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Chemical Structure| 60-56-0 Chemical Structure| 60-56-0

Structure of Methimazole
CAS No.: 60-56-0

Chemical Structure| 60-56-0

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Methimazole is an antithyroid medicine.

Synonyms: Thiamazole; NSC 38608; Northyx

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Product Citations

Product Citations

Frackowiak-Wojtasek, Bozena ; Gasowska-Bajger, Beata ; Tarasek, Damian ; Mytnik, Martyna ; Wojtasek, Hubert ;

Abstract: Lactoperoxidase was previously used as a model enzyme to test the inhibitory activity of selenium analogs of anti-thyroid drugs with 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) as a substrate. Peroxidases oxidize ABTS to a metastable radical ABTS.+, which is readily reduced by many antioxidants, including thiol-containing compounds, and it has been used for decades to measure antioxidant activity in biol. samples. We showed that anti-thyroid drugs 6-n-propyl-2-thiouracil, methimazole, and selenium analogs of methimazole also reduced it rapidly. This reaction may explain the anti-thyroid action of many other compounds, particularly natural antioxidants, which may reduce the oxidized form of iodine and/or tyrosyl radicals generated by thyroid peroxidase thus decreasing the production of thyroid hormones. However, influence of selenium analogs of methimazole on the rate of hydrogen peroxide consumption during oxidation of ABTS by lactoperoxidase was moderate. Direct hydrogen peroxide reduction, proposed before as their mechanism of action, cannot therefore account for the observed inhibitory effects. 1-Methylimidazole-2-selone and its diselenide were oxidized by ABTS.+ to relatively stable seleninic acid, which decomposed slowly to selenite and 1-methylimidazole. In contrast, oxidation of 1,3-dimethylimidazole-2-selone gave selenite and 1,3-dimethylimidazolium cation. Accumulation of the corresponding seleninic acid was not observed

Keywords: Methimazole ; n -Propyl-2-thiouracil ; Lactoperoxidase ; Horseradish peroxidase ; Selenium ; ABTS

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Product Details of Methimazole

CAS No. :60-56-0
Formula : C4H6N2S
M.W : 114.17
SMILES Code : S=C1NC=CN1C
Synonyms :
Thiamazole; NSC 38608; Northyx
MDL No. :MFCD00179321
InChI Key :PMRYVIKBURPHAH-UHFFFAOYSA-N
Pubchem ID :1349907

Safety of Methimazole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H303-H317-H361
Precautionary Statements:P201-P202-P261-P272-P280-P302+P352+P333+P313+P363-P308+P313-P405-P501

Isoform Comparison

Biological Activity

Description
Methimazole is a well-known antithyroid agent utilized primarily for the treatment and study of hyperthyroidism. Alongside its therapeutic use, methimazole is recognized for its significant hepatotoxicity, which is a major concern during its clinical application[1].[2].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00677469 Graves Disease Not Applicable Completed - Iran, Islamic Republic of ... More >> Endocrine and Metabolism Research Center Shiraz, Fars, Iran, Islamic Republic of Less <<
NCT01977963 - Recruiting - Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan Contact: Shyang-Rong Shih, PhD    886-972653337    srshih@ntu.edu.tw    Principal Investigator: Shyang-Rong Shih, PhD Less <<
NCT00725946 Breast Cancer ... More >> Breast Cancer Early Stage Breast Cancer (Stage 1-3) Breast Cancer Metastatic Breast Cancer Less << Early Phase 1 Terminated - United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less <<
NCT03303053 Hyperthyroidism ... More >> Graves Disease Less << Phase 3 Recruiting March 1, 2018 Malaysia ... More >> Hospital Queen Elizabeth 2 Recruiting Kota Kinabalu, Sabah, Malaysia, 88300 Contact: Yin Khet Fung, Dr.    +6 088324600    fung@doctors.org.uk    Contact: Gayathri D Krishnan, Dr.    +6 088324600    kgaya3@yahoo.com    Sub-Investigator: Pei Lin Chan, Dr.          Hospital Ampang Recruiting Ampang, Selangor, Malaysia, 68000 Contact: Vijiya M Valayatham, Dr    +60342896000    ammu_vj@yahoo.com    Hospital Putrajaya Recruiting Putrajaya, Wilayah Persekutuan, Malaysia, 62250 Contact: Serena SK Khoo, Dr.    +6 03 83124200    sk_liv@rocketmail.com    Contact: Zanariah Hussein, Dr.    +6 03 83124200    zanariahh@hotmail.com    Sub-Investigator: Siti A Alias, Dr          Sub-Investigator: Lisa Mohamed Nor, Dr          Sub-Investigator: Rashidah Bahari, Dr          Sub-Investigator: Nurul Z Badarudin, Dr Less <<
NCT01458600 Graves′ Disease Phase 4 Completed - Sweden ... More >> Departmenty of Endocrinology, Skane University Hospital Malmö, Sweden Department of Endocrinology, Karolinska Hospital Stockholm, Sweden Department of Internal Medicine, section of Endocrinology, Sodersjukhuset Stockholm, Sweden Less <<
NCT02812888 - Unknown June 2017 China, Jiangsu ... More >> The First People's Hospital of Xuzhou, Recruiting Xuzhou, Jiangsu, China, 221000 Contact: Zhen Zhongli, MD    +86 13952200973    1973324055@qq.com    Contact: Xi Jijiang, MD    +86 13814429263    549932860@qq.com Less <<
NCT03447093 - Recruiting December 2021 China, Heilongjiang ... More >> First affiliated hospital of Harbin medical university Recruiting Harbin, Heilongjiang, China, 150001 Contact: Yunwei Wei    +86-0451-85553099    hydwyw11@hotmail.com Less <<
NCT01534169 Graves' Disease Phase 1 Completed - China, Jiangsu ... More >> Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing, Jiangsu, China, 210006 Less <<
NCT02376088 Graves Disease COMPLETED 2025-06-14 -
NCT01247077 QoL Before and After 9 Month o... More >>f Medical Treatment of Graves′Thyrotoxicosis Potential Effect of Selenium Less << Phase 2 Completed - Sweden ... More >> Jan Calissendorff, Medical clinic, Eskilstuna, Sweden Eskilstuna, Södermanland, Sweden, 63188 Emil Mikulski Eskilstuna, Sweden, 63188 Less <<
NCT00150111 Graves′ Disease ... More >> Thyroid Associated Ophthalmopathy Less << Phase 1 Phase 2 Completed - Denmark ... More >> Department of Endocrinology, Odense University Hospital Odense, Funen, Denmark, 5000 Department of Hematology, Odense University Hospital Odense, Denmark, 5000 Less <<
NCT00150137 Toxic Nodular Goitre|Graves Di... More >>sease Less << PHASE4 COMPLETED 2025-12-04 Department of Endocrinology, O... More >>dense University Hospital, Odense, Funen, 5000, Denmark Less <<
NCT01893450 Graves Ophthalmopathy Not Applicable Terminated(Efficacy demonstrat... More >>ed on a preliminary analysis) Less << - Mexico ... More >> Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City, Distrito Federal, Mexico, 14000 Less <<
NCT00150124 Toxic Nodular Goitre ... More >> Graves' Disease Less << Phase 4 Completed - Denmark ... More >> Department of Endocrinology, Odense University Hospital Odense, Funen, Denmark, 5000 Less <<
NCT02654041 Glioblastoma Multiforme (GBM) Phase 2 Terminated(Drug manufacturer n... More >>o longer could supply for study) Less << - Israel ... More >> Tel-Aviv Medical Center, Israel Tel-Aviv, Israel, 64239 Less <<
NCT00917241 Graves' Disease Phase 4 Completed - -
NCT00001421 Dermatomyositis ... More >> Polymyositis Less << Phase 2 Completed - United States, Maryland ... More >> National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Bethesda, Maryland, United States, 20892 Less <<
NCT01560299 Graves Disease Not Applicable Completed - Iran, Islamic Republic of ... More >> Mashad University of Medical Sciences Mashad, Khorasan Razavi, Iran, Islamic Republic of, 91766 Less <<
NCT03433352 - Recruiting December 20, 2019 China, Heilongjiang ... More >> First affiliated hospital of Harbin medical university Recruiting Harbin, Heilongjiang, China, 150001 Contact: Yunwei Wei    +86-0451-85553099    hydwyw11@hotmail.com Less <<
NCT01849861 Healthy PHASE4 UNKNOWN 2025-09-14 Universidade Federal do Rio de... More >> Janeiro, Rio de Janeiro, 21941-590, Brazil Less <<
NCT02727738 Graves' Disease Not Applicable Completed - Italy ... More >> Endocrinology Unit Pisa, PI, Italy, 56124 Less <<
NCT03390582 - Recruiting November 1, 2021 China, Heilongjiang ... More >> First affiliated hospital of Harbin medical university Recruiting Harbin, Heilongjiang, China, 150001 Contact: Yunwei Wei    +86-0451-85553099    hydwyw11@hotmail.com Less <<
NCT05461820 Graves Disease|Relapse|Treatme... More >>nt|Drug Withdrawal Less << PHASE4 RECRUITING 2030-07-31 the First Affiliated Hospital ... More >>of Nanjing Medical University, Nanjing, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.76mL

1.75mL

0.88mL

43.79mL

8.76mL

4.38mL

87.59mL

17.52mL

8.76mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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