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Chemical Structure| 59-47-2 Chemical Structure| 59-47-2
Chemical Structure| 59-47-2

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Mephenesin is a centrally acting muscle relaxant which may work as an NMDA receptor antagonist.

Synonyms: Decontractyl; Cresoxydiol; Mephenesin, Prolaxin, Cresoxypropanediol, NSC 25234

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Product Citations

Product Citations

Wang, Jinli ; Bonacquisti, Emily E. ; Brown, Adam D. ; Nguyen, Juliane ;

Abstract: A limitation of using exosomes to their fullest potential is their limited secretion from cells, a major bottleneck to efficient exosome production and application. This is especially true for mesenchymal stem cells (MSCs), which can self-renew but have a limited expansion capacity, undergoing senescence after only a few passages, with exosomes derived from senescent stem cells showing impaired regenerative capacity compared to young cells. Here, we examined the effects of small mol. modulators capable of enhancing exosome secretion from MSCs. The treatment of MSCs with a combination of N-methyldopamine and norepinephrine robustly increased exosome production by three-fold without altering the ability of the MSC exosomes to induce angiogenesis, polarizemacrophages to an anti-inflammatory phenotype, or downregulate collagen expression. These small mol. modulators provide a promising means to increase exosome production by MSCs.

Keywords: exosome secretion ; proteomics ; small molecules

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Product Details of Mephenesin

CAS No. :59-47-2
Formula : C10H14O3
M.W : 182.22
SMILES Code : OCC(O)COC1=CC=CC=C1C
Synonyms :
Decontractyl; Cresoxydiol; Mephenesin, Prolaxin, Cresoxypropanediol, NSC 25234
MDL No. :MFCD00004718
InChI Key :JWDYCNIAQWPBHD-UHFFFAOYSA-N
Pubchem ID :4059

Safety of Mephenesin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312+P330-P501

Application In Synthesis of Mephenesin

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59-47-2 ]

[ 59-47-2 ] Synthesis Path-Downstream   1~1

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  • [ 60827-45-4 ]
  • [ 95-48-7 ]
  • [ 59-47-2 ]
 

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