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Chemical Structure| 188343-77-3 Chemical Structure| 188343-77-3

Structure of MBP146-78
CAS No.: 188343-77-3

Chemical Structure| 188343-77-3

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MBP146-78 is an effective selective inhibitor of cGMP-dependent protein kinase, exhibiting cytotoxic activity against Toxoplasma gondii. It is applicable for research on related parasitic diseases.

Synonyms: MBP146-78

4.5 *For Research Use Only !

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Product Details of MBP146-78

CAS No. :188343-77-3
Formula : C21H22FN3
M.W : 335.42
SMILES Code : CN1CCC(C2=CC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2)CC1
Synonyms :
MBP146-78
MDL No. :MFCD30474871

Safety of MBP146-78

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Toxoplasma gondii RH-GCaMP6f 200 nM MBP146-78 is a specific inhibitor of PKG used to determine whether estrogen affects Ca2+ in parasites through PKG. Results showed that after MBP146-78 treatment, the Ca2+ spikes induced by estradiol and progesterone were reduced, indicating that PKG is an important factor in estrogen-induced Ca2+ signals. Front Microbiol. 2018 Jun 12;9:1266

Protocol

Bio Calculators
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1 mM

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10 mM

2.98mL

0.60mL

0.30mL

14.91mL

2.98mL

1.49mL

29.81mL

5.96mL

2.98mL

 

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