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Chemical Structure| 883976-12-3 Chemical Structure| 883976-12-3

Structure of M8-B
CAS No.: 883976-12-3

Chemical Structure| 883976-12-3

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M8-B is an efficient TRPM8 antagonist that blocks TRPM8 channel activation induced by cold or TRPM8 agonists. M8-B can also lower deep body temperature (Tb) and is suitable for studying TRPM8-related pain and inflammation in the nervous system.

Synonyms: M8-B (hydrochloride)

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Product Details of M8-B

CAS No. :883976-12-3
Formula : C22H25ClN2O3S
M.W : 432.96
SMILES Code : O=C(C1=CC=CS1)N(CCN)CC2=CC=C(OCC3=CC=CC=C3)C(OC)=C2.[H]Cl
Synonyms :
M8-B (hydrochloride)
MDL No. :MFCD27978374
InChI Key :FMQJBHACRTZLME-UHFFFAOYSA-N
Pubchem ID :69316632

Safety of M8-B

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.55mL

2.31mL

1.15mL

23.10mL

4.62mL

2.31mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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