Structure of Metyrapone
CAS No.: 54-36-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
Synonyms: Su-4885; NSC 25265; Metyrapone, Metopirone, SU 4885, Methbipyranone, Methopyrapone
4.5
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CAS No. : | 54-36-4 |
Formula : | C14H14N2O |
M.W : | 226.27 |
SMILES Code : | CC(C1=CC=CN=C1)(C)C(C2=CC=CN=C2)=O |
Synonyms : |
Su-4885; NSC 25265; Metyrapone, Metopirone, SU 4885, Methbipyranone, Methopyrapone
|
MDL No. : | MFCD00006397 |
InChI Key : | FJLBFSROUSIWMA-UHFFFAOYSA-N |
Pubchem ID : | 4174 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00004334 | - | Unknown | - | United States, Michigan ... More >> University of Michigan Health Systems Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Monica N. Starkman 313-764-6168 Less << | |
NCT00310427 | Alcohol Dependence ... More >> Alcoholism Less << | Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00310427 | - | Completed | - | - | |
NCT00006270 | - | Unknown | - | United States, Texas ... More >> Transitional Learning Community Galveston, Texas, United States, 77550 University of Texas Medical Branch Galveston, Texas, United States, 77555-0209 Less << | |
NCT03404817 | Cocaine Use Disorder | Phase 1 | Completed | - | United States, California ... More >> Collaborative Neuroscience Network, LLC Long Beach, California, United States, 90806 Less << |
NCT00426608 | Depressive Disorder and Anxiet... More >>y Disorders Less << | Phase 1 | Completed | - | United Kingdom ... More >> GSK Investigational Site Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Less << |
NCT02856854 | Cocaine Use Disorder | Phase 1 | Completed | - | United States, Kansas ... More >> Vince & Associates Overland Park, Kansas, United States, 66212 Less << |
NCT00033098 | Cocaine-Related Disorders|Infu... More >>sions, Intravenous Less << | PHASE1 | UNKNOWN | 2025-05-02 | Cincinnati VA Medical Center, ... More >>Cincinnati, Ohio, 45220, United States Less << |
NCT01620684 | Metabolic Syndrome ... More >> Obesity Insulin Resistance Less << | Phase 4 | Unknown | - | Australia, Victoria ... More >> Heart Centre, Alfred Hospital Recruiting Prahran, Melbourne, Victoria, Australia, 3181 Contact: Nora E Straznicky, BPharm PhD MPH 61 3 8532 1371 nora.straznicky@bakeridi.edu.au Principal Investigator: Nora E Straznicky, PhD MPH Less << |
NCT00567814 | Cocaine Dependence ... More >> Cocaine Addiction Less << | Not Applicable | Completed | - | United States, Louisiana ... More >> Department of Psychiatry, Psychopharmacology Research Clinic Shreveport, Louisiana, United States, 71103 Less << |
NCT02368379 | Prader Willi Syndrome ... More >> Adrenal Insufficiency Less << | Not Applicable | Completed | - | United States, Ohio ... More >> Nationwide Children's Hospital Columbus, Ohio, United States, 43205 Less << |
NCT01375920 | Depression | Phase 3 | Completed | - | United Kingdom ... More >> Stockton Affective Disorders Service Newcastle upon Tyne, Teesside, United Kingdom, TS17 6SD Newcastle Community Mental Health Team Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP Regional Affective Disorders Service Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP North Tyneside Community Mental Health Team Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE28 7PD Newcastle Magnetic Resonance Centre Newcastle Upon Tyne, Tyne and Wear, United Kingdom, NE4 5PL Bradford District Care Trust Bradford, United Kingdom Leeds Community Mental Health Team Leeds, United Kingdom, LS12 3QE Affective Disorders Service Manchester, United Kingdom, M13 9PT Manchester Community Mental Health Team Manchester, United Kingdom, M30 0GT Manchester Magnetic Resonance Centre Manchester, United Kingdom Northumberland, Tyne and Wear NHS Foundation Trust Newcastle upon Tyne, United Kingdom, NE3 3XT Less << |
NCT00125554 | Major Depressive Disorder | PHASE2 | COMPLETED | 2025-07-01 | Dept. of Psychiatry and Psycho... More >>therapy, UKE, Hamburg, 20246, Germany Less << |
NCT01673087 | Stress | Phase 1 | Completed | - | United States, Michigan ... More >> University of Michigan Health System Ann Arbor, Michigan, United States, 48109 Less << |
NCT02297945 | Cushing's Syndrome | Phase 3 | Recruiting | November 2018 | Belgium ... More >> University hospital Antwerp Not yet recruiting Antwerp, Belgium CHU Erasme Recruiting Brussels, Belgium Contact: Driessens, Dr +32 2 5553131 University hospital Saint Luc Recruiting Brussels, Belgium Contact: Maiter, Prof +32 2 764 11 11 CHU Liège Recruiting Liege, Belgium Contact: Beckers, Prof +32 4 242 52 00 Germany Charité Berlin Not yet recruiting Berlin, Germany, 10117 Contact: Tina Kienitz, Dr +49 30 45050 Universitätsklinikum Essen Recruiting Essen, Germany Contact: Führer-Sakel, Prof +49 201 7230 Munich university Recruiting Munich, Germany Contact: Beuschlein, Prof +49 89 440052100 University hospital Wuerzburg Recruiting Wuerzburg, Germany Contact: Fassnacht, Prof +49 931 2010 Hungary State health center Not yet recruiting Budapest, Hungary, 10062 Contact: Laszlo Kovacs, Dr Contact 06 465-1800 3. Semmelweis Egyetem II. Belgyógyászati Klinika Recruiting Budapest, Hungary Contact: Toth, Dr +36 1 266 0926 University Debrecen Not yet recruiting Debrecen, Hungary Contact: Endre Nagy, Dr University of Pecs Recruiting Pecs, Hungary Contact: Mezosi, Dr +36 72 501 599 University of Szeged Not yet recruiting Szeged, Hungary Contact: Zsuzsanna Valkusz, Prof Italy San Luigi Gonzaga Hospital, University of Turin Recruiting Orbassano, Turin, Italy, 10043 Contact: Massimo Terzolo, Prof +39 011 90261 Grande Ospedale Metropolitano Niguarda Recruiting Milan, Italy Contact: Loli, Dr +39 02 6444.1 Ospedale San Luca IRCCS Istituto Auxologico Italiano Recruiting Milan, Italy Contact: Cavagnini, Prof +39 02 619111 S. Giuseppe Hospital Recruiting Milan, Italy Contact: Arosio, Dr +39 0575 37341 Federico II University Recruiting Naples, Italy Contact: Pivonello, Prof +39 081 253 1111 University of Padova Recruiting Padova, Italy Contact: Boscaro, Prof +39 049 827 5111 University of Turin Recruiting Turin, Italy Contact: Ghigo, Dr +39 011 670 6111 Poland Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Not yet recruiting Gliwice, Poland Contact: Barbara Jarzab, Prof University Hospital Recruiting Krakow, Poland Contact: Motyka, Dr +48 12 424 70 00 University Clinical Hospital Not yet recruiting Wrocław, Poland Contact: Marek Bolanowski, Prof +48 71 327 09 00 Spain University hospital clinic of Barcelona Recruiting Barcelona, Spain Contact: Hanzu, Dr +34 932 27 54 00 Hospital Universitario La Ribera Recruiting Valencia, Spain Contact: Fajardo, Dr +34 962 45 81 00 Turkey Ankara Numune Training and Research Hospital Not yet recruiting Ankara, Turkey Contact: Dilek Berker, Prof Dokuz Eylul UMF Not yet recruiting Izmir, Turkey Contact: Baris Akinci, Prof Ondokuz Mayıs University Medical Faculty Not yet recruiting Samsun, Turkey Contact: Aysegül Atmaca, Prof Karadeniz Teknik University Not yet recruiting Trabzon, Turkey Contact: Mustafa Koçak, Prof Less << |
NCT02406066 | Cocaine Use Disorder ... More >> Tobacco Use Disorder Less << | Phase 1 | Completed | - | United States, California ... More >> Collaborative Neuroscience Network, LLC Long Beach, California, United States, 90806 United States, Louisiana Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 Less << |
NCT03491696 | Depressive Disorder|Hormone Di... More >>sturbance Less << | PHASE4 | UNKNOWN | 2025-09-22 | Hopitaux Universitares de Stra... More >>sbourg, Strasbourg, Bas Rhin, 67000, France|Centre Hospitalier de Rouffach, Rouffach, Haut Rhin, 68250, France Less << |
NCT06106295 | Autonomous Cortisol Secretion|... More >>Mild Autonomous Cortisol Secretion (MACS) Less << | PHASE2 | RECRUITING | 2025-01-28 | Mayo Clinic Minnesota, Rochest... More >>er, Minnesota, 55905, United States Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.42mL 0.88mL 0.44mL |
22.10mL 4.42mL 2.21mL |
44.19mL 8.84mL 4.42mL |
Tags: Metyrapone | Su-4885 | P450 | Metabolic Enzyme | Tumor Metabolism | 54-36-4
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P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
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P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
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P350 | Gently wash with plenty of soap and water. |
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P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
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P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
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P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
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Storage | |
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H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
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H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
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H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
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H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
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H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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