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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
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Chemical Structure| 31576-51-9 Chemical Structure| 31576-51-9
Chemical Structure| 31576-51-9

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m-PEG2-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of m-PEG2-Amine

CAS No. :31576-51-9
Formula : C5H13NO2
M.W : 119.16
SMILES Code : COCCOCCN
MDL No. :MFCD09032941
InChI Key :QWCGXANSAOXRFE-UHFFFAOYSA-N
Pubchem ID :520530

Safety of m-PEG2-Amine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H301
Precautionary Statements:P210-P264-P270-P280-P301+P310+P330-P370+P378-P403+P235-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of m-PEG2-Amine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31576-51-9 ]

[ 31576-51-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 31576-51-9 ]
  • [ 42237-85-4 ]
  • 3-amino-5-bromo-N-(2-(2-methoxyethoxy)ethyl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
880 mg With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; at 20℃;Cooling with ice; (i) 3-Ami no-5-bromo-N-(2-(2-methoxyethoxy)ethyl)benzamideA stirred mixture of <strong>[42237-85-4]3-amino-5-bromobenzoic acid</strong> (800 mg, 3.59 mmol), 2-(2- methoxyethoxy)ethanamine (856 mg, 7.18 mmol) and Et3N (1.5 mL, 10.76 mmol) in DCM (13mL) was cooled in an ice bath. T3P (50 w/w in EtOAc, 3.2 mL, 5.38 mmol) was added dropwise, the ice bath was removed and the reaction mixture allowed to warm to room temperature. DMF (2 mL) was added to aid solubility and the reaction stirred at room temperature overnight. The reaction mixture was partitioned between sat. aq. NaHCO3 (50 mL) and DCM (50 mL). The aqueous phase was back extracted with fresh DCM (50 mL).The combined organic extracts were washed with water (100 mL), brine (100 mL), dried (MgSO4), filtered and concentrated in vacuo to afford an orange oil. The crude product was purified by chromatography on silica gel (40 g column, 0-5% MeOH) to afford the sub-title compound (880 mg) as an orange oil.1H NMR (DMSO-d6) 400 MHz, O: 8.36 (t, 1H), 7.07 (t, 1H), 7.00-6.99 (m, 1H), 6.84 (t, 1H),5.57 (s, 2H), 3.53-3.48 (m, 4H), 3.44-3.42 (m, 2H), 3.35 (q, 2H), 3.23 (s, 3H). LCMS m/z 317/319 (M÷H) (ES)
  • 2
  • [ 5926-51-2 ]
  • [ 31576-51-9 ]
  • 3-bromo-1-(2-(2-methoxyethoxy)ethyl)-1H-pyrrole-2,5-dione [ No CAS ]
 

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