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Chemical Structure| 1454682-72-4 Chemical Structure| 1454682-72-4

Structure of LY3009120
CAS No.: 1454682-72-4

Chemical Structure| 1454682-72-4

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LY3009120 (DP-4978) is a pan RAF inhibitor that inhibits BRAFV600E, BRAFWT, and CRAFWT with IC50 values of 5.8 nM, 9.1 nM, and 15 nM, respectively.

Synonyms: DP-4978

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Product Details of LY3009120

CAS No. :1454682-72-4
Formula : C23H29FN6O
M.W : 424.51
SMILES Code : O=C(NC1=CC(C2=CC3=CN=C(NC)N=C3N=C2C)=C(C)C=C1F)NCCC(C)(C)C
Synonyms :
DP-4978
MDL No. :MFCD28411374
InChI Key :HHCBMISMPSAZBF-UHFFFAOYSA-N
Pubchem ID :71721540

Safety of LY3009120

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of LY3009120

MAPK

Isoform Comparison

Biological Activity

Target
  • B-Raf

    BRAF WT, IC50:15 nM

    BRAF(V600E), IC50:5.8 nM

  • C-Raf/Raf-1

    C-Raf, IC50:4.3 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL

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