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CAS No. :	1391426-24-6
Formula :	C₂₃H₂₆Cl₅N₅
M.W :	549.75
SMILES Code :	CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNC3=CC=NC4=CC(Cl)=CC=C34.[H]Cl.[H]Cl.[H]Cl
Synonyms :	Lys01 trihydrochloride; Lys01; Lys05 (hydrochloride)
MDL No. :	MFCD28963913
InChI Key :	JTUYDBHQGOZPQQ-UHFFFAOYSA-N
Pubchem ID :	70673566

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

MCF-7 cells	12.3 ± 0.7 µM	24 hours	Evaluate antiproliferative activity, results showed BAQ12 and BAQ13 had ~3-fold higher potency than Lys05	Nat Commun. 2020 Sep 15;11(1):4615
HEL cells	5 µM		Lys05 reduced HEL cell number independently of ruxolitinib inhibition.	Blood Cancer J. 2023 Jul 10;13(1):106
H460 cells	11.1 ± 0.6 µM	24 hours	Evaluate antiproliferative activity, results showed BAQ12 and BAQ13 had ~3-fold higher potency than Lys05	Nat Commun. 2020 Sep 15;11(1):4615
HT29 cells	10.6 ± 3.4 µM	24 hours	Evaluate antiproliferative activity, results showed BAQ12 and BAQ13 had ~3-fold higher potency than Lys05	Nat Commun. 2020 Sep 15;11(1):4615
BXPC-3 cells	7.8 ± 0.9 µM	24 hours	Evaluate antiproliferative activity, results showed BAQ12 and BAQ13 had ~3-fold higher potency than Lys05	Nat Commun. 2020 Sep 15;11(1):4615
PANC-1 cells	13.3 ± 2.0 µM	24 hours	Evaluate antiproliferative activity, results showed BAQ12 and BAQ13 had ~3-fold higher potency than Lys05	Nat Commun. 2020 Sep 15;11(1):4615
MIA PaCa-2 cells	16.7± 4.7 µM	24 hours	Evaluate antiproliferative activity, results showed BAQ12 and BAQ13 had ~3-fold higher potency than Lys05	Nat Commun. 2020 Sep 15;11(1):4615
A375P cells	0 – 1000 nM	2 weeks	To evaluate the effect of Lys05 on long-term clonogenic growth, results showed that Lys05 significantly suppressed long-term clonogenic growth of melanoma cells.	Cancer Discov. 2019 Feb;9(2):220-229
A375P cells	3 μM	6 hours	To evaluate the effect of Lys05 on lysosomal membrane permeabilization, results showed that Lys05 treatment increased lysosomal membrane permeabilization.	Cancer Discov. 2019 Feb;9(2):220-229
MDA-MB-231 cells	20 μM	72 hours	Evaluate Lys05's effect on pro-inflammatory cytokine expression; significantly increased Cxcl9, Cxcl10, Ccl5, Ifna, and Ifnb expression	Autophagy. 2024 Mar;20(3):525-540
Yumm 2.1 CTNNB1	1, 3, 5, 10μM	16-24 hours	To assess the sensitivity of Lys05 in β-catenin-stabilized melanoma cells	Cancer Res. 2017 Nov 1;77(21):5873-5885
Yumm 1.7 overexpressing WNT5A	1, 3, 5, 10μM	16-24 hours	To assess the sensitivity of Lys05 in Wnt5A-high and β-catenin-low melanoma cells	Cancer Res. 2017 Nov 1;77(21):5873-5885
Yumm 1.7	1, 3, 5, 10μM	16-24 hours	To assess the sensitivity of Lys05 in Wnt5A-low and β-catenin-high melanoma cells	Cancer Res. 2017 Nov 1;77(21):5873-5885
WM164	1, 3, 5, 10μM	16-24 hours	To assess the sensitivity of Lys05 in Wnt5A-low and β-catenin-high melanoma cells	Cancer Res. 2017 Nov 1;77(21):5873-5885
FS13	1, 3, 5, 10μM	16-24 hours	To assess the sensitivity of Lys05 in Wnt5A-high and low β-catenin melanoma cells	Cancer Res. 2017 Nov 1;77(21):5873-5885
HL-60 cells	5 µM		Lys05 modified neither the response of JAK2 WT HL-60 cells to ruxolitinib.	Blood Cancer J. 2023 Jul 10;13(1):106
SET-2 cells	5 µM		Lys05 strongly enhanced the cytotoxic effects of ruxolitinib in JAK2V617F cell lines.	Blood Cancer J. 2023 Jul 10;13(1):106
K562 cells expressing mRFP-GFP-LC3	10 µM	4 hours	To evaluate the inhibitory effect of Lys05 on autophagy flux, results showed that Lys05 treatment led to a significant accumulation of yellow fluorescence, indicating a complete block in autophagy flow.	Leukemia. 2019 Apr;33(4):981-994
K562 cells	1 µM and 10 µM	4 hours	To evaluate the inhibitory effect of Lys05 on autophagy, results showed that Lys05 at 1 µM and 10 µM concentrations significantly increased the level of membrane-bound LC3B-II, indicating increased accumulation of autophagosomes.	Leukemia. 2019 Apr;33(4):981-994
CD34+ CML cells	5 µM		To evaluate the inhibitory effect of Lys05 on autophagy, results showed that Lys05 treatment led to accumulation of LC3 puncta and increased levels of autophagy substrates SQSTM1/p62, NBR1, and NCOA4.	Leukemia. 2019 Apr;33(4):981-994

NSG mice	HT29 colorectal cancer xenograft model	Intraperitoneal injection	10 mg/kg	Two daily doses	To evaluate the effect of Lys05 on tumor growth, results showed that two doses of Lys05 had only a transient effect on tumor growth.	Cancer Discov. 2019 Feb;9(2):220-229
Mice	Melanoma xenograft models and colon cancer xenograft model	Intraperitoneal injection	10 mg/kg to 80 mg/kg	Daily dosing or intermittent high-dose administration	Lys05 significantly blocks autophagy in vivo and exhibits single-agent antitumor activity. Compared to HCQ, Lys05 more effectively accumulates in and deacidifies lysosomes, leading to sustained autophagy inhibition and tumor growth suppression. High-dose Lys05 causes Paneth cell dysfunction and intestinal toxicity in mice.	Autophagy. 2012 Sep;8(9):1383-4
FVB mice	Transplanted PyMT-driven mammary tumor model	Intraperitoneal injection	50 mg/kg	Once daily for one week	Assess Lys05's impact on CD8+ T cell infiltration; significantly increased CD8+ T cell infiltration in tumors	Autophagy. 2024 Mar;20(3):525-540
Mice	Yumm 1.7, Yumm 1.7 overexpressing WNT5A, Yumm 2.1 CTNNB1 melanoma model	Intraperitoneal injection	20mg/kg	Once daily for 14 days	To evaluate the inhibitory effect of Lys05 on melanoma tumor growth with different Wnt status	Cancer Res. 2017 Nov 1;77(21):5873-5885
NSG mice	HEL cell xenograft model	Intraperitoneal injection	32 mg/kg	Daily for 14 days	Lys05 improved the response to ruxolitinib and significantly prolonged the mice's overall survival.	Blood Cancer J. 2023 Jul 10;13(1):106
Nude mice	C8161 xenograft	Intraperitoneal injection	76 mg/kg	Once daily for 48 hours	Evaluate the in vivo autophagy inhibition and antitumor efficacy of Lys05. Results showed Lys05 significantly increased AV number and inhibited tumor growth.	Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8
Wistar rats	HCC model	Intra-arterial administration	40 mg/kg	Single dose	Combination therapy coupling autophagy inhibition and TAE in a rat model of HCC resulted in a 21% increase in tumor necrosis compared with TAE alone	Radiology. 2017 Jun;283(3):702-710
Mice	Scl-tTa-BCR-ABL/GFP-LC3 mouse model		20 mg/kg/day	2 days or 7 days	To evaluate the inhibitory effect of Lys05 on autophagy, results showed that Lys05 treatment led to increased GFP-LC3 levels and accumulation of SQSTM1/p62, indicating autophagy inhibition. Additionally, Lys05 treatment reduced the number of LT-HSCs and promoted expansion of MPP and LSK cells.	Leukemia. 2019 Apr;33(4):981-994

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CAS No.: 1391426-24-6

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CAS No.: 1391426-24-6

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed