75-5

Chemical Structure| 79794-75-5

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Loratadine is an inverse agonist of peripheral histamine H1-receptor with IC50 of > 32 μM.

Synonyms: Loratidine; SCH 29851; Wyeth Brand of Loratadine

4.5 *For Research Use Only !

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Product Details of Loratadine

CAS No. :79794-75-5
Formula : C22H23ClN2O2
M.W : 382.88
SMILES Code : ClC1=CC=C2C(CCC3=C(/C2=C4CCN(CC\4)C(OCC)=O)N=CC=C3)=C1
Synonyms :
Loratidine; SCH 29851; Wyeth Brand of Loratadine
MDL No. :MFCD00672869
InChI Key :JCCNYMKQOSZNPW-UHFFFAOYSA-N
Pubchem ID :3957

Safety of Loratadine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Loratadine

GPCR

Isoform Comparison

Biological Activity

Target
  • H1 receptor

    B(0)AT2, IC50:4 μM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01506791 Healthy Phase 1 Completed - United States, Florida ... More >> SFBC Ft Myers Inc Broadway, Florida, United States, 33901 Less <<
NCT00816972 Post-nasal Drip ... More >> Seasonal Allergic Rhinitis Rhinorrhea Less << Phase 2 Completed - -
NCT00783211 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT02646020 Non-small Cell Lung Cancer Phase 2 Unknown December 2017 China, Guangdong ... More >> Cancer Center of Sun-Yat Sen University (CCSYSU) GuangZhou, Guangdong, China, 510060 Less <<
NCT00751166 Urticaria Phase 4 Terminated(Study could not be ... More >>re-supplied with study medication in a timely manner.) Less << - -
NCT00751218 Urticaria Phase 4 Completed - -
NCT00866788 - Completed - -
NCT00779116 Allergies Phase 4 Completed - -
NCT00794378 Allergic Rhinitis Phase 3 Completed - -
NCT00866788 Chronic Idiopathic Urticaria Phase 2 Completed - -
NCT00783146 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00794794 Allergic Rhinitis Phase 3 Completed - -
NCT00780403 - Completed - -
NCT00780403 Allergies Phase 4 Completed - -
NCT02424539 Rhinitis, Allergic, Perennial ... More >>and Seasonal Less << Phase 4 Completed - China, Fujian ... More >> GSK Investigational Site Xiamen, Fujian, China, 361003 China, Guangdong GSK Investigational Site Shenzhen, Guangdong, China, 518038 China, Hunan GSK Investigational Site Changsha, Hunan, China, 410005 GSK Investigational Site Changsha, Hunan, China, 410011 China, Jiangsu GSK Investigational Site Nanjing, Jiangsu, China, 210029 China, Shanxi GSK Investigational Site Taiyuan, Shanxi, China, 030016 China, Zhejiang GSK Investigational Site Wenzhou, Zhejiang, China, 323027 China GSK Investigational Site Beijing, China, 100034 GSK Investigational Site Beijing, China GSK Investigational Site Changsha, China GSK Investigational Site Chongqing, China, 400014 GSK Investigational Site Fuzhou, China, 350025 GSK Investigational Site Hangzhou, China, 310052 GSK Investigational Site Shanghai, China, 200040 GSK Investigational Site Shanghai, China, 200092 GSK Investigational Site Shanghai, China, 200127 Less <<
NCT00779116 - Completed - -
NCT00895531 Arthroplasty, Replacement, Kne... More >>e Less << Phase 4 Terminated(Investigator left i... More >>nstitution) Less << - United States, Kentucky ... More >> University of Louisville Hospital Louisville, Kentucky, United States, 40202 Less <<
NCT00895531 - Terminated(Investigator left i... More >>nstitution) Less << - -
NCT00405964 - Completed - -
NCT00406783 Rhinitis, Allergic, Seasonal ... More >> Rhinitis, Allergic, Perennial Less << Phase 3 Completed - -
NCT00536380 - Completed - -
NCT00598611 Chronic Urticaria Phase 3 Completed - Germany ... More >> Allergie-Centrum-Charite Berlin, Germany, 10117 Less <<
NCT00405964 Allergic Rhinitis Phase 3 Completed - -
NCT00761527 - Completed - -
NCT00536380 Chronic Idiopathic Urticaria Phase 4 Completed - -
NCT00761527 - Completed - -
NCT00779636 Allergic Airway Disease Phase 4 Completed - -
NCT00406783 - Completed - -
NCT01314352 Fed Phase 1 Completed - United States, Florida ... More >> SFBC, Ft. Myers, Inc., Ft. Myers, Florida, United States, 33901 Less <<
NCT01314339 Fasting Phase 1 Completed - United States, Florida ... More >> SFBC, Ft. Myers, Inc., Ft. Myers, Florida, United States, 33901 Less <<
NCT00795522 Urticaria Phase 4 Completed - -
NCT00867191 Seasonal Allergic Rhinitis Phase 4 Completed - -
NCT00783354 Urticaria Chr... More >>onic Idiopathic Urticaria Less << Phase 4 Completed - -
NCT00600847 Acquired Cold Urticaria Phase 4 Completed - Germany ... More >> Allergie-Centrum-Charité Berlin Berlin, Germany, 10117 Less <<
NCT01506050 Healthy Phase 1 Completed - United States, Florida ... More >> SFBC Ft Myers Inc Broadway, Florida, United States, 33901 Less <<
NCT01506037 Healthy Phase 1 Completed - United States, Florida ... More >> SFBC Ft Myers Inc Broadway, Florida, United States, 33901 Less <<
NCT01444196 Urticaria Phase 4 Completed - Germany ... More >> Department of Dermatology, Venerology and Allergology Berlin, Germany, 10117 Less <<
NCT02320396 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT01916980 Eczema Dermat... More >>itis Dermal Pruritus Less << Phase 3 Completed - -
NCT01916980 - Completed - -
NCT02771249 Healthy Volunteers Phase 1 Recruiting December 31, 2019 United States, Maryland ... More >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-411-1222 ext TTY8664111010    prpl@cc.nih.gov Less <<
NCT02478398 Rhinitis, Allergic, Seasonal Phase 3 Completed - -
NCT02320396 - Completed - -
NCT00884325 Atopic Dermatitis ... More >> Pruritus Less << Phase 4 Completed - United States, Kentucky ... More >> DermResearch, PLLC Louisville, Kentucky, United States, 40217 Less <<
NCT01700192 Rhinitis, Allergic, Perennial ... More >> Rhinitis, Allergic, Nonseasonal Less << Phase 3 Completed - -
NCT01700192 - Completed - -
NCT01390441 Rheumatoid Arthritis Phase 1 Terminated(The study was termi... More >>nated early by the Sponsor for business reasons.) Less << - -
NCT02007434 - Completed - -
NCT02007434 Moderate or Severe Submental F... More >>ullness Less << Phase 3 Completed - United States, Arizona ... More >> Investigational Site Tempe, Arizona, United States, 85283 Less <<
NCT02545361 Lymphoma Phase 1 Phase 2 Withdrawn(Program de-prioritiz... More >>ed) Less << April 2020 -
NCT02495077 Kidney Transplant Phase 2 Recruiting September 2020 United States, Alabama ... More >> University of Alabama Recruiting Birmingham, Alabama, United States, 35294 Contact: Elizabeth Harmon    205-996-9632    eharmon@uabmc.edu    Principal Investigator: Roslyn B. Mannon, MD          United States, California University of California, Los Angeles Recruiting Los Angeles, California, United States, 90024 Contact: Suphamai Bunnapradist    310-794-8516    bunnapradist@mednet.ucla.edu    Principal Investigator: Janette Gadzhyan, MD, MS          University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Emilio Fernandez    415-353-8380    Emilio.Fernandez@ucsf.edu    Principal Investigator: Flavio Vincenti, MD          United States, Connecticut Yale University Recruiting New Haven, Connecticut, United States, 06511 Contact: Ricarda Tomlin    203-785-2073    ricarda.tomlin@yale.edu    Principal Investigator: Richard Formica Jr., MD          United States, Georgia Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Elizabeth Ferry    404-712-1816    elizabeth.ferry@emoryhealthcare.org    Principal Investigator: Kenneth Newell, MD, PhD          United States, Maryland University of Maryland Recruiting Baltimore, Maryland, United States, 21201 Contact: Roberto Ramirez    410-328-0303    rramirez@som.umaryland.edu    Contact: Amanda Bartosic    (410) 328-0303    abartosic@som.umaryland.edu    Principal Investigator: Jonathan S. Bromberg, MD, PhD          Johns Hopkins University Not yet recruiting Baltimore, Maryland, United States, 21287 Contact: Mullaney Marlene    410-614-6702    mmulla13@jhmi.edu    Contact: Darin Ostrander    (410) 614-6702    dostran1@jhmi.edu    Principal Investigator: Daniel C. Brennan, MD          United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Jennifer Mawby    734-936-4811    jlmawby@med.umich.edu    Principal Investigator: Randall Sung, MD          United States, Missouri Washington University Recruiting Saint Louis, Missouri, United States, 63110 Contact: Cusanelli Rebecca    314-362-4109    rcusanel@dom.wustl.edu    Principal Investigator: Tarek Alhamad, MD          United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Douglas Wilson    212-659-8049    Douglas.Wilson@mountsinai.org    Principal Investigator: Madhav Menon, MD          Principal Investigator: Peter Heeger, MD          United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44106 Contact: Dianna Sendrey    216-444-0486    sendred2@ccf.org    Principal Investigator: Emilio Poggio, MD          University Hospitals of Cleveland Recruiting Cleveland, Ohio, United States, 44106 Contact: Tracey Lee    216-844-5396    tracey.lee@uhhospitals.org    Principal Investigator: Donald Hricik, MD          United States, Wisconsin University of Wisconsin Recruiting Madison, Wisconsin, United States, 53792 Contact: Alyssa Stucke    608-265-1257    stucke@surgery.wisc.edu    Principal Investigator: David Foley, MD          Canada, Manitoba University of Manitoba Recruiting Winnipeg, Manitoba, Canada, R3A 1R9 Contact: Caroline Slivinski    (204) 787-8662    cslivinski@exchange.hsc.mb.ca    Principal Investigator: Peter Nickerson, MD          Principal Investigator: David Rush, MD          Canada, Ontario Toronto General Hospital Recruiting Toronto, Ontario, Canada, M5G 2C4 Contact: Franz Marie Gumabay    (416) 340-4800 ext 6806    franzmarie.gumabay@uhn.ca    Principal Investigator: Kathryn Tinckam, MD Less <<
NCT00884325 - Completed - -
NCT00727727 - Completed - Germany ... More >> Medical Practice for Neurology Dresden, Germany, 01307 Medical Practice for Neurology Wedel, Germany, 22880 Less <<
NCT00725478 - Completed - -
NCT01507792 Cough Larynge... More >>al Disease Bronchial Disease Iron Deficiency Less << Not Applicable Completed - Italy ... More >> Respiratory Pathophysiology Clinic, ASO San Giovanni Battista Turin, Italy, 10126 Less <<
NCT02583594 Progressive Multiple Sclerosis Phase 1 Active, not recruiting April 2021 Spain ... More >> Investigational Site Number 724001 Barcelona, Spain, 08035 Less <<
NCT01390441 - Terminated(The study was termi... More >>nated early by the Sponsor for business reasons.) Less << - -
NCT00562159 - Completed - -
NCT00561717 Seasonal Allergic Rhinitis Phase 4 Completed - Canada, Ontario ... More >> Kingston, Ontario, Canada, K7L 2V7 Less <<
NCT00550550 Rhinoconjunctivitis ... More >> Rhinitis Conjunctivitis Allergy Less << Phase 3 Completed - -
NCT00721331 Atopic Dermatitis Phase 1 Completed - Germany ... More >> PROINNOVERA GmbH Muenster, Germany Less <<
NCT00757562 Chronic Idiopathic Urticaria ... More >> Atopy Less << Phase 3 Completed - -
NCT00481676 Chronic Urticaria Phase 2 Completed - Germany ... More >> Novartis Investigative Site Berlin, Germany Novartis Investigative Site Bonn, Germany Novartis Investigative Site Dresden, Germany Novartis Investigative Site Giessen, Germany Novartis Investigative Site Hamburg, Germany Novartis Investigative Site Hannover, Germany Novartis Investigative Site Koeln, Germany Novartis Investigative Site Leipzig, Germany Novartis Investigative Site Luebeck, Germany Novartis Investigative Site Mainz, Germany Novartis Investigative Site Munich, Germany Less <<
NCT00449072 Rhinitis, Allergic, Perennial Phase 4 Completed - United States, New Jersey ... More >> Sanofi-Aventis Administrative Office Bridgewater, New Jersey, United States, 08807 Less <<
NCT00562159 Rhinoconjunctivitis ... More >> Rhinitis Conjunctivitis Allergy Less << Phase 3 Completed - -
NCT01096615 Rhinitis Phase 3 Completed - -
NCT00449072 - Completed - -
NCT01154153 Rhinitis, Allergic, Perennial ... More >>and/or Seasonal Less << Phase 4 Completed - United States, California ... More >> Investigational Site Number 840003 Cypress, California, United States, 90630 United States, Georgia Investigational Site Number 840006 Stockbridge, Georgia, United States, 30281 United States, Massachusetts Investigational Site Number 840007 North Dartmouth, Massachusetts, United States, 02747 United States, Minnesota Investigational Site Number 840010 Plymouth, Minnesota, United States, 55441 United States, Nebraska Investigational Site Number 840001 Omaha, Nebraska, United States, 68144 United States, North Carolina Investigational Site Number 840008 Raleigh, North Carolina, United States, 27607 United States, South Carolina Investigational Site Number 840002 Spartanburg, South Carolina, United States, 29307 United States, Texas Investigational Site Number 840005 San Antonio, Texas, United States, 78229 Less <<
NCT01154153 - Completed - -
NCT00481676 - Completed - -
NCT01007864 Idiopathic Parkinson's Disease Phase 3 Completed - Germany ... More >> Ulm, Baden-Württemberg, Germany, 89081 Wolfach, Baden-Württemberg, Germany, 77709 München, Bayern, Germany, 80804 Berlin-Steglitz, Berlin, Germany, 12163 Marburg, Hessen, Germany, 35043 Göttingen, Niedersachsen, Germany, 37075 Dresden, Sachsen, Germany, 01307 Leipzig, Sachsen, Germany, 04107 Gera, Thüringen, Germany, 07551 Stadtroda, Thüringen, Germany, 07646 Berlin, Germany, 12200 Berlin, Germany, 13353 Less <<
NCT01413958 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT01519856 - Completed - Germany ... More >> Dr. Erich Scholz Boeblingen, Baden-Wuertemberg, Germany, 71034 Less <<
NCT00550550 - Completed - -
NCT01413958 - Completed - -
NCT00796211 Plaque Psoriasis Phase 2 Completed - Germany ... More >> ProInnovera Muenster, Germany Less <<
NCT03004131 Seasonal Allergic Rhinitis Phase 4 Completed - Canada, Ontario ... More >> Inflamax Research Mississauga, Ontario, Canada, L4W1Ae Less <<
NCT00979901 - Completed - -
NCT02517957 Eczema Phase 2 Unknown - -
NCT00972738 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00963469 - Completed - -
NCT00972738 - Completed - -
NCT00960141 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00960141 - Completed - -
NCT01330017 - Completed - -
NCT00963469 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00525382 Urticaria Phase 3 Completed - -
NCT00979901 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00525278 Rhinitis Alle... More >>rgic Seasonal Less << Phase 3 Completed - -
NCT00524836 Rhinitis Alle... More >>rgic Perennial Less << Phase 3 Completed - -
NCT00963599 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT00423995 Seasonal Allergic Rhinitis Phase 3 Completed - -
NCT02339714 Rhinitis, Allergic, Perennial Phase 2 Completed - China, Beijing ... More >> Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing, Beijing, China, 100053 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences Beijing, Beijing, China, 100700 Mentougou Hospital of TCM Beijing, Beijing, China, 102300 Less <<
NCT01330017 Rhinitis Seas... More >>onal Rhinitis Less << Phase 2 Completed - -
NCT00946608 Allergy Phase 1 Completed - -
NCT01055756 Allergic Rhinitis Phase 3 Withdrawn June 2010 Brazil ... More >> LAL Clínica Pesquisa e Desenvolvimento Ltda Valinhos, São Paulo, Brazil, 13276245 Less <<
NCT03443843 Rhinitis, Allergic Phase 4 Completed - Canada, Ontario ... More >> Kingston General Hospital Kingston, Ontario, Canada, K7L 2V7 Less <<
NCT00319995 Rhinitis, Allergic, Seasonal Phase 3 Completed - -
NCT01712009 Bone Pain in Stage I - III Bre... More >>ast Cancer Less << Phase 2 Completed - -
NCT01469234 - Completed - -
NCT01712009 - Completed - -
NCT00963599 - Completed - -
NCT01451996 Healthy PHASE4 COMPLETED 2025-12-12 University of Chicago, Chicago... More >>, Illinois, 60637, United States Less <<
NCT01673620 Allergic Rhinitis Phase 3 Completed - -
NCT01673620 - Completed - -
NCT01451996 Healthy PHASE4 COMPLETED 2025-12-12 University of Chicago, Chicago... More >>, Illinois, 60637, United States Less <<
NCT02653339 Rhinitis, Allergic, Perennial Not Applicable Unknown August 2018 China, Beijing ... More >> Peking Union Medical College Hospital traditional Chinese medicine department Not yet recruiting Beijing, Beijing, China, 100730 Contact: Xiaoyang Zhang, Doctor    (+86)13910769068    zhangxymz@163.com Less <<
NCT02392039 Lymphoma Early Phase 1 Terminated(Slow Accrual) - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT01469234 Rhinitis Phase 4 Completed - -
NCT00776217 Healthy Not Applicable Completed - -
NCT00762983 - Completed - -
NCT03517930 Clinical Pharmacology Phase 1 Completed - United States, New Jersey ... More >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Less <<
NCT01228630 Perennial Allergic Rhinitis Phase 3 Completed - Brazil ... More >> Lal Clínica Pesquisa E Desenvolvimento Ltda Valinhos, Sao Paulo, Brazil, 13270-245 Less <<
NCT00776282 Healthy Not Applicable Completed - -
NCT03517943 Clinical Pharmacology Phase 1 Completed - United States, New Jersey ... More >> Frontage Clinical Services Secaucus, New Jersey, United States, 07094 Less <<
NCT00837915 Healthy Not Applicable Completed - Canada, Quebec ... More >> MDS Pharma Services Montreal, Quebec, Canada, H4R2N6 Less <<
NCT03151720 Healthy Phase 1 Completed - Taiwan ... More >> Tri-Service Genaral Hospital Taipei, Taiwan, 11490 Less <<
NCT00845546 Healthy Not Applicable Completed - Canada, Quebec ... More >> MDS Pharma Services St. Laurent, Quebec, Canada, H4R 2N6 Less <<
NCT00730912 Perennial Allergic Rhinitis Phase 4 Completed - -
NCT02576808 Rhinitis,Allergic Phase 2 Completed - Thailand ... More >> Thammasat University Hospital Khlong Luang,, Pathumthani, Thailand, 12120 Less <<
NCT02932774 Allergic Rhinitis ... More >> Hay Fever SAR Rhinitis, Allergic, Seasonal Less << Phase 4 Completed - -
NCT02513290 Allergic Rhinitis Phase 4 Completed - -
NCT00963573 Rhinitis Phase 4 Completed - -
NCT03196531 Healthy Phase 1 Completed - China ... More >> Xiangya Hospital Central South University Changsha, China, 410008 Less <<
NCT03376594 Allergic Rhinitis Phase 2 Completed - Thailand ... More >> Faculty of Medicine Khlong Luang, Pathumthani, Thailand, 12120 Less <<
NCT02305979 Leukemia|Lymphoma COMPLETED 2025-09-17 Comprehensive Cancer Center of... More >> Wake Forest University, Winston-Salem, North Carolina, 27157, United States Less <<
NCT03372473 Asthma in Children Phase 3 Completed - -
NCT01311336 Pegfilgrastim-induced Back and... More >> Leg Pain Less << Phase 2 Unknown June 2013 United States, Maine ... More >> Cancer Care of Maine Recruiting Brewer, Maine, United States, 04412 Contact: Thomas H Openshaw, MD    207-973-7478    topenshaw@emh.org    Principal Investigator: Thomas H Openshaw, MD          Sub-Investigator: Andrew Hertler, MD          Maine Center for Cancer Medicine Recruiting Scarborough, Maine, United States, 04074 Contact: Matthew Dugan, DO    207-885-7600    duganm@mccm.org    Principal Investigator: Matthew Dugan, DO          Sub-Investigator: Tracey Weisberg, MD          Sub-Investigator: Christian Thomas, MD          York Hospital Recruiting York, Maine, United States, 03909 Contact: Jonathan Eneman, MD    207-351-3777    jeneman@yorkhospital.com    Principal Investigator: Jonathan Eneman, MD          United States, New York CR Wood Cancer Center Recruiting Glens Falls, New York, United States, 12801 Contact: Aqeel Gillani, MD    518-926-6700    aqeelgillani@hotmail.com    Principal Investigator: Aqeel Gillani, MD          United States, Vermont Mountainview Medical Center Recruiting Berlin, Vermont, United States, 05602 Contact: John Valentine, MD    802-225-5400    john.valentine@cvmc.org    Principal Investigator: John Valentine, MD          Sub-Investigator: David Ospina, MD          Vermont Cancer Center Recruiting Burlington, Vermont, United States, 05405 Contact: Steven M Grunberg, MD    802-656-5457    steven.grunberg@uvm.edu    Contact: Karen M Wilson, MEd    802-656-4101    karen.m.wilson@uvm.edu    Principal Investigator: Steven M Grunberg, MD          Sub-Investigator: Joanna Schwartz, PharmD          Vermont Center for Cancer Medicine Recruiting Colchester, Vermont, United States, 05446 Contact: Dennis Sanders, MD    802-655-3400    Dennis.Sanders@vtmednet.org    Sub-Investigator: Paul Unger, MD          Sub-Investigator: Dennis Sanders, MD          Sub-Investigator: Johannes Nunnink, MD Less <<
NCT00730912 - Completed - -
NCT02593747 Histamine H1 Antagonists, Non-... More >>Sedating Less << Phase 1 Completed - Germany ... More >> Neu-Ulm, Bayern, Germany, 89231 Less <<
NCT03640273 Allergic Rhinitis ... More >> Adverse Drug Event Quality of Life Less << Phase 2 Completed - Thailand ... More >> Thammasat University Khlong Luang, Pathumthani, Thailand, 12120 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.06mL

2.61mL

1.31mL

26.12mL

5.22mL

2.61mL

References

 

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