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Chemical Structure| 111797-22-9 Chemical Structure| 111797-22-9

Structure of MD2-IN-1
CAS No.: 111797-22-9

Chemical Structure| 111797-22-9

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MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).

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Product Details of MD2-IN-1

CAS No. :111797-22-9
Formula : C20H22O6
M.W : 358.39
SMILES Code : O=C(C1=CC=C(OC)C(OC)=C1)/C=C/C2=CC(OC)=C(OC)C(OC)=C2
MDL No. :MFCD01060969

Safety of MD2-IN-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of MD2-IN-1

pyroptosis
TLR

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Newborn Sprague-Dawley rats NEC rat model Gavage 20 mg/kg/d Once daily for 72 hours or until clinical symptoms of NEC appeared MI pretreatment reduced the occurrence and severity of NEC, inhibited NF-κB activation and release of inflammatory molecules (TNF-α and IL-6), and alleviated intestinal injury severity. PMC9663461

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.90mL

5.58mL

2.79mL

 

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